CAS 101530-10-3

Lanoconazole

Description:

Lanoconazole is an antifungal agent primarily used in the treatment of superficial fungal infections. It belongs to the class of imidazole derivatives and exhibits broad-spectrum antifungal activity against various dermatophytes and yeast. The chemical structure of lanoconazole features a triazole ring, which is crucial for its mechanism of action, as it inhibits the enzyme lanosterol 14α-demethylase, disrupting ergosterol synthesis in fungal cell membranes. This disruption leads to increased membrane permeability and ultimately cell death. Lanoconazole is typically administered topically, making it effective for localized infections with minimal systemic absorption. Its pharmacokinetic profile indicates a relatively low toxicity, which contributes to its safety in clinical use. Additionally, lanoconazole has shown efficacy in treating conditions such as tinea, candidiasis, and other dermatological fungal infections. Its formulation may include creams, lotions, or solutions, allowing for versatile application depending on the infection site. Overall, lanoconazole is a valuable agent in the antifungal therapeutic arsenal, particularly for dermatological applications.

Formula: C₁₄H₁₀ClN₃S₂

InChI: InChI=1/C14H10ClN3S2/c15-11-4-2-1-3-10(11)13-8-19-14(20-13)12(7-16)18-6-5-17-9-18/h1-6,9,13H,8H2/b14-12+

InChI key: InChIKey=ZRTQSJFIDWNVJW-WYMLVPIENA-N

SMILES: C(\C#N)(=C/1\SC(CS1)C2=C(Cl)C=CC=C2)/N3C=CN=C3

Synonyms:

• (2Z)-[4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene](1H-imidazol-1-yl)ethanenitrile
• (αE)-α-[4-(2-Chlorophenyl)-1,3-dithiolan-2-ylidene]-1H-imidazole-1-acetonitrile
• 1H-Imidazole-1-acetonitrile, α-[4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene]-, (E)-
• 1H-Imidazole-1-acetonitrile, α-[4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene]-, (αE)-
• 2E)-[4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene](1H-imidazol-1-yl)ethanenitrile
• Astat
• Latoconazole
• Nnd 318
• Tjn 318
• Lanoconazole

1H-Imidazole-1-acetonitrile, α-[4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene]-, (αE)-

CAS: 101530-10-3

Formula: C₁₄H₁₀ClN₃S₂

Purity: 98.00%

Color and Shape: Solid

Molecular weight: 319.8323

Ref: IN-DA0004QG

Lanoconazole

CAS: 101530-10-3

Formula: C₁₄H₁₀ClN₃S₂

Molecular weight: 319.83

Ref: 7W-GP0322

Lanoconazole

Controlled Product

CAS: 101530-10-3

Formula: C₁₄H₁₀ClN₃S₂

Color and Shape: Neat

Molecular weight: 319.83

Ref: 04-C14592300

Lanoconazole

CAS: 101530-10-3

Lanoconazole is an antifungal imidazole that is potent and orally available and acts by inhibiting the synthesis of ergosterol in fungal cell membranes.

Formula: C₁₄H₁₀ClN₃S₂

Purity: 98% - 98%

Color and Shape: Light-Yellow Crystals

Molecular weight: 319.83

Ref: TM-T15708

Lanoconazole RS

CAS: 101530-10-3

Color and Shape: White

Ref: 2K-1179100021

Lanoconazole

CAS: 101530-10-3

Anti-fungal; sterol demethylase inhibitor

Formula: C₁₄H₁₀ClN₃S₂

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 319.83 g/mol

Ref: 3D-FL24836

Lanoconazole

Controlled Product

CAS: 101530-10-3

Applications Antifungal.
References Oka, H., et al.: Arzneim.-Forsch., 42, 345 (1992), Niwano, Y., et al.: Antimicrob. Agents Chemother., 38, 2204 (1994), Munt, L.: et al.: Oyo Yakuri, 43, 195 (1992),

Formula: C₁₄H₁₀ClN₃S₂

Color and Shape: Neat

Molecular weight: 319.83

Ref: TR-L174500