CAS 10078-25-8

Perphenazine sulfoxide

Description:

Perphenazine sulfoxide is a chemical compound derived from perphenazine, which is an antipsychotic medication. It is characterized by the presence of a sulfoxide functional group, which introduces unique properties compared to its parent compound. The molecular structure typically includes a phenothiazine core, which is common in many antipsychotic drugs, and the sulfoxide group enhances its pharmacological profile. Perphenazine sulfoxide is known for its potential use in psychiatric treatment, exhibiting antipsychotic and antiemetic effects. It is generally a solid at room temperature and may have varying solubility in different solvents, which is influenced by the presence of the sulfoxide group. The compound's stability, reactivity, and biological activity can be affected by factors such as pH and temperature. As with many pharmaceuticals, safety and efficacy are critical, and its use should be guided by clinical evidence and regulatory standards. Overall, perphenazine sulfoxide represents an important compound in medicinal chemistry, particularly in the context of neuropharmacology.

Formula: C₂₁H₂₆ClN₃O₂S

InChI: InChI=1S/C21H26ClN3O2S/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)28(21)27)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2

InChI key: InChIKey=WXJXTMQMAOYROI-UHFFFAOYSA-N

SMILES: C(CCN1CCN(CCO)CC1)N2C=3C(S(=O)C=4C2=CC=CC4)=CC=C(Cl)C3

Synonyms:

• 1-Piperazineethanol, 4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-, S-oxide
• 1-Piperazineethanol, 4-[3-(2-chloro-5-oxido-10H-phenothiazin-10-yl)propyl]-
• 1-Piperazineethanol, 4-[3-(2-chlorophenothiazin-10-yl)propyl]-, S-oxide
• 2-Chloro-10-(3-(4-(2-Hydroxyethyl)-7-Piperazinyl)Propyl)Phenothiazine
• 2-{4-[3-(2-chloro-5-oxido-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethanol
• 4-(3-(2-Chlorophenothiazin-10-Yl)Propyl)-1-Piperazineethanosulfoxide
• 4-[3-(2-Chloro-5-oxido-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol
• Ethaperazine sulfoxide
• Perphenazine sulfoxide

Perphenazine Sulfoxide

CAS: 10078-25-8

Compounds (excluding drugs) containing a phenothiazine ring-system (whether or not hydrogenated), not further fused

Formula: C₂₁H₂₆ClN₃O₂S

Color and Shape: White Crystalline Powder

Molecular weight: 419.14343

Ref: 45-1511203

Perphenazine Sulfoxide

CAS: 10078-25-8

Ref: IN-DA008XK6

Perphenazine sulfoxide

CAS: 10078-25-8

Perphenazine sulfoxide

Purity: 98%

Ref: 54-OR1037173

Perphenazine EP Impurity A

CAS: 10078-25-8

Formula: C₂₁H₂₆ClN₃O₂S

Color and Shape: White To Off-White Solid

Molecular weight: 419.97

Ref: 4Z-P-209

2-[4-[3-(2-Chloro-5-oxido-10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethanol (Perphenazine Sulphoxide)

Controlled Product

CAS: 10078-25-8

Formula: C₂₁H₂₆ClN₃O₂S

Color and Shape: Neat

Molecular weight: 419.97

Ref: 86-MM0826.01

Perphenazine Sulfoxide

Controlled Product

CAS: 10078-25-8

Impurity Perphenazine EP Impurity A
Applications Perphenazine Sulfoxide (Perphenazine EP Impurity A) acts as a D2 dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic. Inhibits glutamate dehydrogenase in vitro. Antipsychotic.
References Gaertner, H.J., et al.: Drug Metab. Dispos., 3, 437 (1975), O Brien, S., et al.: J. Med. Chem., 48, 1287 (2005), Briggs, K., et al.: Toxicology, 231, 113 (2007), Toga, T., et al.: J. Pharmacol. Sci., 105, 207 (2007),

Formula: C₂₁H₂₆ClN₃O₂S

Color and Shape: Neat

Molecular weight: 419.97

Ref: TR-P291105

Perphenazine EP Impurity A

CAS: 10078-25-8

Formula: C₂₁H₂₆ClN₃O₂S

Molecular weight: 420

Ref: ST-EA-CP-P168001