CAS 159351-69-6

Everolimus

Description:

Everolimus is an immunosuppressant and an antineoplastic agent, primarily used in the treatment of various cancers and to prevent organ transplant rejection. It is a derivative of rapamycin and functions as a selective inhibitor of the mammalian target of rapamycin (mTOR), a key regulator of cell growth, proliferation, and survival. The chemical formula of everolimus is C53H83N1O14, and it has a molecular weight of approximately 958.2 g/mol. This compound is typically administered orally and is known for its relatively low solubility in water, which can affect its bioavailability. Everolimus exhibits a range of pharmacological effects, including anti-proliferative and anti-angiogenic properties, making it effective in treating certain types of tumors, such as renal cell carcinoma and neuroendocrine tumors. Additionally, it is used in the management of conditions like tuberous sclerosis complex. Due to its immunosuppressive effects, careful monitoring is required to manage potential side effects, including increased risk of infections and other complications.

Formula: C₅₃H₈₃NO₁₄

InChI: InChI=1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1

InChI key: InChIKey=HKVAMNSJSFKALM-GKUWKFKPSA-N

SMILES: O=C1N2[C@](C(=O)O[C@]([C@@H](C[C@H]3C[C@@H](OC)[C@H](OCCO)CC3)C)(CC(=O)[C@H](C)/C=C(\C)/[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(/C)\[C@@H](OC)C[C@]4(O[C@@](O)(C1=O)[C@H](C)CC4)[H])[H])(CCCC2)[H]

Synonyms:

• (3S,6R,7Z,9R,10R,12R,14S,15E,17Z,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-1-methylethyl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
• 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, rapamycin deriv.
• 40-O-(2-Hydroxyethyl)rapamycin
• 42-O-(2-Hydroxy)ethyl rapamycin
• 42-O-(2-Hydroxyethyl)-rapamycin
• Afinitor
• Afinitor Disperz
• Certica
• Certican
• Certican(R)
• RAD
• Rad-001
• Rapamycin, 42-O-(2-hydroxyethyl)-
• Sdz-Rad
• Sdzrad
• Votubia
• Xience
• Xience V

Everolimus

CAS: 159351-69-6

A rapamycin analog

Formula: C₅₃H₈₃NO₁₄

Color and Shape: Powder or crystals or crystalline powder or granules or amorphous solid, White to off-white to pale yellow

Molecular weight: 958.24

Ref: 02-J60139

EVEROLIMUS CRS

CAS: 159351-69-6

EVEROLIMUS CRS

Ref: 41-Y0002048

EVEROLIMUS FOR SYSTEM SUITABILITY A CRS

CAS: 159351-69-6

EVEROLIMUS FOR SYSTEM SUITABILITY A CRS

Ref: 41-Y0002354

Everolimus

CAS: 159351-69-6

Antibiotics nesoi

Formula: C₅₃H₈₃NO₁₄

Color and Shape: White Yellow Powder

Molecular weight: 957.58136

Ref: 45-1268976

Rapamycin, 42-O-(2-hydroxyethyl)-

CAS: 159351-69-6

Formula: C₅₃H₈₃NO₁₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 958.2244

Ref: IN-DA001QMG

Everolimus

CAS: 159351-69-6

Everolimus

Formula: C₅₃H₈₃NO₁₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 958.22

Ref: 54-OR1026213

Everolimus

CAS: 159351-69-6

(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-((R)-1-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)propan-2-yl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1]oxa[4]azacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentaone

Formula: C₅₃H₈₃NO₁₄

Purity: 98%

Molecular weight: 958.22

Ref: IN-DG41334

Everolimus

CAS: 159351-69-6

Everolimus

Formula: C₅₃H₈₃NO₁₄

Purity: ≥95%

Molecular weight: 958.22

Ref: 54-BUP15400

Everolimus

CAS: 159351-69-6

Formula: C₅₃H₈₃NO₁₄

Color and Shape: White To Off-White Solid

Molecular weight: 958.24

Ref: 4Z-E-101

Everolimus

CAS: 159351-69-6

Everolimus (SDZ-RAD) is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or in combination with calcineurin inhibitors.

Formula: C₅₃H₈₃NO₁₄

Purity: 97.76% - 99.78%

Color and Shape: Solid

Molecular weight: 958.22

Ref: TM-T1784

Everolimus

CAS: 159351-69-6

Formula: C₅₃H₈₃NO₁₄

Purity: ≥ 96.0%

Color and Shape: White to off-white solid

Molecular weight: 958.22

Ref: 7W-GP1203

Everolimus

Controlled Product

CAS: 159351-69-6

Impurity Everolimus EP Impurity C
Stability Hygroscopic
Applications Everolimus Macrolide immunosuppressant; Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation.
References Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001), Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001), Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002),

Formula: C₅₃H₈₃NO₁₄

Purity: ~90%

Color and Shape: Neat

Molecular weight: 958.22

Ref: TR-E945400

Everolimus

CAS: 159351-69-6

mTOR kinase inhibitor; rapamycin analog; immunosuppressant

Formula: C₅₃H₈₃NO₁₄

Purity: 90%

Color and Shape: White Off-White Powder

Molecular weight: 958.23 g/mol

Ref: 3D-FE23209

Everolimus

CAS: 159351-69-6

Formula: C₅₃H₈₃NO₁₄

Molecular weight: 958.2

Ref: ST-EA-CP-E33000

Everolimus, Cyclosporine and Tacrolimus Mix Standard

Controlled Product

CAS: 104987-11-3, 159351-69-6, 59865-13-3

Formula: MixtureVisitourWebsite

Color and Shape: Mixture

Molecular weight: Mixture - Visit our Website

Ref: TR-E608165