CAS 1025967-78-5

Lifitegrast

Description:

Lifitegrast is a synthetic small molecule classified as a lymphocyte function-associated antigen-1 (LFA-1) antagonist. It is primarily used in the treatment of dry eye disease, a condition characterized by insufficient tear production and inflammation of the ocular surface. Lifitegrast works by inhibiting the interaction between LFA-1 on lymphocytes and intercellular adhesion molecule-1 (ICAM-1) on epithelial cells, thereby reducing inflammation and promoting ocular surface health. The substance is typically administered as an eye drop solution, allowing for localized action with minimal systemic absorption. Lifitegrast has been shown to improve symptoms of dry eye and enhance tear production in clinical studies. Its safety profile includes common side effects such as eye irritation and discomfort, but it is generally well-tolerated. As a relatively novel therapeutic agent, Lifitegrast represents a targeted approach to managing dry eye disease, addressing both symptoms and underlying inflammation.

Formula: C₂₉H₂₄Cl₂N₂O₇S

InChI: InChI=1S/C29H24Cl2N2O7S/c1-41(38,39)20-4-2-3-16(11-20)12-23(29(36)37)32-27(34)25-22(30)13-19-15-33(9-7-21(19)26(25)31)28(35)18-6-5-17-8-10-40-24(17)14-18/h2-6,8,10-11,13-14,23H,7,9,12,15H2,1H3,(H,32,34)(H,36,37)/t23-/m0/s1

InChI key: InChIKey=JFOZKMSJYSPYLN-QHCPKHFHSA-N

SMILES: ClC1=C2C(CN(C(=O)C=3C=C4C(=CC3)C=CO4)CC2)=CC(Cl)=C1C(N[C@@H](CC5=CC(S(C)(=O)=O)=CC=C5)C(O)=O)=O

Synonyms:

• N-[[2-(6-Benzofuranylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl]carbonyl]-3-(methylsulfonyl)-L-phenylalanine
• Xiidra
• Lifitegrast
• L-Phenylalanine, N-[[2-(6-benzofuranylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl]carbonyl]-3-(methylsulfonyl)-
• SAR 1118
• SHP-606
• Lifitegras
• Lifitegrast (This product is only available in Japan.)
• liftegrast
• Lifitegrast Impurity
• (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic
• Lifitegrast Lifitegrast API
• (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid
• SAR-1118;SAR1118
• Lifitegrast, SAR 1118
• Lifitegrast (Xiidra)
• Lifitegrast（API）
• CS-2633
• Lifitegrast-d4

L-Phenylalanine, N-[[2-(6-benzofuranylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl]carbonyl]-3-(methylsulfonyl)-

CAS: 1025967-78-5

Formula: C₂₉H₂₄Cl₂N₂O₇S

Purity: 97%

Color and Shape: Solid

Molecular weight: 615.4811

Ref: IN-DA0007UU

Lifitegrast

CAS: 1025967-78-5

Lifitegrast

Formula: C₂₉H₂₄Cl₂N₂O₇S

Purity: 99%

Molecular weight: 615.48

Ref: 54-OR1023624

rac-Lifitegrast-d4

CAS: 1025967-78-5

Formula: C₂₉H₂₀D₄Cl₂N₂O₇S

Molecular weight: 619.50

Ref: 4Z-L-153002

Lifitegrast

CAS: 1025967-78-5

Lifitegrast

Formula: C₂₉H₂₄Cl₂N₂O₇S

Purity: ≥98%

Molecular weight: 615.48

Ref: 54-BUP13176

Lifitegrast

CAS: 1025967-78-5

Formula: C₂₉H₂₄Cl₂N₂O₇S

Color and Shape: Off-White Solid

Molecular weight: 615.48

Ref: 4Z-L-153001

Lifitegrast

CAS: 1025967-78-5

Color and Shape: Neat

Ref: 86-MM3999.00

Lifitegrast

CAS: 1025967-78-5

Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist.

Formula: C₂₉H₂₄Cl₂N₂O₇S

Purity: 99.39% - 99.66%

Color and Shape: Solid

Molecular weight: 615.48

Ref: TM-T3977

Lifitegrast

CAS: 1025967-78-5

(S)-2-(2-(Benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Formula: C₂₉H₂₄Cl₂N₂O₇S

Purity: 97%

Molecular weight: 615.48

Ref: IN-DG758093

Lifitegrast

CAS: 1025967-78-5

Formula: C₂₉H₂₄Cl₂N₂O₇S

Molecular weight: 615.5

Ref: BE-RMCL088000

LIFITEGRAST

CAS: 1025967-78-5

Purity: 97%

Molecular weight: 615.4799805

Ref: 10-F807193

Lifitegrast

Controlled Product

CAS: 1025967-78-5

Applications Lifitegrast is used for the treatment of signs and symptons of dry eye diseases. It also Inhibites corneal inflammation that is capable of causing pains, blurred vision and ocular discomfort in sufferer.
References Holland, E. J., et al.: Curr. Med. Res. Opin., 32, 1759 (2016); Sun, Y., et al.: J. Ocul. Pharmacol. Ther., 29, 395 (2013);

Formula: C₂₉H₂₄Cl₂N₂O₇S

Color and Shape: Neat

Molecular weight: 615.481

Ref: TR-L465955

Lifitegrast-d4

Controlled Product

CAS: 1025967-78-5

Formula: C₂₉D₄H₂₀Cl₂N₂O₇S

Color and Shape: Neat

Molecular weight: 619.506

Ref: TR-L465957

Lifitegrast

CAS: 1025967-78-5

Formula: C₂₉H₂₄Cl₂N₂O₇S

Molecular weight: 615.48

Ref: ST-EA-CP-L68000

Lifitegrast

CAS: 1025967-78-5

Inhibits binding of lymphocyte function-associated antigen 1 (LFA-1) and intercellular adhesion molecule 1 (ICAM-1) surface integrins. The activity of lifitegrast on these proteins at the ocular surface leads to suppressed T-cell mediated inflammatory response involved in dry eye disease. This compound also has therapeutic potential for contact lens-related corneal infiltrates.

Formula: C₂₉H₂₄Cl₂N₂O₇S

Purity: Min. 95%

Color and Shape: White/Off-White To Yellow Solid

Molecular weight: 615.48 g/mol

Ref: 3D-FB146398