CAS 102805-45-8

(D-P-cl-phe6,leu17)-vasoactive*intestinal peptide

Description:

(D-P-Cl-Phe6,Leu17)-vasoactive intestinal peptide (VIP) is a synthetic analog of the naturally occurring vasoactive intestinal peptide, which is a neuropeptide involved in various physiological processes, including vasodilation, smooth muscle relaxation, and modulation of immune responses. This particular analog features specific amino acid substitutions that enhance its stability and biological activity. The presence of D-P-Cl-Phe at position 6 and Leu at position 17 contributes to its altered pharmacokinetic properties, potentially increasing its therapeutic efficacy. VIP and its analogs are known for their role in regulating gastrointestinal functions, promoting insulin secretion, and acting as neuroprotective agents. The compound is typically characterized by its peptide structure, which includes a sequence of amino acids linked by peptide bonds, and it may exhibit specific binding affinities to VIP receptors. Its CAS number, 102805-45-8, allows for precise identification in chemical databases and literature. Overall, this compound represents a significant interest in pharmacology and therapeutic applications, particularly in gastrointestinal and neuroendocrine disorders.

Formula: C₁₄₈H₂₃₉ClN₄₄O₄₂

Synonyms:

• (p-Chloro-D-Phe6,Leu17)-VIP (human, bovine, porcine, rat)
• H-His-Ser-Asp-Ala-Val-p-chloro-D-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Leu-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
• [D-P-Cl-Phe(6),Leu(17)]-Vasoactive Intestinal Peptide Human, Porcine, Rat

[D-p-Cl-Phe6,Leu17]-VIP

CAS: 102805-45-8

Selective vasoactive intestinal peptide (VIP) receptor antagonist (IC50 = 125.8 nM). Displays no activity on glucagon, secretin or GRF receptors.

Formula: C₁₄₈H₂₃₉ClN₄₄O₄₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 3342.24

Ref: TM-TP2103

(p-Chloro-D-Phe6,Leu17)-VIP (human, mouse, rat) trifluoroacetate salt

CAS: 102805-45-8

VIP is a potent vasoactive neuropeptide that is found in the heart, brain, and gut. It has been shown to be a potent inhibitor of guanethidine-induced contractions in the femoral vein, as well as atrial contractions. VIP also inhibits spontaneous contractions in the fundic region of the stomach and intestinal motility. VIP has been shown to inhibit vasoactive intestinal polypeptide-induced contractions in isolated rat ileum. VIP is expressed primarily in the enteric nervous system and throughout the gastrointestinal tract.

Formula: C₁₄₈H₂₃₉ClN₄₄O₄₂

Purity: Min. 95%

Molecular weight: 3,342.21 g/mol

Ref: 3D-FC109522