CAS 104632-26-0

Pramipexole

Description:

Pramipexole is a medication primarily used in the treatment of Parkinson's disease and restless legs syndrome. It functions as a dopamine agonist, specifically targeting D2 and D3 dopamine receptors in the brain, which helps to alleviate symptoms associated with these conditions. The chemical formula of pramipexole is C10H13N3S, and it has a molecular weight of approximately 209.3 g/mol. This compound is typically administered orally and is known for its relatively high bioavailability. Pramipexole is characterized by its ability to cross the blood-brain barrier, allowing it to exert its therapeutic effects directly within the central nervous system. It is generally well-tolerated, though side effects can include nausea, dizziness, and somnolence. The substance is classified as a prescription medication and is subject to regulation in many countries. Its pharmacokinetics involve renal excretion, making dosage adjustments necessary in patients with impaired kidney function. Overall, pramipexole represents an important therapeutic option for managing dopamine-related disorders.

Formula: C₁₀H₁₇N₃S

InChI: InChI=1/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m1/s1

InChI key: InChIKey=FASDKYOPVNHBLU-ZETCQYMHSA-N

SMILES: NC1=NC2=C(C[C@@H](NCCC)CC2)S1

Synonyms:

• (6S)-4,5,6,7-Tetrahydro-N⁶-propyl-2,6-benzothiazolediamine
• (6S)-6-N-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
• (6S)-N6-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
• (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole
• (S)-2-Amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole
• (S)-2-Amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole
• (S)-Pramipexole
• 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N(sup 6)-propyl-, (S)-
• 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, (S)-
• 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N⁶-propyl-, (6S)-
• 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N⁶-propyl-, (S)-
• 6-Propylamino-4,5,6,7-tetrahydro-1,3-benzothiazole-2-amine
• Mirapexin
• Oprymea
• Pramipexol
• Pramipexol [Spanish]
• Pramipexole Teva
• Pramipexole [USAN:INN]
• Pramipexolum
• Pramipexolum [Latin]
• Sifrol
• Snd 919
• Sud 919Cl2Y
• Sud919Cl2Y
• U-98528E
• Unii-83619Peu5T
• 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, (6S)-
• Pramipexole
• (6S)-4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine
• Pramipexol diclorohidrato monohidrato
• (S)-2-Amino-6-(propylamino)-4,5,6,7-tetrahydrobenzothiazoltetrahydrobenzothiazol
• n'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine
• (6S)-N'-Propyl-4,5,6,7-tetrahydrobenzothiazole-2,6α-diamine
• PRAMIPEXOLE: PRAMIPEXOLE DIHYDROCHLORIDE
• (S)-6-(Propylamino)-4,5,6,7-tetrahydrobenzothiazole-2-amine
• (S)-4,5,6,7-Tetrahydro-N'-propylbenzothiazole-2,6-diamine
• PRAMIPEXOLE 2HCL MONOHYDRATE
• (6S)-4,5,6,7-Tetrahydro-2-amino-6α-(propylamino)benzothiazole

Pramipexole

CAS: 104632-26-0

Pramipexole (SND 919), a dopamine agonist for Parkinson's, may cause mild, temporary enzyme spikes, not acute liver injury.

Formula: C₁₀H₁₇N₃S

Purity: 98% - 99.96%

Color and Shape: Solid

Molecular weight: 211.327

Ref: TM-T1476

(S)-N6-Propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine

CAS: 104632-26-0

(S)-N6-Propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine

Formula: C₁₀H₁₇N₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 211.32708

Ref: 54-OR350364

Pramipexole

CAS: 104632-26-0

Pramipexole

Formula: C₁₀H₁₇N₃S

Purity: 99.5%

Molecular weight: 211.33

Ref: 54-BUP18063

Pramipexole

CAS: 104632-26-0

Formula: C₁₀H₁₇N₃S

Purity: (HPLC) ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 211.33

Ref: 7W-GP9419

Pramipexole

CAS: 104632-26-0

Formula: C₁₀H₁₇N₃S

Color and Shape: Neat

Molecular weight: 211.33

Ref: 86-MM0332.00

(6S)-4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine

CAS: 104632-26-0

Formula: C₁₀H₁₇N₃S

Purity: 97%

Color and Shape: Solid

Molecular weight: 211.3271

Ref: IN-DA003CNR

(S)-Pramipexole

Controlled Product

CAS: 104632-26-0

Applications (S)-Pramipexole enantiomer. A dopamine-D2-receptor agonist. Antiparkinsonian. Pramipexole (Mirapex, Mirapexin, Sifrol) is a non-ergoline dopamine agonist indicated for treating early-stage Parkinson's disease (PD) and restless legs syndrome (RLS).[1] It is also sometimes used off-label as a treatment for cluster headache and to counteract the problems with sexual dysfunction experienced by some users of the selective serotonin reuptake inhibitor (SSRI) antidepressants.
References Mierau, J., et al.: J. Med. Chem., 30, 494 (1987), Schilling, J.C., et al.: Clin. Pharmacol. Ther., 51, 541 (1992), Kieburtz, K., et al.: J. Am. Med. Assoc., 278, 125 (1997)

Formula: C₁₀H₁₇N₃S

Color and Shape: Neat

Molecular weight: 211.33

Ref: TR-P700750

(S)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine

CAS: 104632-26-0

Formula: C₁₀H₁₇N₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 211.33

Ref: 10-F225637

Pramipexole

Controlled Product

CAS: 104632-26-0

Dopamine (D2 and D3) receptor agonist; has anti-parkinsonian effects

Formula: C₁₀H₁₇N₃S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 211.33 g/mol

Ref: 3D-FP45322

Pramipexole

CAS: 104632-26-0

Formula: C₁₀H₁₇N₃S

Molecular weight: 211.33

Ref: ST-EA-CP-P21000