CAS 1052646-54-4

Formula: C20H17Cl2N3O2S

InChI: InChI=1S/C20H17Cl2N3O2S/c21-15-10-16(22)18-9-14(15)17-11-19(25-20(23)24-17)28-13-5-3-4-12(8-13)26-6-1-2-7-27-18/h3-5,8-11H,1-2,6-7H2,(H2,23,24,25)

InChI key: FLKKRILCGIEOOD-UHFFFAOYSA-N

SMILES: C1CCOC2=C(C=C(C(=C2)C3=CC(=NC(=N3)N)SC4=CC=CC(=C4)OC1)Cl)Cl

Antiproliferative agent-72

CAS: 1052646-54-4

Antiproliferative agent-72 (Compound 10) is an Hsp90 inhibitor with a dissociation constant (Kd) of 11 nM. It exhibits antiproliferative activity with IC50 values of 1.5 μM and 1.1 μM against HCT116 and NCI-N87 cells, respectively. Antiproliferative agent-72 is suitable for cancer research applications.

Formula: C₂₀H₁₇Cl₂N₃O₂S

Molecular weight: 434.34

Ref: TM-T212526