CAS 10416-59-8

N,O-Bis(trimethylsilyl)acetamide

Description:

N,O-Bis(trimethylsilyl)acetamide, commonly referred to as BSA, is a chemical compound characterized by its use as a derivatizing agent in analytical chemistry, particularly in gas chromatography and mass spectrometry. It features a structure that includes two trimethylsilyl groups attached to the nitrogen and oxygen atoms of an acetamide moiety, enhancing its ability to form stable derivatives with polar functional groups. This compound is typically a colorless to pale yellow liquid with a relatively low boiling point, making it suitable for various applications in organic synthesis and sample preparation. BSA is known for its ability to improve the volatility and thermal stability of analytes, facilitating their detection and quantification. Additionally, it is relatively stable under standard laboratory conditions but should be handled with care due to its reactivity with moisture and potential to release trimethylsilanol upon hydrolysis. Overall, N,O-Bis(trimethylsilyl)acetamide is a valuable tool in the field of analytical chemistry for enhancing the analysis of complex mixtures.

Formula: C₈H₂₁NOSi₂

InChI: InChI=1S/C8H21NOSi2/c1-8(9-11(2,3)4)10-12(5,6)7/h1-7H3

InChI key: InChIKey=SIOVKLKJSOKLIF-UHFFFAOYSA-N

SMILES: N([Si](C)(C)C)=C(O[Si](C)(C)C)C

Synonyms:

• Acetimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester
• BSA
• Bis trimethyl silyl acetamide
• Bis(trimethylsilyl)acetamide
• Bis(trimethylsilyl)acetimidate
• Dynasylan Bsa
• Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester
• Ls 7270
• N,O-BIS-(Trimethyl silyl)-acetamide
• N,O-Bis(trimethylsilyl)aectamide
• N,O-Bis-trimethylsilylacetoamide
• N,O-Di(trimethylsilyl)acetamide
• N-(Trimethylsilyl)acetimidic acid trimethylsilyl ester
• N-(Trimethylsilyl)ethanimidic acid trimethylsilyl ester
• NO-Bis (trimethylsilyl) acetamide
• O,N-Bis(trimethylsilyl)acetamide
• trimethylsilyl (1E)-N-(trimethylsilyl)ethanimidoate
• trimethylsilyl N-(trimethylsilyl)ethanimidoate
• trimethylsilyl N-trimethylsilylacetamidate

N,O-Bis(trimethylsilyl)acetamide [Trimethylsilylating Agent]

CAS: 10416-59-8

Formula: C₈H₂₁NOSi₂

Purity: >80.0%(GC)

Color and Shape: Colorless to Light yellow clear liquid

Molecular weight: 203.43

Ref: 3B-B0511

N,O-Bis(trimethylsilyl)acetamide (25% in Acetonitrile) [Trimethylsilylating Reagent, for NH2 compounds]

CAS: 10416-59-8

Color and Shape: Colorless to Light yellow clear liquid

Ref: 3B-B0510

N,O-Bis(trimethylsilyl)acetamide Kit BSA 1 mL × 8 / Reaction vial, capacity 2 mL × 8

CAS: 10416-59-8

Purity: >80.0%(GC)

Color and Shape: Colorless to Light yellow clear liquid

Ref: 3B-B0911

BSA [=N,O-Bis(trimethylsilyl)acetamide] [for Gas Chromatography]

CAS: 10416-59-8

Formula: C₈H₂₁NOSi₂

Purity: >80.0%(GC)

Color and Shape: Colorless to Light yellow clear liquid

Molecular weight: 203.43

Ref: 3B-A5601

TMS-BA [=N,O-Bis(trimethylsilyl)acetamide] (25% in Acetonitrile) [for Gas Chromatography]

CAS: 10416-59-8

Purity: No impurity higher than Isopropyl myristate(50 ppm) after 5 min + hold up time

Color and Shape: Colorless to Light yellow clear liquid

Ref: 3B-A5602

N,O-Bis(trimethylsilyl)acetamide, 95%

CAS: 10416-59-8

N,O-Bis(trimethylsilyl)acetamide is used as a regioselective desulfation reagent as well as a preparatory agent for carbohydrate and alcohol trimethylsilyl ethers. It is also used for the derivatization of polar functional groups such as carboxylic acids, phenols, steroids, amines, alcohols, alkaloi

Formula: C₈H₂₁NOSi₂

Purity: 95%

Color and Shape: Clear, colorless to pale yellow, Liquid

Molecular weight: 203.43

Ref: 02-L00183

N,O-Bis(Trimethylsilyl)Acetamide

CAS: 10416-59-8

Formula: C₈H₂₁NOSi₂

Purity: 95%

Color and Shape: Liquid

Molecular weight: 203.4294

Ref: IN-DA00399B

N,O-Bis(trimethylsilyl)acetamide

CAS: 10416-59-8

Formula: C₈H₂₁NOSi₂

Purity: (GC) ≥ 94.0%

Color and Shape: Clear, colourless to light yellow liquid

Molecular weight: 203.43

Ref: 7W-GK3085

Trimethylsilyl N-(trimethylsilyl)acetimidate

CAS: 10416-59-8

Trimethylsilyl N-(trimethylsilyl)acetimidate

Formula: C₈H₂₁NOSi₂

Purity: 97%

Color and Shape: clear. almost colourless liquid

Molecular weight: 203.42943g/mol

Ref: 54-OR5155A

N,O-Bis(trimethylsilyl)acetamide Kit TMS-BA (25% in Acetonitrile) 1 mL × 8 / Reaction vial, capacity 2 mL × 8 [Trimethylsilylating Reagent, for NH2 compounds]

