CAS: 104987-11-3 - Tacrolimus

Formula: C₄₄H₆₉NO₁₂

InChI: InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1

InChI key: InChIKey=QJJXYPPXXYFBGM-LFZNUXCKSA-N

SMILES: O=C1OC(C(=CC2CCC(O)C(OC)C2)C)C(C)C(O)CC(=O)C(C=C(C)CC(C)CC(OC)C3OC(O)(C(=O)C(=O)N4CCCCC14)C(C)CC3OC)CC=C

Synonyms:

• 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
• 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-
• FR 900506
• 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
• (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone

Tacrolimus Monohydrate

CAS: 104987-11-3109581-93-3

• Formula: C₄₄H₆₉NO₁₂·H₂O
• Purity: >80.0%(HPLC)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 822.05

(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone

CAS: 104987-11-3

• Formula: C₄₄H₆₉NO₁₂
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 804.0182

Tacrolimus

CAS: 104987-11-3

• Formula: C₄₄H₆₉NO₁₂
• Color and Shape: White To Off-White Solid
• Molecular weight: 804.03

Tacrolimus

CAS: 104987-11-3

• Formula: C₄₄H₆₉NO₁₂
• Purity: 95%~99%
• Molecular weight: 804.031

FK-506

CAS: 104987-11-3

• Formula: C₄₄H₆₉NO₁₂
• Purity: By hplc: 99.91% (Typical Value in Batch COA)
• Color and Shape: white powder
• Molecular weight: 804.02g/mol

Tacrolimus

CAS: 104987-11-3

Tacrolimus (Fujimycin) can bind FKBP12 to form a high-affinity complex (Ki: 0.2 nM) which inhibits …

• Formula: C₄₄H₆₉NO₁₂
• Purity: 98% - 99.94%
• Color and Shape: White Or Off-White Crystalline Powder
• Molecular weight: 804.02

Tacrolimus (FK506)

CAS: 104987-11-3

Applications An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of …

• Formula: C₄₄H₆₉NO₁₂
• Color and Shape: Neat
• Molecular weight: 804.02

Tacrolimus

CAS: 104987-11-3

Antirheumatic; immunosuppressant; neuroprotective; neuroregenerative

• Formula: C₄₄H₆₉NO₁₂
• Purity: Min. 98 Area-%
• Color and Shape: White Powder
• Molecular weight: 804.02 g/mol

Tacrolimus - Bio-X ™

CAS: 104987-11-3

Tacrolimus is a calcineurin inhibitor drug that is used for the prevention of rejection after …

• Formula: C₄₄H₆₉NO₁₂
• Purity: Min. 95%
• Color and Shape: White Off-White Powder
• Molecular weight: 804.02 g/mol

Everolimus, Cyclosporine and Tacrolimus Mix Standard

CAS: 104987-11-3159351-69-6 59865-13-3

• Formula: C₅₃H₈₃NO₁₄•C₆₂H₁₁₁N₁₁O₁₂•C₄₄H₆₉NO₁₂
• Color and Shape: Mixture

FK-506 (Tacrolimus)

CAS: 104987-11-3

FK-506 is an immunosuppressant that is produced by fermentation. It is used to prevent the …

• Formula: C₄₄H₆₉NO₁₂
• Purity: Min. 95%
• Molecular weight: 804 g/mol