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CAS 100-33-4

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pentamidine

Description:
Pentamidine is a chemical compound primarily known for its use as an antiprotozoal and antimicrobial agent. It is classified as a diamidine, characterized by the presence of two amidine functional groups. Pentamidine is typically encountered as a white to off-white crystalline powder that is soluble in water and various organic solvents. Its molecular formula is C19H24N4O2, and it has a relatively high molecular weight. The compound exhibits a range of biological activities, particularly against certain protozoan infections, such as those caused by Trypanosoma brucei, the causative agent of sleeping sickness, and Pneumocystis jirovecii, which can lead to pneumonia in immunocompromised individuals. Pentamidine's mechanism of action involves interference with nucleic acid metabolism and mitochondrial function in target organisms. While effective, it can also have side effects, including nephrotoxicity and hypotension, necessitating careful monitoring during treatment. Due to its pharmacological properties, pentamidine is administered via injection or inhalation, depending on the specific clinical indication.
Formula:C19H24N4O2
InChI:InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23)
InChI key:InChIKey=XDRYMKDFEDOLFX-UHFFFAOYSA-N
SMILES:C(=N)(N)C1=CC=C(OCCCCCOC2=CC=C(C(=N)N)C=C2)C=C1
Synonyms:
  • 2-Hydroxyethanesulfonic Acid - 4,4'-[Pentane-1,5-Diylbis(Oxy)]Dibenzenecarboximidamide (2:1)
  • 4,4'-(Pentamethylenedioxy)dibenzamidine
  • 4,4'-Diamidino-α,ω-diphenoxypentane
  • 4,4'-[Pentane-1,5-Diylbis(Oxy)]Dibenzenecarboximidamide
  • 4,4-Pentamethylenedioxydibenzamidine
  • 4,4′-[1,5-Pentanediylbis(oxy)]bis[benzenecarboximidamide]
  • Benzamidine, 4,4'-(pentamethylenedioxy)di-
  • Benzenecarboximidamide, 4,4'-[1,5-pentanediylbis(oxy)]bis-
  • Mp 601205
  • Nsc 9921
  • See more synonyms
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