![N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,…](https://static.cymitquimica.com/cas-image/thumb-webp/319556-n-benzoyl-5-o-44-dimethoxytrityl-2-o-tert-butyl-dimethylsilyl-adenosine-3-2-cyanoethyl-n-n-diisopropyl-phosphoramidite.webp)
CAS 104992-55-4
:N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
Description:
N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite, with CAS number 104992-55-4, is a phosphoramidite derivative of adenosine, commonly used in the synthesis of oligonucleotides. This compound features several protective groups, including a benzoyl group and a dimethoxytrityl group, which help to stabilize the molecule during the synthesis process. The tert-butyl dimethylsilyl group provides additional protection for the 2'-hydroxyl group, enhancing the compound's stability and reactivity. The presence of the cyanoethyl group is crucial for the phosphoramidite's role in the phosphoramidite chemistry, facilitating the coupling reaction during oligonucleotide synthesis. This compound is typically utilized in automated synthesizers for the production of DNA and RNA sequences, making it an essential reagent in molecular biology and genetic research. Its complex structure allows for selective reactions, ensuring high fidelity in the synthesis of nucleic acid sequences.
Formula:C53H66N7O8PSi
InChI:InChI=1S/C53H66N7O8PSi/c1-36(2)60(37(3)4)69(65-32-18-31-54)67-46-44(33-64-53(39-21-16-13-17-22-39,40-23-27-42(62-8)28-24-40)41-25-29-43(63-9)30-26-41)66-51(47(46)68-70(10,11)52(5,6)7)59-35-57-45-48(55-34-56-49(45)59)58-50(61)38-19-14-12-15-20-38/h12-17,19-30,34-37,44,46-47,51H,18,32-33H2,1-11H3,(H,55,56,58,61)/t44-,46-,47-,51-,69?/m1/s1
InChI key:FFXHNCNNHASXCT-RFMFGJHUSA-N
SMILES:CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1O[Si](C)(C)C(C)(C)C)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC
Synonyms:- 2'-TBDMS-rA(N-Bz) Phosphoramidite
- 5'-O-DMT-2'-TBDMS-rA(N-Bz)-3'-CEDPA
- Bz-rA Phosphoramidite
- N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-adenosine-3'-cyanoethyl Phosphoramidite
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Found 9 products.
Bz A β-Cyanoethyl Phosphoramidite
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormula:C53H66N7O8PSiColor and Shape:White Light Yellow PowderMolecular weight:987.44798DMT-2'O-TBDMS-rA(bz) Phosphoramidite
CAS:DMT-2'O-TBDMS-rA(bz) PhosphoramiditeFormula:C54H67N6O8PSiPurity:97%Color and Shape:SolidMolecular weight:987.20444Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
CAS:Formula:C53H66N7O8PSiPurity:96%Color and Shape:SolidMolecular weight:988.1925N6-Benzoyl-2''-O-tert-butyldimethylsilyl-5''-O-DMT-adenosine 3''-CE phosphoramidite
CAS:Formula:C53H66N7O8PSiPurity:≥ 98.0%Color and Shape:White to off-white powderMolecular weight:988.22Bz-rA Phosphoramidite
CAS:Bz-rA Phosphoramidite is used for ribonucleotides modification[1].Formula:C53H66N7O8PSiColor and Shape:SolidMolecular weight:988.19N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine 3'-CE phosphoramidite
CAS:Nucleoside phosphoramidites are used in the synthesis of oligonucleotides. Using a chemical approach rather than an enzymatic one allows quick and inexpensive access to custom-made oligonucleotides of the desired sequence. Contrarily to the enzymatic synthesis, the chemically synthesised oligonucleotide sequence is typically constructed in a 3’ to 5’ direction. N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine 3'-CE phosphoramidite, also called DMT-2’O-TBDMS-rA(bz) amidite, is used in the synthesis of cyclic di-AMP, a second messenger used in signal transduction in bacteria.Formula:C53H66N7O8PSiPurity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:988.22 g/molBz-rA Phosphoramidite
CAS:(2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramiditeFormula:C53H66N7O8PSiPurity:97%Molecular weight:988.19N6-Bz-5'-O-DMT-2'-O-TBDMS-A-CE, ≤0.2% KF
CAS:Purity:99%，≤0.2%（K.F.）Color and Shape:SolidMolecular weight:987.448Ref: 10-F556390
Discontinued product
![Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsily…](https://static.cymitquimica.com/products/IN/thumb/DA0038CQ.jpg)
