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CAS 1033805-28-5

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Telotristat

Description:
Telotristat is a synthetic small molecule primarily used in the treatment of carcinoid syndrome, particularly to manage diarrhea associated with this condition. It functions as a tryptophan hydroxylase inhibitor, which reduces serotonin production in the body, thereby alleviating symptoms related to excessive serotonin levels. Telotristat is characterized by its specific chemical structure, which includes a unique arrangement of atoms that contributes to its pharmacological activity. The substance is typically administered orally and is known for its relatively favorable safety profile, although it may cause side effects such as nausea, headache, and constipation. Its efficacy in reducing bowel movement frequency has been demonstrated in clinical trials, making it a valuable therapeutic option for patients suffering from carcinoid syndrome. As with any medication, it is essential for patients to consult healthcare professionals for personalized advice and monitoring during treatment.
Formula:C25H22ClF3N6O3
InChI:InChI=1S/C25H22ClF3N6O3/c1-13-8-9-35(34-13)20-11-16(26)6-7-17(20)22(25(27,28)29)38-21-12-19(32-24(31)33-21)15-4-2-14(3-5-15)10-18(30)23(36)37/h2-9,11-12,18,22H,10,30H2,1H3,(H,36,37)(H2,31,32,33)/t18-,22+/m0/s1
InChI key:NCLGDOBQAWBXRA-PGRDOPGGSA-N
SMILES:CC1=NN(C=C1)C2=C(C=CC(=C2)Cl)[C@H](C(F)(F)F)OC3=NC(=NC(=C3)C4=CC=C(C=C4)C[C@@H](C(=O)O)N)N
Synonyms:
  • (S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid
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