CAS 1056634-68-4: CYT-387

Description: CYT-387, with the CAS number 1056634-68-4, is a small molecule inhibitor primarily known for its role in targeting Janus kinases (JAKs), particularly JAK1 and JAK2. It has been investigated for its potential therapeutic applications in various hematological malignancies and autoimmune diseases due to its ability to modulate immune responses and inhibit abnormal cell proliferation. The compound exhibits a specific mechanism of action by interfering with the JAK-STAT signaling pathway, which is crucial for the regulation of hematopoiesis and immune function. In terms of its chemical properties, CYT-387 is characterized by its molecular structure, which includes specific functional groups that contribute to its biological activity. The substance is typically administered in a pharmaceutical context, and its efficacy and safety profiles are evaluated through clinical trials. As with many investigational drugs, ongoing research continues to explore its full potential and any associated side effects.

Formula: C₂₃H₂₂N₆O₂

InChI: InChI=1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28)

InChI key: InChIKey=ZVHNDZWQTBEVRY-UHFFFAOYSA-N

SMILES: N#CCNC(=O)C=1C=CC(=CC1)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4

Synonyms:

• Benzamide, N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-
• CYT 387 mesylate
• Cyt 11387
• Cyt-0387
• Cyt387
• Gs 0387
• Momelotinib
• N-(Cyanomethyl)-4-[2-(4-morpholinoanilino)pyrimidin-4-yl]benzamide
• N-(Cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]benzamide
• CYT 387

N-(Cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]benzamide

CAS: 1056634-68-4

• Formula: C₂₃H₂₂N₆O₂
• Purity: %
• Color and Shape: Solid
• Molecular weight: 414.4598

N-(Cyanomethyl)-4-(2-((4-Morpholinophenyl)Amino)Pyrimidin-4-Yl)Benzamide

CAS: 1056634-68-4

• Molecular weight: 414.46g/mol

Momelotinib

CAS: 1056634-68-4

• Purity: ≥98%
• Molecular weight: 414.46g/mol

Momelotinib

CAS: 1056634-68-4

Momelotinib

CAS: 1056634-68-4

Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT …

• Formula: C₂₃H₂₂N₆O₂
• Purity: 97.47% - 99.56%
• Color and Shape: Solid
• Molecular weight: 414.46

Momelotinib

CAS: 1056634-68-4

• Formula: C₂₃H₂₂N₆O₂
• Molecular weight: 414.47

CYT 387

CAS: 1056634-68-4

Inhibits JAK1 and JAK2 kinases

• Formula: C₂₃H₂₂N₆O₂
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 414.18042

CYT387

CAS: 1056634-68-4

• Formula: C₂₃H₂₂N₆O₂
• Color and Shape: White
• Molecular weight: 414.46