CAS 100040-31-1

gastric inhibitory polypeptide human

Description:

Gastric inhibitory polypeptide (GIP), also known as glucose-dependent insulinotropic polypeptide, is a peptide hormone produced in the K cells of the duodenum and jejunum in the gastrointestinal tract. It plays a crucial role in glucose metabolism by stimulating insulin secretion from the pancreas in response to food intake, particularly in the presence of glucose and fatty acids. GIP also inhibits gastric acid secretion and gastric motility, hence its name. The substance is composed of 42 amino acids and is part of the incretin family, which are hormones that enhance insulin release. GIP's action is mediated through specific receptors on pancreatic beta cells, and it has implications in metabolic disorders such as type 2 diabetes. The CAS number 100040-31-1 uniquely identifies this peptide, facilitating its study and application in research and clinical settings. Overall, GIP is significant in understanding the interplay between the digestive system and metabolic regulation.

Formula: C₂₂₆H₃₃₈N₆₀O₆₆S

Synonyms:

• H-Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln-OH
• Gip (Human)

Gastric Inhibitory Polypeptide (human)

CAS: 100040-31-1

Gastric inhibitory polypeptide (GIP), an incretin, represents an essential regulator of insulin secretion and glucose homeostasis.

Formula: C₂₂₆H₃₃₈N₆₀O₆₆S

Purity: 97.4%

Color and Shape: Whitish Powder

Molecular weight: 4983.6

Ref: 01-4030658

gastric inhibitory polypeptide (human)-Asn-Ile-Thr-Gln-OH

CAS: 100040-31-1

Formula: C₂₂₆H₃₃₈N₆₀O₆₆S

Purity: 95%

Color and Shape: Solid

Molecular weight: 4983.5293

Ref: IN-DA01EB06

GIP, human

CAS: 100040-31-1

Insulinotropic hormone from K-cells, binds GIP receptors, boosts insulin, affects lipids, and has antiapoptotic properties.

Formula: C₂₂₆H₃₃₈N₆₀O₆₆S

Purity: 98%

Color and Shape: Solid

Molecular weight: 4983.6

Ref: TM-TP2018

GIP (Human)

CAS: 100040-31-1

GIP is a peptide that is produced by the cells of the small intestine. GIP has been shown to be an inhibitor of insulin secretion and, in turn, may help regulate glucose levels. It also regulates growth hormone release in response to food intake. GIP acts as a ligand for the receptor known as the “gastric inhibitory polypeptide receptor” which is found on pancreatic beta cells and duodenal L-cells. This protein has been shown to activate ion channels and regulate their activity. The GIP receptor is also expressed on certain types of cancer cells, including breast cancer and colorectal cancer. Antibodies have been generated against this protein for use in research tools such as Western blotting or immunohistochemistry.

Formula: C₂₂₆H₃₃₈N₆₀O₆₆S

Purity: Min. 95%

Molecular weight: 4,983.5 g/mol

Ref: 3D-PGR-4178-S

GIP (Human)

CAS: 100040-31-1

GIP (Gastric Inhibitory Polypeptide) is a peptide hormone that belongs to the family of incretin hormones. GIP has been shown to have an insulinotropic effect, which is mediated by its activation of glucose-dependent insulin release from pancreatic β-cells. It also has effects on lipid metabolism and plays a role in the regulation of food intake. GIP is produced by K cells in the ileum and colon and released into the bloodstream following food intake. The binding of GIP to its receptors leads to inhibition of gastric acid secretion, stimulation of gallbladder contraction, increased blood flow to the stomach, relaxation of pyloric sphincter muscles, and inhibition of gastric motility. This product is highly pure (> 98%) with no detectable endotoxin or other microbial contamination.

Formula: C₂₂₆H₃₃₈N₆₀O₆₆S

Purity: Min. 95%

Molecular weight: 4,983.5 g/mol

Ref: 3D-PGR-4178-V