CAS 101622-51-9

Olomoucine

Description:

Olomoucine is a chemical compound recognized for its role as a selective inhibitor of cyclin-dependent kinases (CDKs), particularly CDK2. It is classified as a purine derivative and is often utilized in biochemical research to study cell cycle regulation and cancer biology. The compound exhibits a relatively low molecular weight and possesses a specific structure that allows it to effectively bind to the ATP-binding site of CDKs, thereby inhibiting their activity. This inhibition can lead to cell cycle arrest, making Olomoucine a valuable tool in the investigation of therapeutic strategies for cancer treatment. Additionally, Olomoucine has been studied for its potential effects on various cellular processes, including apoptosis and differentiation. Its selectivity for CDKs over other kinases is a significant characteristic, allowing for targeted studies without broad-spectrum kinase inhibition. As with many research chemicals, proper handling and safety precautions are essential when working with Olomoucine in laboratory settings.

Formula: C₁₅H₁₈N₆O

InChI: InChI=1S/C15H18N6O/c1-21-10-18-12-13(17-9-11-5-3-2-4-6-11)19-15(16-7-8-22)20-14(12)21/h2-6,10,22H,7-9H2,1H3,(H2,16,17,19,20)

InChI key: InChIKey=GTVPOLSIJWJJNY-UHFFFAOYSA-N

SMILES: N(CC1=CC=CC=C1)C2=C3C(=NC(NCCO)=N2)N(C)C=N3

Synonyms:

• 2-(2-Hydroxyethylamino)-6-Benzylamino-9-Methylpurine
• 2-(2′-Hydroxyethylamino)-9-methyl-6-(benzylamino)purine
• 2-(6-Benzylamino-9-methyl-9H-purin-2-ylamino)-ethanol
• 2-[[6-(Benzylamino)-9-methylpurin-2-yl]amino]ethanol
• 2-[[9-Methyl-6[(Phenylmethyl)Amino]-9H-Purin-2-Yl]Amino]-Ethanol
• 2-{[6-(benzylamino)-9-methyl-9H-purin-2-yl]amino}ethanol
• 6-Benylamino-2-(2-Hydroxyethylamino)-9-Methylpurine
• 6-Benzylamino-2-(2-Hydroxyethylamino)-9-Methylpurine
• Ethanol, 2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-
• N2-[(2-Hydroxyethyl)]-N6-Benzyladenine
• NSC 666096
• Olomoucine Synthetic >95%

Ethanol, 2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-

CAS: 101622-51-9

Formula: C₁₅H₁₈N₆O

Purity: 99%

Color and Shape: Solid

Molecular weight: 298.3430

Ref: IN-DA0004Z8

Olomoucine

CAS: 101622-51-9

2-((6-(Benzylamino)-9-methyl-9H-purin-2-yl)amino)ethanol

Formula: C₁₅H₁₈N₆O

Purity: 99%

Molecular weight: 298.34

Ref: IN-DG146190

Olomoucine

CAS: 101622-51-9

Formula: C₁₅H₁₈N₆O

Purity: (as N) ≥ 98.0%

Color and Shape: White to off-white powder or solid

Molecular weight: 298.35

Ref: 7W-GK8269

Olomoucine

CAS: 101622-51-9

Olomoucine

Formula: C₁₅H₁₈N₆O

Purity: ≥98%

Molecular weight: 298.34

Ref: 54-BUP12121

Olomoucine

CAS: 101622-51-9

Olomoucine hinders Cdk2, Cdc2, CDK5, ERK1, regulates the cell cycle, and fights melanoma; IC50s: 3-25 µM.

Formula: C₁₅H₁₈N₆O

Purity: 99.77%

Color and Shape: White Crystalline Powder

Molecular weight: 298.34

Ref: TM-T21588

Olomoucine

CAS: 101622-51-9

Olomoucine

Formula: C₁₅H₁₈N₆O

Purity: 99%

Color and Shape: White to off white Solid-Powder

Molecular weight: 298.34302

Ref: 54-BIO3107

Olomoucine-d3

Controlled Product

CAS: 101622-51-9

Applications Olomoucine-d3 is the labeled analogue of Olomoucine (O567000), A purine derivative which inhibits cyclin-dependent kinases and induces G1 arrest.
References Vesely, J., et a.: Eur. J. Biochem., 224, 771 (1994), Abraham, R.T., et al.: Biol. Cell, 83, 105 (1995)

Formula: C₁₅D₃H₁₅N₆O

Color and Shape: Neat

Molecular weight: 301.36

Ref: TR-O567002

Olomoucine

CAS: 101622-51-9

Purity: 99%

Molecular weight: 298.154

Ref: 10-F865514