
CAS 1005275-19-3
:Formula:C22H19ClF3NO3
InChI:InChI=1S/C22H19ClF3NO3/c23-13-8-15-17-10-4-5-11(6-10)18(17)19(27-20(15)16(9-13)21(28)29)12-2-1-3-14(7-12)30-22(24,25)26/h1-3,7-11,17-19,27H,4-6H2,(H,28,29)
InChI key:MDYBVKDISQFLKR-UHFFFAOYSA-N
SMILES:C1CC2CC1C3C2C4=C(C(=CC(=C4)Cl)C(=O)O)NC3C5=CC(=CC=C5)OC(F)(F)F
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KLHDC2-IN-1
CAS:KLHDC2-IN-1 (Compound 6) is a ligand that specifically targets the ubiquitin E3 ligase KLHDC2 with a dissociation constant (Kd) of 160 nM. It can be synthesized into a PROTAC capable of effectively degrading BRD4 within cells.Formula:C22H19ClF3NO3Color and Shape:SolidMolecular weight:437.84
