CAS 1038395-65-1

(E)-(4-(2-(1H-Indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone hydrochloride

CAS: 1038395-65-1

Formula: C₂₆H₃₁Cl₂N₃O₃

Purity: 96%

Molecular weight: 504.4486

Ref: IN-DA008TH7

Tirbanibulin dihydrochloride

CAS: 1038395-65-1

Tirbanibulin is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).

Formula: C₂₆H₃₁Cl₂N₃O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 504.45

Ref: TM-T15674

KX2-391 dihydrochloride

CAS: 1038395-65-1

KX2-391 is a peptide inhibitor of the protein tyrosine phosphatases PTP1B and SHP-2. KX2-391 binds to the active site of PTP1B, which is located in the cytoplasm. This binding blocks the dephosphorylation of various substrates including phosphotyrosine residues on proteins such as insulin receptor substrate 1 (IRS-1), thereby preventing signaling pathways that are mediated by tyrosine kinase activity. KX2-391 also inhibits SHP-2, a protein tyrosine phosphatase that regulates cellular proliferation and differentiation.
KX2-391 has been shown to activate protein kinase C (PKC) and cAMP response element binding protein (CREB). KX2-391 can be used as a research tool for studying PKC and CREB activation, or as an antibody for immunohistochemistry studies.

Formula: C₂₀H₂₀N₄O·HCl

Purity: Min. 95%

Molecular weight: 368.86 g/mol

Ref: 3D-NRB39565