CAS 1005504-62-0

Formula: C21H23Cl2N5O

InChI: InChI=1S/C21H23Cl2N5O/c22-15-3-1-4-16(23)14(15)11-28-9-7-13(8-10-28)12-29-18-6-2-5-17-19(18)20(24)27-21(25)26-17/h1-6,13H,7-12H2,(H4,24,25,26,27)

InChI key: MNLHFGXIUJNDAF-UHFFFAOYSA-N

SMILES: C1CN(CCC1COC2=CC=CC3=C2C(=NC(=N3)N)N)CC4=C(C=CC=C4Cl)Cl

Rg3039

CAS: 1005504-62-0

Rg3039

Formula: C₂₁H₂₃Cl₂N₅O

Purity: 99.5%

Molecular weight: 432.35

Ref: 54-BUP05919

Rg3039

CAS: 1005504-62-0

Rg3039 (PF-06687859) is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy (SMA). RG3039 improves motor function in SMA mice.

Formula: C₂₁H₂₃Cl₂N₅O

Purity: 98.24% - 99.58%

Color and Shape: White Solid

Molecular weight: 432.346

Ref: TM-T3336

RG3039

CAS: 1005504-62-0

5-((1-(2,6-Dichlorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine

Formula: C₂₁H₂₃Cl₂N₅O

Purity: 98%

Molecular weight: 432.35

Ref: IN-DG304092

RG3039

CAS: 1005504-62-0

RG3039 is a novel small molecule that has been shown to have anti-leukemic activity in vitro and in vivo. RG3039 binds to the splicing machinery of the RNA spliceosome, which is essential for regulating gene expression. It also inhibits the phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) and reduces global protein synthesis. This drug also has an effect on primary cells from patients with AML or MDS and inhibits leukemia cell proliferation. The effective dose for RG3039 was found to be around 10 μM for human cells, but this may vary depending on the cell type. The safety profile of RG3039 appears to be favorable in preclinical studies, with no signs of toxicity observed up to a dose of 50 μM.
RG3039 is a novel small molecule that has been shown to have anti-leukemic activity in vitro and in vivo. RG3039 binds to the splicing machinery of

Formula: C₂₁H₂₃Cl₂N₅O

Purity: Min. 95%

Molecular weight: 432.35 g/mol

Ref: 3D-FQB50462

2,4-Quinazolinediamine, 5-[[1-[(2,6-dichlorophenyl)methyl]-4-piperidinyl]methoxy]-

CAS: 1005504-62-0

Formula: C₂₁H₂₃Cl₂N₅O

Purity: 95%

Color and Shape: Solid

Molecular weight: 432.3462

Ref: IN-DA0002AS