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CAS 101827-46-7

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Butenafine hydrochloride

Description:
Butenafine hydrochloride is an antifungal agent primarily used in the treatment of dermatophyte infections, such as athlete's foot and ringworm. It belongs to the class of compounds known as benzylamines and functions by inhibiting the enzyme squalene epoxidase, which is crucial in the biosynthesis of ergosterol, a vital component of fungal cell membranes. This disruption leads to the accumulation of toxic sterols and ultimately results in fungal cell death. Butenafine hydrochloride is typically administered topically, and its formulation may include various excipients to enhance skin penetration and stability. The compound is characterized by its white to off-white crystalline appearance and is soluble in organic solvents. Its safety profile indicates that it is generally well-tolerated, with minimal systemic absorption when used as directed. However, like all medications, it may cause localized skin reactions in some individuals. Overall, butenafine hydrochloride is an effective option for managing superficial fungal infections.
Formula:C23H27N·ClH
InChI:InChI=1S/C23H27N.ClH/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20;/h5-15H,16-17H2,1-4H3;1H
InChI key:InChIKey=LJBSAUIFGPSHCN-UHFFFAOYSA-N
SMILES:C(N(CC1=CC=C(C(C)(C)C)C=C1)C)C=2C3=C(C=CC2)C=CC=C3.Cl
Synonyms:
  • 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine
  • 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine hydrochloride (1:1)
  • 1-Naphthalenemethanamine, N-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-methyl-, hydrochloride
  • 1-Naphthalenemethanamine, N-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-methyl-, hydrochloride (1:1)
  • Butenafine Hydrochloride
  • Butenafine hydrochloide
  • ButenafineHCL
  • Kp-363
  • Mentax
  • N-((4-(1,1-Dimethylethyl)Phenyl)Methyl)-N-Methyl-1-Naphthalenemethanaminehyd
  • See more synonyms
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