CAS 101224-22-0

Buprenorphine glucuronide

Description:

Buprenorphine glucuronide is a metabolite of buprenorphine, an opioid used primarily for pain management and in the treatment of opioid addiction. This compound is formed through the process of glucuronidation, where a glucuronic acid molecule is conjugated to buprenorphine, enhancing its solubility and facilitating excretion. Buprenorphine glucuronide is characterized by its relatively high molecular weight and specific structural features that include a morphinan backbone. It is typically found in biological fluids, such as urine, and is often measured in pharmacokinetic studies to assess buprenorphine metabolism. The presence of this metabolite can indicate recent buprenorphine use and is important in clinical and forensic toxicology. While it is less pharmacologically active than its parent compound, understanding its characteristics is crucial for interpreting drug tests and managing opioid therapy effectively. Its detection can also provide insights into the metabolic pathways of buprenorphine and the potential for drug interactions.

Formula:C₃₅H₄₉NO₁₀

InChI:InChI=1S/C35H49NO10/c1-31(2,3)32(4,42)20-15-33-10-11-35(20,43-5)30-34(33)12-13-36(16-17-6-7-17)21(33)14-18-8-9-19(26(46-30)22(18)34)44-29-25(39)23(37)24(38)27(45-29)28(40)41/h8-9,17,20-21,23-25,27,29-30,37-39,42H,6-7,10-16H2,1-5H3,(H,40,41)/t20-,21-,23+,24+,25-,27+,29-,30-,32+,33-,34+,35-/m1/s1

InChI key:InChIKey=CZULHKGIAJASAA-WWIHBJMFSA-N

SMILES:O(C)[C@@]12[C@]3([C@]45[C@@]([C@](N(CC6CC6)CC4)(CC7=C5C(O3)=C(O[C@@H]8O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]8O)C=C7)[H])(C[C@@]1([C@]([C@](C)(C)C)(C)O)[H])CC2)[H]

Synonyms:

(5,7)-17-(Cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-7-[(1S)-1-hydroxy-1,2,2,-trimethylpropyl]-6-methoxy-6,14-ethenomorphinan-3-yl -D-Glucuronide
(57-17-(Cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-7-[(1S)-1-hydroxy-1,2,2,-trimethylpropyl]-6-methoxy-6,14-ethenomorphinan-3-yl b-D-Glucuronide
(5alpha,6beta,14beta,18R)-17-(cyclopropylmethyl)-18-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-2-yl beta-D-glucopyranosiduronic acid
(5α,7α)-17-(Cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-7-[(1S)-1-hydroxy-1,2,2-trimethylpropyl]-6-methoxy-6,14-ethenomorphinan-3-yl β-D-glucopyranosiduronic acid
Buprenorphine -D-Glucuronide
Buprenorphine 3-glucuronide
Buprenorphine 3-β-D-glucuronide
Buprenorphine glucuronide
buprenorphine-3-O-glucuronide
β-D-Glucopyranosiduronic acid, (5α,7α)-17-(cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-7-[(1S)-1-hydroxy-1,2,2-trimethylpropyl]-6-methoxy-6,14-ethenomorphinan-3-yl
Buprenorphine 3-β-D-glucuronide
β-D-Glucopyranosiduronic acid, (5α,7α)-17-(cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-7-[(1S)-1-hydroxy-1,2,2-trimethylpropyl]-6-methoxy-6,14-ethenomorphinan-3-yl
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Brand

LGC(2)Lipomed(4)TRC(2)

Solvent

Methanol(2)Water(2)

Found 8 products.

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Buprenorphine-3-Beta-D-glucuronide
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 101224-22-0
Formula:C₃₅H₄₉NO₁₀
Color and Shape:Neat
Molecular weight:643.76
Ref: LP-BUP-1714
10mg
1,593.00€
VAT not included
50mg
6,037.00€
VAT not included
100mg
10,255.00€
VAT not included
+ Info
Buprenorphine-3-β-D-glucuronide, 0.1mg/ml in Methanol
CAS:
- 101224-22-0
Formula:C₃₅H₄₉NO₁₀
Color and Shape:Colourless
Molecular weight:643.76
Ref: LP-BUP-1714-0.1LM
1ml
230.00€
VAT not included
+ Info
Buprenorphine 3-beta-D-Glucuronide
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 101224-22-0
Formula:C₃₅H₄₉NO₁₀
Color and Shape:White To Off-White
Molecular weight:643.76
Ref: 61-FOR0120.14
5mg
175.00€
VAT not included
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Buprenorphine 3-β-D-Glucuronide 0.1 mg/ml in Methanol
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 101224-22-0
Formula:C₃₅H₄₉NO₁₀
Color and Shape:Colourless
Molecular weight:643.76
Ref: 61-AMP0120.14-02
1ml
477.00€
VAT not included
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Buprenorphine-3-β-D-glucuronide, 1mg/ml in Water
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 101224-22-0
Formula:C₃₅H₄₉NO₁₀
Color and Shape:Colourless
Molecular weight:643.76
Ref: LP-BUP-1714-1LAH
1ml
To inquire
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Buprenorphine-3-β-D-glucuronide, 1mg/ml in Water
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 101224-22-0
Formula:C₃₅H₄₉NO₁₀
Color and Shape:Colourless
Molecular weight:643.76
Ref: LP-BUP-1714-1LH
1ml
581.00€
VAT not included
+ Info
Buprenorphine beta-D-Glucuronide
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 101224-22-0
Applications A metabolite of Buprenorphine (B689570). Controlled substance.
References Rolleri, E., et al.: Clin. Chim. Acta, 66, 319 (1976), Moore, R.A., et al.: Ann. Clin. Biochem., 21, 318 (1984),
Formula:C₃₅H₄₉NO₁₀
Color and Shape:Neat
Molecular weight:643.76
Ref: TR-B689580
500µg
396.00€
VAT not included
1mg
636.00€
VAT not included
10mg
4,465.00€
VAT not included
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Buprenorphine β-D-Glucuronide (100ug/ml in Methanol)
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 101224-22-0
Formula:C₃₅H₄₉NO₁₀
Color and Shape:Single Solution
Molecular weight:643.76
Ref: TR-KIT0670
1x1ml
933.00€
VAT not included