CAS 1000998-59-3

BMS-687453

Description:

BMS-687453, with the CAS number 1000998-59-3, is a chemical compound that has been studied primarily for its potential therapeutic applications, particularly in the field of oncology. It is classified as a small molecule inhibitor, specifically targeting certain pathways involved in cancer cell proliferation and survival. The compound exhibits selective inhibition of specific kinases, which are enzymes that play critical roles in various cellular processes, including signal transduction and cell division. BMS-687453 has shown promise in preclinical studies, demonstrating efficacy against certain cancer types by disrupting the signaling pathways that promote tumor growth. Its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are essential for determining its suitability for clinical use. Additionally, ongoing research aims to elucidate its safety profile and potential side effects, which are crucial for evaluating its therapeutic index. Overall, BMS-687453 represents a significant area of interest in drug development aimed at improving cancer treatment outcomes.

Formula: C₂₂H₂₁ClN₂O₆

Synonyms:

• CS-1533
• N-[[3-[[2-(4-Chlorophenyl)-5-methyl-4-oxazolyl]methoxy]phenyl]methyl]-N-(methoxycarbonyl)glycine
• 2-[[3-[[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy]phenyl]methyl-methoxycarbonylamino]acetic acid
• BMS-687453
• Glycine, N-[[3-[[2-(4-chlorophenyl)-5-methyl-4-oxazolyl]methoxy]phenyl]methyl]-N-(methoxycarbonyl)-
• BMS-687453;BMS687453;BMS 687453
• N-(3-{[2-(4-Chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy}benzyl)-N-(methoxycarbonyl)glycine

Glycine, N-[[3-[[2-(4-chlorophenyl)-5-methyl-4-oxazolyl]methoxy]phenyl]methyl]-N-(methoxycarbonyl)-

CAS: 1000998-59-3

Formula: C₂₂H₂₁ClN₂O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 444.8649

Ref: IN-DA0000WV

N-(3-((2-(4-Chlorophenyl)-5-Methyloxazol-4-Yl)Methoxy)Benzyl)-N-(Methoxycarbonyl)Glycine

CAS: 1000998-59-3

N-(3-((2-(4-Chlorophenyl)-5-Methyloxazol-4-Yl)Methoxy)Benzyl)-N-(Methoxycarbonyl)Glycine

Purity: 98%

Molecular weight: 444.87g/mol

Ref: 54-OR1024347

BMS-687453

CAS: 1000998-59-3

BMS-687453

Purity: ≥98%

Molecular weight: 444.86g/mol

Ref: 54-BUP04924

BMS-687453

CAS: 1000998-59-3

BMS-687453 is a potent and selective PPAR alpha agonist, with an EC(50) of 10 nM for human PPARalpha and approximately 410-fold selectivity vs human PPARgamma

Formula: C₂₂H₂₁ClN₂O₆

Purity: 99.4%

Color and Shape: Solid

Molecular weight: 444.86

Ref: TM-T5532

BMS-687453

CAS: 1000998-59-3

BMS-687453 is an amide compound that inhibits the activity of creatine kinase and targets the expression of genes involved in lipid metabolism. It has been shown to be effective in treating type 2 diabetes by lowering blood sugar levels. BMS-687453 also reduces serum urea nitrogen and phenylpropionic acid, which are metabolites of amino acids. BMS-687453 can activate low-density lipoprotein cholesterol, thereby reducing the risk of atherosclerosis. It is also an inhibitor of diabetic neuropathy and it has been shown to reduce pain perception in animal models. The mechanism by which BMS-687453 reduces pain may be due to its ability to inhibit the production and release of inflammatory cytokines such as TNF-α and IL-1β through activation of nuclear hormone receptors.

Formula: C₂₂H₂₁ClN₂O₆

Purity: Min. 95%

Molecular weight: 444.86 g/mol

Ref: 3D-AQB99859