CAS 104375-88-4

5'-O-(DIMETHOXYTRITYL)-5-IODO-2'-DEOXYURIDINE

Description:

5'-O-(Dimethoxytrityl)-5-iodo-2'-deoxyuridine is a modified nucleoside that plays a significant role in nucleic acid chemistry, particularly in the synthesis of oligonucleotides. This compound features a deoxyuridine base, which is a nucleoside composed of a pyrimidine base (uridine) linked to a deoxyribose sugar. The presence of the dimethoxytrityl (DMT) protecting group at the 5' position enhances the stability and solubility of the molecule, making it suitable for use in solid-phase synthesis of DNA. The iodine substitution at the 5' position introduces a halogen that can be utilized for further chemical modifications or reactions, such as coupling with other nucleotides. This compound is typically used in research and pharmaceutical applications, particularly in the development of antisense oligonucleotides and other nucleic acid-based therapeutics. Its unique structural features contribute to its utility in various biochemical applications, including gene therapy and molecular diagnostics.

Formula: C₃₀H₂₉IN₂O₇

Synonyms:

• 5'-O-DMTr-5-Iodo-2'-deoxyuridine

2'-Deoxy-5'-O-DMT-5-iodouridine

CAS: 104375-88-4

Formula: C₃₀H₂₉IN₂O₇

Purity: 97%

Color and Shape: Solid

Molecular weight: 656.4649

Ref: IN-DA00861D

1-((2R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione

CAS: 104375-88-4

1-((2R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione

Formula: C₃₀H₂₉IN₂O₇

Purity: 97%

Molecular weight: 656.47

Ref: 54-OR1074528

2''-Deoxy-5''-O-DMT-5-iodouridine

CAS: 104375-88-4

Ref: 7W-GN9294

5'-O-DMTr-5-Iodo-2'-deoxyuridine

CAS: 104375-88-4

5'-O-DMTr-5-Iodo-2'-deoxyuridine is a Halo-nucleoside.

Formula: C₃₀H₂₉IN₂O₇

Color and Shape: Solid

Molecular weight: 656.46

Ref: TM-TNU0647

2'-Deoxy-5'-O-DMT-5-iodouridine

CAS: 104375-88-4

2'-Deoxy-5'-O-DMT-5-iodouridine is an intercalating agent that binds to DNA and RNA. It can be used as a probe for the detection of specific sequences in human cells. The fluorophore attached to the molecule allows it to be detected by fluorescence microscopy, while the chromophore is responsible for its ability to emit light at a wavelength of 535 nm. 2'-Deoxy-5'-O-DMT-5-iodouridine has been shown to enhance nucleotide excision repair and increase the sensitivity of cancer cells to chemotherapy drugs such as cisplatin. The molecule can also be used as a fluorescent protein marker in her-2 gene amplification and overexpression studies.

Formula: C₃₀H₂₉IN₂O₇

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 656.48 g/mol

Ref: 3D-ND08238

5’-O-DMTr-5-iodo-2’-deoxyuridine

CAS: 104375-88-4

1-((2R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione

Formula: C₃₀H₂₉IN₂O₇

Purity: 97%

Molecular weight: 656.46

Ref: IN-DG105150