CAS 103300-74-9
:Taltirelin
Description:
Taltirelin, with the CAS number 103300-74-9, is a synthetic peptide that acts as a thyrotropin-releasing hormone (TRH) analog. It is primarily characterized by its ability to stimulate the release of thyroid-stimulating hormone (TSH) from the pituitary gland, thereby influencing thyroid function. Taltirelin is often studied for its potential therapeutic applications in conditions related to thyroid dysfunction and neurodegenerative diseases. The substance is typically administered via injection and has been investigated for its neuroprotective properties, particularly in models of Alzheimer's disease and other cognitive disorders. Its mechanism of action involves binding to TRH receptors, leading to a cascade of biological effects that promote neuronal health and function. Taltirelin is also noted for its relatively low toxicity profile, making it a candidate for further research in both endocrinology and neurology. As with any pharmaceutical compound, its use should be guided by clinical evidence and regulatory approval.
Formula:C17H23N7O5
InChI:InChI=1S/C17H23N7O5/c1-23-13(25)6-10(22-17(23)29)15(27)21-11(5-9-7-19-8-20-9)16(28)24-4-2-3-12(24)14(18)26/h7-8,10-12H,2-6H2,1H3,(H2,18,26)(H,19,20)(H,21,27)(H,22,29)/t10-,11-,12-/m0/s1
InChI key:InChIKey=LQZAIAZUDWIVPM-SRVKXCTJSA-N
SMILES:C([C@H](CC1=CN=CN1)NC(=O)[C@@H]2CC(=O)N(C)C(=O)N2)(=O)N3[C@H](C(N)=O)CCC3
Synonyms:- (4S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinecarbonyl-<span class="text-smallcaps">L</smallcap>-histidyl-<smallcap>L</span>-prolinamide
- (4S)-N-[(2S)-1-[(2S)-2-Carbamoylpyrrolidin-1-yl]-3-(3H-imidazol-4-yl)-1-oxopropan-2-yl]-1-methyl-2,6-dioxo-1,3-diazinane-4-carboxamide
- 2,6-dioxo-4-pyrimidinecarbonyl-L-histidyl-
- <span class="text-smallcaps">L</smallcap>-Prolinamide, (4S)-hexahydro-1-methyl-2,6-dioxo-4-pyrimidinecarbonyl-<smallcap>L</span>-histidyl-
- <span class="text-smallcaps">L</smallcap>-Prolinamide, N-[(hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl)carbonyl]-<smallcap>L</span>-histidyl-, (S)-
- Ceredist
- L-Prolinamide, N-[(hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl)carbonyl]-L-histidyl-, (S)-
- L-Prolinamide, N-[[(4S)-hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl]carbonyl]-L-histidyl- (9CI)
- L-Prolinamide,(4S)-hexahydro-1-methyl-
- N-{[(4S)-1-methyl-2,6-dioxohexahydropyrimidin-4-yl]carbonyl}-L-histidyl-L-prolinamide
- Ta 0910
- (4S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinecarbonyl-L-histidyl-L-prolinamide
- Taltirelin
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Found 8 products.
(4S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinecarbonyl-L-histidyl-L-prolinamide
CAS:Formula:C17H23N7O5Purity:98%Molecular weight:405.4084Taltirelin
CAS:Formula:C17H23N7O5·C2H4O2Color and Shape:White To Off-White SolidMolecular weight:405.42Taltirelin
CAS:<p>Taltirelin (TA-0910) is at thyrotropin-releasing hormone receptor (TRH-R) superagonist (IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in</p>Formula:C17H23N7O5Purity:98%Color and Shape:SolidMolecular weight:405.41Taltirelin Acetate
CAS:Formula:C17H23N7O5Purity:95%~99%Color and Shape:White to Off-white PowderMolecular weight:405.41Taltirelin Trifluoroacetic Acid Salt
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Analog of thyrotropin releasing hormone TRH, with pronounced CNS activity. Used in the treatment of spinocerebellar degeneration.<br>References Yamamura, M., et al.: Jpn. J. Pharmacol., 53, 451 (1990), Iwasaki, Y., et al.: Neurol. Res., 19, 613 (1997), Kinoshita, K., et al.: CNS Drug Rev., 4, 25 (1998), Morikawa, S., et al.: J. Pharm. Biomed. Anal., 16, 1267 (1998),<br></p>Formula:C19H24F3N7O7Color and Shape:NeatMolecular weight:519.43
