CAS 100643-71-8

desloratadine

Description:

Desloratadine is a second-generation antihistamine primarily used to alleviate allergy symptoms such as sneezing, runny nose, and itchy eyes. It is a metabolite of loratadine and functions as a selective antagonist of peripheral H1 receptors, which helps reduce allergic responses without causing significant sedation, a common side effect of first-generation antihistamines. Desloratadine is characterized by its high oral bioavailability and long half-life, allowing for once-daily dosing. It is typically administered in the form of tablets or syrup and is well-tolerated, with a low incidence of adverse effects. The chemical structure of desloratadine includes a piperidine ring, contributing to its pharmacological properties. It is also known for its minimal interaction with the central nervous system, making it a preferred choice for individuals who need to avoid drowsiness. Overall, desloratadine is an effective and safe option for managing allergic conditions.

Formula: C₁₉H₁₉ClN₂

InChI: InChI=1/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2

InChI key: InChIKey=JAUOIFJMECXRGI-UHFFFAOYSA-N

SMILES: ClC=1C=C2C(C(C=3C(CC2)=CC=CN3)=C4CCNCC4)=CC1

Synonyms:

• 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 8-chloro-6,11-dihydro-11-(4-piperidinylidene)-
• 8-Chloro-11-(4-piperidylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
• 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
• 8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
• Aerius
• Allex
• Azomyr
• Clarinex
• Dasselta
• Delopedil
• Descarboethoxyloratadine
• Descarboethoxyloratidine
• Desler
• Eurodesa
• NSC 675447
• Neoclarityn
• Opulis
• Sch 34117
• Sedno
• Sch-34117, 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-β]pyridine, Clairinex, Aerius
• DESLORATADINE
• Clarinex(R), 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2,b]pyridine
• 8-chloro-6,11-dihydro-11-(4-piperdinylidene)-5h-benzo[5,6]cyclohepta[1,2-b]pyridine
• Dis-loratadine
• DESLORATIDINE
• AKOS 92131

Desloratadine - Bio-X ™

CAS: 100643-71-8

Desloratadine is a tricyclic antihistamine used in the treatment of seasonal allergies, rhinitis and pruritus. This drug binds with H1 receptors blocking the action of endogenous histamine. This leads to a relief in the negative symptoms caused by histamine such as nasal congestion.

Formula: C₁₉H₁₉ClN₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 310.82 g/mol

Ref: 3D-BD164361

Desloratadine

CAS: 100643-71-8

Histamine (H1) receptor antagonist; anti-inflammatory

Formula: C₁₉H₁₉ClN₂

Purity: Min. 95%

Color and Shape: Off-White Powder

Molecular weight: 310.82 g/mol

Ref: 3D-FD21213

Rupatadine EP impurity B

CAS: 100643-71-8

Formula: C₁₉H₁₉ClN₂

Molecular weight: 310.8

Ref: ST-EA-CP-R4014