CAS 1038915-73-9

niraparib p-toluenesulfonate

Description:

Niraparib p-toluenesulfonate is a chemical compound that serves as a salt form of niraparib, a potent inhibitor of poly(ADP-ribose) polymerase (PARP), which is primarily used in cancer therapy, particularly for ovarian cancer. The p-toluenesulfonate moiety enhances the solubility and stability of niraparib, facilitating its formulation for pharmaceutical applications. Niraparib itself is characterized by its ability to interfere with DNA repair mechanisms in cancer cells, leading to increased cell death, especially in tumors with BRCA mutations. The compound typically exhibits good oral bioavailability and is administered in a tablet form. Its pharmacokinetics include a relatively long half-life, allowing for once-daily dosing. Niraparib p-toluenesulfonate is also associated with a range of potential side effects, including hematological toxicities, which necessitate monitoring during treatment. Overall, this compound exemplifies the strategic design of drug formulations to enhance therapeutic efficacy while minimizing adverse effects in oncology.

Formula: C₂₆H₂₈N₄O₄S

InChI: InChI=1S/C19H20N4O.C7H8O3S/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14;1-6-2-4-7(5-3-6)11(8,9)10/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24);2-5H,1H3,(H,8,9,10)/t14-;/m1./s1

InChI key: LCPFHXWLJMNKNC-PFEQFJNWSA-N

SMILES: CC1=CC=C(C=C1)S(=O)(=O)O.C1C[C@H](CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N

Synonyms:

• (3S)-3-[4-[7-(Aminocarbonyl)-2H-indazol-2-yl]phenyl]piperidine tosylate
• Niraparib TOS
• Niraparib TsOH
• Niraparib Tosylate
• Niraparib(MK-4827) tosylate
• MK-4827 (tosylate)
• MK-4827, Niraparib TsOH salt
• MK-4827(Niraparib) tosylate
• NIRAPARIB TOSYLATE;MK 4827 TOSYLATE;MK4827 TOSYLATE
• MK-4827 (tosylate) ISO 9001：2015 REACH
• 2H-Indazole-7-carboxamide,2-[4-[(3S)-3-piperidinyl]phenyl]-,4-methylbenzenesulfonate(1:1)

MK-4827 (tosylate)

CAS: 1038915-73-9

Formula: C₂₆H₂₈N₄O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 492.5899

Ref: IN-DA008TI4

Niraparib tosylate

CAS: 1038915-73-9

Niraparib tosylate

Formula: C₁₉H₂₀N₄O·C₇H₈O₃S

Purity: ≥98%

Molecular weight: 492.59

Ref: 54-BUP09894

Niraparib Tosylate

CAS: 1038915-73-9

Applications Niraparib is a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.
References Jones, P., et al.: J. Med. Chem., 52, 7170 (2009); Giannini, G., et al.: Bioorg. Med. Chem. Lett., 24, 462 (2014)

Formula: C₁₉H₂₀N₄O·C₇H₈O₃S

Color and Shape: Neat

Molecular weight: 492.6

Ref: TR-N481405

Niraparib tosylate

CAS: 1038915-73-9

Niraparib tosylate (MK-4827 (tosylate))(with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor.

Formula: C₁₉H₂₀N₄O·C₇H₈O₃S

Purity: 98.19% - 99.34%

Color and Shape: Solid

Molecular weight: 492.59

Ref: TM-T6892

MK-4827 tosylate

CAS: 1038915-73-9

Ref: 7W-GW7013

Niraparib Tosylate

CAS: 1038915-73-9

Niraparib Tosylate is a hydrogen bond inhibitor that prevents the formation of hydrogen bonds between purine bases in DNA. This agent is used to treat cancer by inhibiting tumor cell proliferation. It also inhibits cellular and sequestered sulfonic acids, which are important for the immune response. Niraparib Tosylate has shown anti-inflammatory properties by inhibiting lymphocyte activation and preventing chemotherapy-induced neutropenia. This drug also targets microenvironment factors, such as homologous recombination repair, that lead to cancer progression.

Formula: C₁₉H₂₀N₄O·C₇H₈O₃S

Purity: Min. 95%

Molecular weight: 320.39 g/mol

Ref: 3D-NRB91573