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CAS 105979-17-7

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Benidipine

Description:
Benidipine is a calcium channel blocker primarily used in the treatment of hypertension and angina pectoris. It belongs to the dihydropyridine class of calcium antagonists, which function by inhibiting the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac tissue, leading to vasodilation and reduced cardiac workload. Benidipine exhibits a unique dual mechanism of action, as it blocks both L-type and T-type calcium channels, enhancing its efficacy in lowering blood pressure. The substance is characterized by its lipophilicity, which contributes to its ability to penetrate cell membranes effectively. It is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. Common side effects may include dizziness, headache, and peripheral edema, although it is generally well-tolerated. As with other medications in its class, caution is advised in patients with certain cardiovascular conditions or those taking other antihypertensive agents. Overall, Benidipine represents a valuable option in the management of cardiovascular diseases.
Formula:C28H32ClN3O6
InChI:InChI=1/C28H31N3O6/c1-18-24(27(32)36-3)26(21-11-7-12-22(15-21)31(34)35)25(19(2)29-18)28(33)37-23-13-8-14-30(17-23)16-20-9-5-4-6-10-20/h4-7,9-12,15,23,26,29H,8,13-14,16-17H2,1-3H3/t23-,26-/m1/s1
InChI key:InChIKey=QZVNQOLPLYWLHQ-MKNUCDGGNA-N
SMILES:C(O[C@H]1CN(CC2=CC=CC=C2)CCC1)(=O)C=3[C@@H](C(C(OC)=O)=C(C)NC3C)C4=CC(N(=O)=O)=CC=C4
Synonyms:
  • (3R)-1-benzylpiperidin-3-yl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • (3R)-1-benzylpiperidin-3-yl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride (1:1)
  • (3R)-1-benzylpiperidin-3-yl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester, (4R)-rel-
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3R)-1-(phenylmethyl)-3-piperidinyl ester, (4R)-rel-
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, (R*,R*)-
  • BND
  • Benidipine Hcl
  • Capadipine
  • Nacadipine
  • See more synonyms
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