CAS: 10416-59-8

Color and Shape: Colorless to Light yellow clear liquid

Ref: 3B-T0691

N,O-Bis(trimethylsilyl)acetamide (BSA)

CAS: 10416-59-8

S02375 - N,O-Bis(trimethylsilyl)acetamide (BSA)

Formula: C₈H₂₁NOSi₂

Purity: >97%

Color and Shape: Clear

Molecular weight: 203.432

Ref: 10-S02375

N,O-Bis(trimethylsilyl) Acetamide

CAS: 10416-59-8

Formula: C₈H₂₁NOSi₂

Molecular weight: 203.43

Ref: 4Z-A-133025

N,O-Bis(trimethylsilyl)acetamide

Controlled Product

CAS: 10416-59-8

Applications N,O-Bis(trimethylsilyl)acetamide is used as a reagent in the synthesis of 4'-spirocyclic phosphono-nucleosides as potential inhibitors of hepatitis C virus NS5B polymerase. Also used as a reagent in the microwave-assisted synthesis of purine nucleosides as selective cholinesterase inhibitors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Dang, Q., et al.: Tetrahedron Lett., 55, 4407 (2014); Schwarz, S., et al.: Org. Biomol. Chem., 12, 2446 (2014)

Formula: C₈H₂₁NOSi₂

Color and Shape: Neat

Molecular weight: 203.43

Ref: TR-B588675

N,O-Bis(trimethylsilyl) acetamide

CAS: 10416-59-8

N,O-Bis(trimethylsilyl) acetamide is a protein that is used as a reagent for the detection of integrin receptors. It can be used to identify human immunoglobulin and human serum proteins. This compound has been shown to be pluripotent in cells, which means that it can differentiate into any type of cell. N,O-Bis(trimethylsilyl) acetamide has been shown to have surfactant properties and can be used as an alternative in toxicity studies. This compound has been shown to be toxic to bowel disease cells when tested with a dose of 3mg/mL. The disulfide bond within this molecule may be important for its biological activity. Synchronous fluorescence spectroscopy and plasma mass spectrometry are two methods that have been used to study the structure of this molecule. Electrochemical impedance spectroscopy is another method that has been used in the structural analysis of this molecule.

Formula: C₈H₂₁NOSi₂

Purity: Min. 95 Area-%

Color and Shape: Colorless Yellow Clear Liquid

Molecular weight: 203.43 g/mol

Ref: 3D-FB03098

N,O-BIS(TRIMETHYLSILYL)ACETAMIDE

CAS: 10416-59-8

Trimethylsilyl Blocking Agent
Used as a protecting group for reactive hydrogens in alcohols, amines, thiols, and carboxylic acids. Organosilanes are hydrogen-like, can be introduced in high yield, and can be removed under selective conditions. They are stable over a wide range of reaction conditions and can be removed in the presence of other functional groups, including other protecting groups. The tolerance of silylated alcohols to chemical transformations summary is presented in Table 1 of the Silicon-Based Blocking Agents brochure.
Alkyl Silane - Conventional Surface Bonding
Aliphatic, fluorinated aliphatic or substituted aromatic hydrocarbon substituents are the hydrophobic entities which enable silanes to induce surface hydrophobicity. The organic substitution of the silane must be non-polar. The hydrophobic effect of the organic substitution can be related to the free energy of transfer of hydrocarbon molecules from an aqueous phase to a homogeneous hydrocarbon phase. A successful hydrophobic coating must eliminate or mitigate hydrogen bonding and shield polar surfaces from interaction with water by creating a non-polar interphase. Although silane and silicone derived coatings are in general the most hydrophobic, they maintain a high degree of permeability to water vapor. This allows coatings to breathe and reduce deterioration at the coating interface associated with entrapped water. Since ions are not transported through non-polar silane and silicone coatings, they offer protection to composite structures ranging from pigmented coatings to rebar reinforced concrete. A selection guide for hydrophobic silanes can be found on pages 22-31 of the Hydrophobicity, Hydrophilicity and Silane Surface Modification brochure.
Bis(Trimethylsilyl)acetamide; N,O-Bis(trimethylsilyl)acetamide; Trimethylsilyl-N-Trimethylsilylacetamidate; BSA
More reactive than SIH6110.0Releases neutral acetamide upon reactionBoth silyl groups usedUsed for silylation in analytical applicationsReactions catalyzed by acidForms enol silyl ethers in ionic liquidsNafion SAC-13 has been shown to be a recyclable catalyst for the trimethylsilylation of primary, secondary, and tertiary alcohols in excellent yields and short reaction timesSummary of selective deprotection conditions is provided in Table 7 through Table 20 of the Silicon-Based Blocking Agents brochure

Formula: C₈H₂₁NOSi₂

Purity: 95%

Color and Shape: Straw Liquid

Molecular weight: 203.43

Ref: 3H-SIB1846.0

N,O-Bis-(Trimethylsilyl) Acetamide (BSA) extrapure, 95%

CAS: 10416-59-8

Formula: C₈H₂₁NOSi₂

Purity: min. 95.0%

Color and Shape: Clear, Colourless to pale yellow, Liquid

Molecular weight: 203.43

Ref: SR-26477