CAS 1001264-89-6

GDC 0068

Description:

GDC-0068, also known as GDC-0068 or GDC-0068, is a small molecule inhibitor primarily targeting the protein kinase AKT, which plays a crucial role in various cellular processes, including metabolism, proliferation, and survival. This compound is particularly significant in cancer research, as aberrant AKT signaling is often associated with tumor growth and resistance to therapies. GDC-0068 exhibits high selectivity for AKT isoforms, making it a valuable tool in studying the AKT signaling pathway and its implications in oncogenesis. The substance is typically characterized by its ability to inhibit AKT phosphorylation, thereby disrupting downstream signaling pathways that contribute to cancer cell survival and proliferation. In preclinical studies, GDC-0068 has shown promise in enhancing the efficacy of other anticancer agents, indicating its potential as a combination therapy. Its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are essential for determining its therapeutic window and safety profile in clinical applications. Overall, GDC-0068 represents a significant advancement in targeted cancer therapies focused on the AKT pathway.

Formula: C₂₄H₃₂ClN₅O₂

InChI: InChI=1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7,14-16,19-20,26,31H,8-13H2,1-3H3/t16-,19-,20-/m1/s1

InChI key: InChIKey=GRZXWCHAXNAUHY-NSISKUIASA-N

SMILES: C[C@H]1C2=C(N=CN=C2[C@H](O)C1)N3CCN(C([C@H](CNC(C)C)C4=CC=C(Cl)C=C4)=O)CC3

Synonyms:

• 1-Propanone, 2-(4-chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-, (2S)-
• Gdc-0068
• Ipatasertib
• Rg 7440
• Rg7440
• (2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone
• (2s)-2-(4-chlorophenyl)-1-(4-((5r,7r)-6,7-dihydro-7-hydroxy-5-methyl-5h-cyclopentapyrimidin-4-yl)-1-piperazinyl)-3-((1-methylethyl)amino)-1-propanone

1-Propanone, 2-(4-chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-, (2S)-

CAS: 1001264-89-6

Formula: C₂₄H₃₂ClN₅O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 457.9962

Ref: IN-DA00010C

Ipatasertib

CAS: 1001264-89-6

Ipatasertib

Purity: ≥98%

Molecular weight: 458g/mol

Ref: 54-BUP10087

Ipatasertib

CAS: 1001264-89-6

Ipatasertib (GDC-0068) is a selective, ATP-competitive pan-Akt inhibitor that can lead to p53-independent PUMA activation.Cost-effective and quality-assured.

Formula: C₂₄H₃₂ClN₅O₂

Purity: 98.28% - 99.21%

Color and Shape: Solid

Molecular weight: 458

Ref: TM-T6252

(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone

CAS: 1001264-89-6

Applications (2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone is a highly selective AKT inhibitor targeting Akt1, Akt2 and Akt3. Studies have shown its use in combination with vemurafenib (V118500), have demonstrated therapeutic value in the treatment of hyperproliferative disorders such as cancer.
References Jie, L., et al.: Clin. Cancer. Res., 10, 1078 (2013);

Formula: C₂₄H₃₂ClN₅O₂

Color and Shape: Light Orange

Molecular weight: 458.0

Ref: TR-C377870

Ipatasertib-D7

Controlled Product

CAS: 1001264-89-6

Formula: C₂₄H₂₅D₇ClN₅O₂

Color and Shape: Neat

Molecular weight: 465.02

Ref: TR-C377872

Ipatasertib

CAS: 1001264-89-6

Ipatasertib is a drug that belongs to the class of inhibitors of the ATP-binding cassette (ABC) transporter protein P-glycoprotein. It prevents the efflux of drugs from cancer cells, thereby increasing their concentration in tumor tissue. Ipatasertib has been shown to be effective against eye disorders with minimal toxicity in vitro and in vivo. The drug binds to the bicylcic heterocycle as a result of its activity as an ATPase inhibitor and blocks tumor growth by inhibiting receptor activity.

Formula: C₂₄H₃₂ClN₅O₂

Purity: Min. 95%

Molecular weight: 458 g/mol

Ref: 3D-FC43222