CAS 1000599-06-3

Formula: C31H33Cl2FN4O5S

InChI: InChI=1S/C24H25Cl2FN4O2.C7H8O3S/c1-31-9-14-5-13(6-15(14)10-31)11-33-21-8-19-16(7-20(21)32-2)24(29-12-28-19)30-18-4-3-17(25)22(26)23(18)27;1-6-2-4-7(5-3-6)11(8,9)10/h3-4,7-8,12-15H,5-6,9-11H2,1-2H3,(H,28,29,30);2-5H,1H3,(H,8,9,10)/t13?,14-,15+;

InChI key: GQLLAIBEWDUUBQ-XZPOUAKSSA-N

SMILES: CC1=CC=C(C=C1)S(=O)(=O)O.CN1C[C@H]2CC(C[C@H]2C1)COC3=C(C=C4C(=C3)N=CN=C4NC5=C(C(=C(C=C5)Cl)Cl)F)OC

4-Quinazolinamine, N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-[[(3aα,5β,6aα)-octahydro-2-methylcyclopenta[c]pyrrol-5-yl]methoxy]-, , 4-methylbenzenesulfonate (1:1)

CAS: 1000599-06-3

Formula: C₃₁H₃₃Cl₂FN₄O₅S

Molecular weight: 663.5869

Ref: IN-DA0000S6

Tesevatinib tosylate

CAS: 1000599-06-3

Tesevatinib tosylate (XL-647 tosylate) is an orally administered epidermal growth factor receptor (EGFR) inhibitor that can cross the blood-brain barrier. It significantly reduces cell viability with IC₅₀ values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Additionally, Tesevatinib tosylate inhibits HER2 (IC₅₀=16.1 nM), VEGFR2 (IC₅₀=1.5 nM), and Src (IC₅₀=10.3 nM), demonstrating antitumor activity by inhibiting tumor proliferation.

Formula: C₃₁H₃₃Cl₂FN₄O₅S

Color and Shape: Solid

Molecular weight: 663.59

Ref: TM-T201865