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CAS 100643-71-8

:

desloratadine

Description:
Desloratadine is a second-generation antihistamine primarily used to alleviate allergy symptoms such as sneezing, runny nose, and itchy eyes. It is a metabolite of loratadine and functions as a selective antagonist of peripheral H1 receptors, which helps reduce allergic responses without causing significant sedation, a common side effect of first-generation antihistamines. Desloratadine is characterized by its high oral bioavailability and long half-life, allowing for once-daily dosing. It is typically administered in the form of tablets or syrup and is well-tolerated, with a low incidence of adverse effects. The chemical structure of desloratadine includes a piperidine ring, contributing to its pharmacological properties. It is also known for its minimal interaction with the central nervous system, making it a preferred choice for individuals who need to avoid drowsiness. Overall, desloratadine is an effective and safe option for managing allergic conditions.
Formula:C19H19ClN2
InChI:InChI=1/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
InChI key:InChIKey=JAUOIFJMECXRGI-UHFFFAOYSA-N
SMILES:ClC=1C=C2C(C(C=3C(CC2)=CC=CN3)=C4CCNCC4)=CC1
Synonyms:
  • 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 8-chloro-6,11-dihydro-11-(4-piperidinylidene)-
  • 8-Chloro-11-(4-piperidylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
  • 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
  • 8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
  • Aerius
  • Allex
  • Azomyr
  • Clarinex
  • Dasselta
  • Delopedil
  • See more synonyms
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