CAS 1047645-82-8

Formula: C18H18Cl3FN4OS

InChI: InChI=1S/C18H17Cl2FN4OS.ClH/c1-25-16(14(19)9-23-25)13-7-15(27-17(13)20)18(26)24-12(8-22)6-10-3-2-4-11(21)5-10;/h2-5,7,9,12H,6,8,22H2,1H3,(H,24,26);1H/t12-;/m0./s1

InChI key: YFQJOPFTGMHYNV-YDALLXLXSA-N

SMILES: CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)N[C@@H](CC3=CC(=CC=C3)F)CN)Cl.Cl

GSK2110183B

CAS: 1047645-82-8

Formula: C₁₈H₁₈Cl₃FN₄OS

Purity: %

Color and Shape: Solid

Molecular weight: 463.7841

Ref: IN-DA008TDB

Afuresertib hydrochloride

CAS: 1047645-82-8

Afuresertib hydrochloride

Formula: C₁₈H₁₈Cl₃FN₄OS

Purity: ≥98%

Molecular weight: 463.8

Ref: 54-BUP09723

Afuresertib hydrochloride

CAS: 1047645-82-8

Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)

Formula: C₁₈H₁₈Cl₃FN₄OS

Purity: 99.96%

Color and Shape: Solid

Molecular weight: 463.784

Ref: TM-T7885

Afuresertib HCl

CAS: 1047645-82-8

N-((S)-1-Amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxamide hydrochloride

Formula: C₁₈H₁₈Cl₃FN₄OS

Purity: 98+%

Molecular weight: 463.78

Ref: IN-DG300977

Afuresertib hydrochloride

CAS: 1047645-82-8

Purity: 98+%

Molecular weight: 462.025

Ref: 10-F857573

Afuresertib hydrochloride

CAS: 1047645-82-8

Afuresertib hydrochloride is a small-molecule inhibitor, which is synthesized as a targeted therapeutic agent. It is specifically designed to inhibit the activity of AKT kinase, a crucial component in the PI3K/AKT/mTOR signaling pathway. This pathway is frequently deregulated in various cancers, contributing to tumor growth, survival, and resistance to conventional therapies.

Formula: C₁₈H₁₈Cl₃FN₄OS

Purity: Min. 95%

Molecular weight: 463.78 g/mol

Ref: 3D-XRB64582