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CAS 1032900-25-6

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Ceritinib

Description:
Ceritinib is a targeted therapy medication primarily used in the treatment of non-small cell lung cancer (NSCLC) that is characterized by anaplastic lymphoma kinase (ALK) gene rearrangements. It is classified as a kinase inhibitor, specifically designed to inhibit ALK and other related kinases, thereby disrupting cancer cell proliferation and survival. Ceritinib is administered orally and is known for its ability to penetrate the blood-brain barrier, making it effective against central nervous system metastases. The substance has a molecular formula that reflects its complex structure, which includes multiple functional groups that contribute to its pharmacological activity. Common side effects associated with ceritinib include gastrointestinal disturbances, liver enzyme elevations, and fatigue. Due to its mechanism of action, ceritinib is often considered for patients who have progressed on other ALK inhibitors, highlighting its role in personalized cancer therapy. As with any medication, monitoring for adverse effects and drug interactions is essential during treatment.
Formula:C28H36ClN5O3S
InChI:InChI=1S/C28H36ClN5O3S/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4/h6-9,14-18,20,30H,10-13H2,1-5H3,(H2,31,32,33,34)
InChI key:InChIKey=VERWOWGGCGHDQE-UHFFFAOYSA-N
SMILES:N(C1=C(OC(C)C)C=C(C(C)=C1)C2CCNCC2)C=3N=C(NC4=C(S(C(C)C)(=O)=O)C=CC=C4)C(Cl)=CN3
Synonyms:
  • 2,4-Pyrimidinediamine, 5-chloro-N<sup>4</sup>-[2-[(1-methylethyl)sulfonyl]phenyl]-N<sup>2</sup>-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-
  • 5-Chloro-N4-(2-((1-Methylethyl)Sulfonyl)Phenyl)-N2-(5-Methyl-2-(1-Methylethoxy)-4-(4-Piperidinyl)Phenyl)-2,4-Pyrimidinediamine
  • 5-Chloro-N<sup>4</sup>-[2-[(1-methylethyl)sulfonyl]phenyl]-N<sup>2</sup>-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine
  • Ldk 378
  • Ldk378
  • Zykadia
  • Ceritinib
  • 2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-
Found 13 products.