CAS 1015787-98-0
:Gefapixant
Description:
Gefapixant, identified by its CAS number 1015787-98-0, is a novel chemical compound primarily developed for therapeutic use in treating chronic cough. It functions as a selective P2X3 receptor antagonist, which plays a crucial role in the sensory pathways associated with cough reflex. This mechanism of action helps to reduce the hypersensitivity of the cough reflex, making it a potential treatment option for patients suffering from chronic cough conditions. Gefapixant is characterized by its relatively low molecular weight and specific structural features that enable its interaction with the P2X3 receptor. The compound has undergone various clinical trials to assess its efficacy and safety profile, showing promise in alleviating cough symptoms without the sedative effects commonly associated with other cough suppressants. As with many pharmacological agents, its development has included extensive studies on pharmacokinetics, metabolism, and potential side effects to ensure its therapeutic viability. Overall, gefapixant represents a targeted approach to managing chronic cough, highlighting the importance of receptor-specific therapies in modern medicine.
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Found 5 products.
5-[(2,4-diaminopyrimidin-5-yl)oxy]-2-methoxy-4-(propan-2-yl)benzene-1-sulfonamide
CAS:Formula:C14H19N5O4SPurity:99%Molecular weight:353.3968Gefapixant
CAS:Gefapixant (AF219) is a P2X3 receptor (P2X3R) antagonist with IC50 of ~30 nM at recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptorsFormula:C14H19N5O4SPurity:99.28% - 99.50%Color and Shape:SolidMolecular weight:353.4Gefapixant
CAS:<p>Reversible allosteric antagonist at human P2X3 and P2X2/3 receptors</p>Formula:C14H19N5O4SPurity:Min. 98 Area-%Color and Shape:White Off-White PowderMolecular weight:353.4 g/mol
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