CAS 100-33-4

pentamidine

Description:

Pentamidine is a chemical compound primarily known for its use as an antiprotozoal and antimicrobial agent. It is classified as a diamidine, characterized by the presence of two amidine functional groups. Pentamidine is typically encountered as a white to off-white crystalline powder that is soluble in water and various organic solvents. Its molecular formula is C19H24N4O2, and it has a relatively high molecular weight. The compound exhibits a range of biological activities, particularly against certain protozoan infections, such as those caused by Trypanosoma brucei, the causative agent of sleeping sickness, and Pneumocystis jirovecii, which can lead to pneumonia in immunocompromised individuals. Pentamidine's mechanism of action involves interference with nucleic acid metabolism and mitochondrial function in target organisms. While effective, it can also have side effects, including nephrotoxicity and hypotension, necessitating careful monitoring during treatment. Due to its pharmacological properties, pentamidine is administered via injection or inhalation, depending on the specific clinical indication.

Formula: C₁₉H₂₄N₄O₂

InChI: InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23)

InChI key: InChIKey=XDRYMKDFEDOLFX-UHFFFAOYSA-N

SMILES: C(=N)(N)C1=CC=C(OCCCCCOC2=CC=C(C(=N)N)C=C2)C=C1

Synonyms:

• 2-Hydroxyethanesulfonic Acid - 4,4'-[Pentane-1,5-Diylbis(Oxy)]Dibenzenecarboximidamide (2:1)
• 4,4'-(Pentamethylenedioxy)dibenzamidine
• 4,4'-Diamidino-α,ω-diphenoxypentane
• 4,4'-[Pentane-1,5-Diylbis(Oxy)]Dibenzenecarboximidamide
• 4,4-Pentamethylenedioxydibenzamidine
• 4,4′-[1,5-Pentanediylbis(oxy)]bis[benzenecarboximidamide]
• Benzamidine, 4,4'-(pentamethylenedioxy)di-
• Benzenecarboximidamide, 4,4'-[1,5-pentanediylbis(oxy)]bis-
• Mp 601205
• Nsc 9921
• Pentamidin
• Pentamidina
• p,p'-(Pentamethylenedioxy)dibenzamidine
• 4,4’-(pentamethylenedioxy)di-benzamidin
• 4,4'-(Pentane-1,5-diylbisoxy)bisbenzamidine
• 4-[5-(4-carbamimidoylphenoxy)pentoxy]benzenecarboximidamide
• 4,4'-[Pentamethylenebis(oxy)]bis(benzamidine)
• 4,4’-diamidino-alpha,omega-diphenoxypentane
• 4-[5-(4-amidinophenoxy)pentoxy]benzamidine
• 4,4'-[1,5-Pentanediylbis(oxy)]bisbenzamidine
• p,p’-(pentamethylene-dioxy)bis-benzamidine
• PENTAMIDINE
• 3-(1,3-Benzothiazol-2-yl)-7-diethylaminochromen-2-one
• 4,4'-(Pentane-1,5-diyldioxy)bis(benzenecarboxamidine)
• 4,4'-(Pentane-1,5-diylbis(oxy))dibenziMidaMide
• 4,4’-(1,5-pentanediylbis(oxy))bis-benzenecarboximidamid
• 4,4’-diamidinodiphenoxypentane

4-{[5-(4-carbamimidoylphenoxy)pentyl]oxy}benzene-1-carboximidamide

CAS: 100-33-4

Formula: C₁₉H₂₄N₄O₂

Purity: 99%

Color and Shape: Solid

Molecular weight: 340.4195

Ref: IN-DA00006J

Pentamidine

CAS: 100-33-4

Pentamidine

Purity: ≥98%

Molecular weight: 340.42g/mol

Ref: 54-BUP17579

4,4'-(Pentane-1,5-Diylbis(Oxy))Dibenzimidamide

CAS: 100-33-4

4,4'-(Pentane-1,5-Diylbis(Oxy))Dibenzimidamide

Purity: 98%

Molecular weight: 340.42g/mol

Ref: 54-OR1027884

Pentamidine

CAS: 100-33-4

Formula: C₁₉H₂₄N₄O₂

Molecular weight: 340.43

Ref: 4Z-P-155007

Pentamidine

CAS: 100-33-4

Pentamidine is an antifungal and antiprotozoal agent, interacting directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor

Formula: C₁₉H₂₄N₄O₂

Purity: 98.64% - 99.67%

Color and Shape: Crystallizes As Colorless Plates From Water Solid

Molecular weight: 340.42

Ref: TM-T23133

Pentamidine

CAS: 100-33-4

Pentamidine is a nonsteroidal anti-inflammatory drug that inhibits the polymerase chain reaction. Pentamidine has been shown to inhibit the growth of Leishmania, a protozoan parasite that causes leishmaniasis. It binds to DNA and alters its structure, which prevents transcription and replication. This drug also has a low toxicity and side effect profile, making it an attractive candidate for development as an anti-leishmanial agent.

Formula: C₁₉H₂₄N₄O₂

Purity: Min. 95 Area-%

Color and Shape: White Powder

Molecular weight: 340.42 g/mol

Ref: 3D-FP26808

4,4′-(Pentane-1,5-diylbis(oxy))dibenzimidamide

CAS: 100-33-4

Formula: C₁₉H₂₄N₄O₂

Purity: 99%

Color and Shape: Solid

Molecular weight: 340.427

Ref: 10-F092067

Pentamidine-d10

Controlled Product

CAS: 100-33-4

Formula: C₁₉D₁₀H₁₄N₄O₂

Color and Shape: Neat

Molecular weight: 350.481

Ref: TR-P272502