CAS 1032754-93-0

(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one

Description:

The chemical substance known as (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one, with the CAS number 1032754-93-0, is a complex organic compound characterized by its multi-cyclic structure and various functional groups. It features a thieno[3,2-d]pyrimidine core, which is known for its biological activity, particularly in medicinal chemistry. The presence of a piperazine ring contributes to its potential pharmacological properties, while the amino and hydroxyl groups may enhance its solubility and reactivity. This compound is likely to exhibit specific stereochemistry, as indicated by the (S) configuration, which can influence its interaction with biological targets. Such compounds are often investigated for their potential therapeutic applications, including roles in treating various diseases. Overall, the intricate structure of this substance suggests a significant potential for bioactivity, warranting further research into its properties and applications in drug development.

Formula: C₂₃H₃₀N₈O₃S

InChI: InChI=1S/C23H30N8O3S/c1-14-17(13-29-3-5-31(6-4-29)22(33)15(2)32)35-19-18(14)27-20(16-11-25-23(24)26-12-16)28-21(19)30-7-9-34-10-8-30/h11-12,15,32H,3-10,13H2,1-2H3,(H2,24,25,26)/t15-/m0/s1

SMILES: Cc1c(CN2CCN(CC2)C(=O)[C@H](C)O)sc2c1nc(c1c[nH]c(=N)nc1)nc2N1CCOCC1

Synonyms:

• Gdc-0980
• Gne 390
• (S)-1-(4-((2-(2-aMinopyriMidin-5-yl)-7-Methyl-4-Morpholinothieno[3,2-d]pyriMidin-6-yl)Methyl)piperazin-1-yl)-2-hydroxypropan-1-one
• Gdc-0980 (Rg7422)
• Apitolisib
• (2S)-1-(4-{[2-(2-Amino-5-pyrimidinyl)-7-methyl-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl}-1-piperazinyl)-2-hydroxy-1-propanone

Apitolisib

CAS: 1032754-93-0

Formula: C₂₃H₃₀N₈O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 498.6011

Ref: IN-DA0035ZH

Apitolisib

CAS: 1032754-93-0

Apitolisib

Purity: ≥98%

Molecular weight: 498.6g/mol

Ref: 54-BUP09690

Apitolisib

CAS: 1032754-93-0

Apitolisib (RG 7422) is a PI3K inhibitor, used in cancer trials, targeting PI3Kα, β, δ, γ (IC50= 5, 27, 7, 14 nM).

Formula: C₂₃H₃₀N₈O₃S

Purity: 98.28% - 99.64%

Color and Shape: Solid

Molecular weight: 498.6

Ref: TM-T1916

RG7422

CAS: 1032754-93-0

Ref: 7W-GW1302

GDC-0980

Controlled Product

CAS: 1032754-93-0

Applications GDC-0980 is used in the synthesis of PI3K inhibitors to treat carcinomas. Potent PI3K/mTOR dual Inhibitor.
References Sampath, D. et al.: Neoplasoa, 15, 694 (2013); Serova, M. et al.: Canc. Chemother. Pharm., 71, 1297 (2013);

Formula: C₂₃H₃₀N₈O₃S

Color and Shape: Neat

Molecular weight: 498.6

Ref: TR-G303000