CAS 100846-24-0

5-(Trifluoromethyl)indole

Description:

5-(Trifluoromethyl)indole is an organic compound characterized by the presence of an indole ring substituted with a trifluoromethyl group at the 5-position. The indole structure consists of a fused benzene and pyrrole ring, contributing to its aromatic properties and potential biological activity. The trifluoromethyl group, which is a highly electronegative substituent, significantly influences the compound's chemical reactivity and lipophilicity, often enhancing its pharmacological properties. This compound is typically a solid at room temperature and is known for its stability under various conditions, although it may undergo reactions typical of indole derivatives, such as electrophilic substitution. Its unique structure makes it of interest in medicinal chemistry, particularly in the development of pharmaceuticals and agrochemicals. Additionally, the presence of fluorine atoms can improve metabolic stability and bioavailability, making it a valuable scaffold in drug design. Safety and handling precautions should be observed due to the potential toxicity associated with fluorinated compounds.

Formula: C₈H₇BrFNO

InChI: InChI=1/C8H7BrFNO/c1-5(12)11-8-3-2-6(10)4-7(8)9/h2-4H,1H3,(H,11,12)

SMILES: CC(=Nc1ccc(cc1Br)F)O

Synonyms:

• 1H-Indole, 5-(Triflu Oromethyl)- (9Ci)
• 5-Trifluoromethyl Indole ,98%
• N-(2-bromo-4-fluorophenyl)acetamide

5-(Trifluoromethyl)indole, 98%

CAS: 100846-24-0

In 3-Naphthylindole construction by rhodium (II)-catalyzed regioselective direct arylation of indoles with 1-diazonaphthalen-2-(1H)-ones treatment of 5-(trifluoromethyl)indole(1k) or 6-(trifluoromethyl)indole (1l) with 2a afforded the desired products 3k (86%)and 3l (86%).This Thermo Scientific Chem

Formula: C₉H₆F₃N

Purity: 98%

Color and Shape: Pale yellow to brown, Powder

Molecular weight: 185.15

Ref: 02-H28782

1H-Indole, 5-(trifluoromethyl)-

CAS: 100846-24-0

Formula: C₉H₆F₃N

Purity: 97%

Color and Shape: Solid

Molecular weight: 185.1458

Ref: IN-DA0002ZS

5-(Trifluoromethyl)-1H-indole

CAS: 100846-24-0

5-(Trifluoromethyl)-1H-indole

Formula: C₉H₆F₃N

Purity: 98%

Color and Shape: yellow powder

Molecular weight: 185.15g/mol

Ref: 54-PC3045

5-Trifluoromethylindole

CAS: 100846-24-0

Formula: C₉H₆F₃N

Molecular weight: 185.15

Ref: 7W-GK8275

5-(Trifluoromethyl)indole

CAS: 100846-24-0

Formula: C₉H₆F₃N

Purity: 97%

Color and Shape: Solid

Molecular weight: 185.149

Ref: 10-F216291

5-(Trifluoromethyl)indole

CAS: 100846-24-0

5-(Trifluoromethyl)indole is a useful scaffold, versatile building block, useful intermediate and reaction component. 5-(Trifluoromethyl)indole is a high quality reagent with many uses in research and as a speciality chemical. It is a complex compound that can be used as a building block for the synthesis of other chemicals.

Formula: C₉H₆F₃N

Purity: Min. 97.0 Area-%

Molecular weight: 185.15 g/mol

Ref: 3D-J-000232

5-(Trifluoromethyl)indole

CAS: 100846-24-0

5-(Trifluoromethyl)indole is an indole derivative that binds to both orthosteric and allosteric sites of the 5-HT receptor, which is a G protein-coupled receptor. The affinity of 5-(Trifluoromethyl)indole for the 5-HT receptor is approximately 10 times greater than for other receptors, making it a potent ligand. This compound has been shown to inhibit colitis in mice by binding to the 5-HT3 receptor and inhibiting calcium ion influx. It also inhibits deuterolysis and catalysis in cells at high concentrations. Research on this drug has shown that it can be used as an endogenous ligand for the 5-HT3 receptor, but its activity is not as potent as when it is used as a ligand.

Formula: C₉H₆F₃N

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 185.15 g/mol

Ref: 3D-FT37897