CAS 105979-17-7

Benidipine

Description:

Benidipine is a calcium channel blocker primarily used in the treatment of hypertension and angina pectoris. It belongs to the dihydropyridine class of calcium antagonists, which function by inhibiting the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac tissue, leading to vasodilation and reduced cardiac workload. Benidipine exhibits a unique dual mechanism of action, as it blocks both L-type and T-type calcium channels, enhancing its efficacy in lowering blood pressure. The substance is characterized by its lipophilicity, which contributes to its ability to penetrate cell membranes effectively. It is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. Common side effects may include dizziness, headache, and peripheral edema, although it is generally well-tolerated. As with other medications in its class, caution is advised in patients with certain cardiovascular conditions or those taking other antihypertensive agents. Overall, Benidipine represents a valuable option in the management of cardiovascular diseases.

Formula: C₂₈H₃₂ClN₃O₆

InChI: InChI=1/C28H31N3O6/c1-18-24(27(32)36-3)26(21-11-7-12-22(15-21)31(34)35)25(19(2)29-18)28(33)37-23-13-8-14-30(17-23)16-20-9-5-4-6-10-20/h4-7,9-12,15,23,26,29H,8,13-14,16-17H2,1-3H3/t23-,26-/m1/s1

InChI key: InChIKey=QZVNQOLPLYWLHQ-MKNUCDGGNA-N

SMILES: C(O[C@H]1CN(CC2=CC=CC=C2)CCC1)(=O)C=3[C@@H](C(C(OC)=O)=C(C)NC3C)C4=CC(N(=O)=O)=CC=C4

Synonyms:

• (3R)-1-benzylpiperidin-3-yl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• (3R)-1-benzylpiperidin-3-yl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride (1:1)
• (3R)-1-benzylpiperidin-3-yl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester, (4R)-rel-
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3R)-1-(phenylmethyl)-3-piperidinyl ester, (4R)-rel-
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, (R*,R*)-
• BND
• Benidipine Hcl
• Capadipine
• Nacadipine
• (±)-Benidipine
• Benidipine
• (R^<*>^，R^<*>^)-(±)-2，6-dimethyl-4-(3-nitrophenyl)-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl(R^<*>^)-1-BenzyI-3-piperidylester
• BENIDIPINE HYDROCHLORIDE
• (4R)-2,6-Dimethyl-1,4-dihydro-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-methyl 5-[(3R)-1-benzylpiperidin-3-yl] ester
• CONIEL
• (+/-)-(R*)-3-((R*)-1-Benzyl-3-piperidyl) methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
• (4R)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-methyl 5-[(3R)-1-benzylpiperidin-3-yl] ester

Benidipine

CAS: 105979-17-7

Formula: C₂₈H₃₁N₃O₆

Molecular weight: 505.56

Ref: 7W-GP5445

Benidipine Hydrochloride

CAS: 105979-17-7, 91599-74-5

Formula: C₂₈H₃₁N₃O₆·HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: Light yellow to Yellow to Orange powder to crystal

Molecular weight: 542.03

Ref: 3B-B5629

Benidipine

CAS: 105979-17-7

Benidipine: potent oral calcium blocker, boosts nitric oxide synthase, enhances coronary flow, protects heart cells post-ischemia.

Formula: C₂₈H₃₁N₃O₆

Color and Shape: Solid

Molecular weight: 505.56

Ref: TM-T63452

Benidipine

CAS: 105979-17-7

Benidipine is a calcium channel blocker that inhibits the flow of calcium ions into cardiac and smooth muscle cells, which decreases the rate of these cells' contractions. Benidipine also has been shown to have a protective effect on the heart by preventing injury from coronary artery disease and other cardiovascular diseases. In addition, benidipine is not broken down in the liver and has a low risk of drug interactions. Benidipine has been found to be effective in reducing blood pressure in patients with chronic renal failure, although it may cause tubulointerstitial injury. The effects of benidipine are thought to be due to its ability to inhibit the release of growth factor-β1 from human polymorphonuclear leukocytes (PMNLs) and inhibit the proliferation of HL-60 cells.

Purity: Min. 95%

Ref: 3D-FB176235

Benidipine 5-(1-Benzylpiperidin-3-yl)-d10

Controlled Product

CAS: 105979-17-7

Formula: C₃₉D₁₀H₃₄N₄O₆

Color and Shape: Neat

Molecular weight: 674.851

Ref: TR-B157507