CAS 104713-75-9

Barnidipine

Description:

Barnidipine is a calcium channel blocker primarily used in the treatment of hypertension. It belongs to the dihydropyridine class of calcium antagonists, which work by inhibiting the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac tissue. This action leads to vasodilation, reducing peripheral resistance and lowering blood pressure. Barnidipine is characterized by its long half-life, allowing for once-daily dosing, which enhances patient compliance. The compound exhibits selectivity for vascular smooth muscle over cardiac tissue, minimizing potential side effects such as reflex tachycardia. Additionally, it has been noted for its favorable pharmacokinetic profile, including good oral bioavailability. Barnidipine's efficacy in managing hypertension has been supported by clinical studies, and it is often considered in treatment regimens for patients with specific cardiovascular conditions. As with any medication, potential side effects may include dizziness, headache, and peripheral edema, necessitating careful monitoring during therapy.

Formula: C₂₇H₂₉N₃O₆

InChI: InChI=1S/C27H29N3O6/c1-17-23(26(31)35-3)25(20-10-7-11-21(14-20)30(33)34)24(18(2)28-17)27(32)36-22-12-13-29(16-22)15-19-8-5-4-6-9-19/h4-11,14,22,25,28H,12-13,15-16H2,1-3H3/t22-,25-/m0/s1

InChI key: InChIKey=VXMOONUMYLCFJD-DHLKQENFSA-N

SMILES: C(O[C@@H]1CN(CC2=CC=CC=C2)CC1)(=O)C=3[C@H](C(C(OC)=O)=C(C)NC3C)C4=CC(N(=O)=O)=CC=C4

Synonyms:

• (+)-(3'S,4S)-1-Benzyl-3-Pyrrolidinyl Methyl 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylate
• (3S)-1-benzylpyrrolidin-3-yl methyl (4S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• (3S)-1-benzylpyrrolidin-3-yl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-[(3S)-1-(phenylmethyl)-3-pyrrolidinyl] ester, (4S)-
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3S)-1-(phenylmethyl)-3-pyrrolidinyl ester, (4S)-
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-pyrrolidinyl ester, [S-(R*,R*)]-
• Hypoca
• Mepirodipine
• Barnidipine

Barnidipine

CAS: 104713-75-9

Formula: C₂₇H₂₉N₃O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 491.5357

Ref: IN-DA007XM1

Barnidipine

CAS: 104713-75-9

Barnidipine

Formula: C₂₇H₂₉N₃O₆

Purity: ≥98%

Molecular weight: 491.54

Ref: 54-BUP02543

Barnidipine

CAS: 104713-75-9

Formula: C₂₇H₂₉N₃O₆

Molecular weight: 491.54

Ref: 7W-GP4073

Barnidipine

CAS: 104713-75-9

Formula: C₂₇H₂₉N₃O₆

Molecular weight: 491.55

Ref: 4Z-B-414

Barnidipine

CAS: 104713-75-9

Barnidipine (YM-09730-5(Free base)) is a calcium channel blocker.

Formula: C₂₇H₂₉N₃O₆

Purity: 99.98%

Color and Shape: Solid

Molecular weight: 491.54

Ref: TM-T7550

Barnidipine

CAS: 104713-75-9

Formula: C₂₇H₂₉N₃O₆

Molecular weight: 491.54

Ref: ST-EA-CP-B70000