CAS 1062169-56-5

WYE-354

Description:

WYE-354, identified by its CAS number 1062169-56-5, is a chemical compound that has garnered attention in the field of medicinal chemistry, particularly for its potential therapeutic applications. It is classified as a small molecule inhibitor, specifically targeting certain protein kinases, which play crucial roles in various cellular processes, including cell growth and division. The compound exhibits a unique structure that allows it to interact selectively with its target, potentially leading to the modulation of signaling pathways associated with diseases such as cancer. WYE-354 has been studied for its efficacy in preclinical models, demonstrating promising results in inhibiting tumor growth. Additionally, its pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion, are critical for determining its suitability for further development as a therapeutic agent. As research continues, WYE-354 may contribute to the advancement of targeted therapies in oncology and other related fields. However, detailed studies are necessary to fully understand its safety profile and therapeutic potential.

Formula: C₂₄H₂₉N₇O₅

InChI: InChI=1S/C24H29N7O5/c1-34-23(32)26-17-5-3-16(4-6-17)20-27-21(29-11-13-36-14-12-29)19-15-25-31(22(19)28-20)18-7-9-30(10-8-18)24(33)35-2/h3-6,15,18H,7-14H2,1-2H3,(H,26,32)

SMILES: COC(=O)Nc1ccc(cc1)c1nc(c2cnn(C3CCN(CC3)C(=O)OC)c2n1)N1CCOCC1

Synonyms:

• 4-[6-[4-[(Methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic acid methyl ester
• Methyl 4-[6-{4-[(methoxycarbonyl)amino]phenyl}-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylate
• WYE-354;WYE 354; WYE354
• WYE-354 USP/EP/BP
• CS-441
• methyl 4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate
• 1-Piperidinecarboxylic acid, 4-[6-[4-[(methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-, methyl ester
• Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pip
• WYE-354
• WYE-354 (Degrasyn)

WYE-354

CAS: 1062169-56-5

Formula: C₂₄H₂₉N₇O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 495.5310

Ref: IN-DA008SST

Methyl 4-(6-(4-((Methoxycarbonyl)Amino)Phenyl)-4-Morpholino-1H-Pyrazolo[3,4-D]Pyrimidin-1-Yl)Piperidine-1-Carboxylate

CAS: 1062169-56-5

Methyl 4-(6-(4-((Methoxycarbonyl)Amino)Phenyl)-4-Morpholino-1H-Pyrazolo[3,4-D]Pyrimidin-1-Yl)Piperidine-1-Carboxylate

Purity: 98%

Molecular weight: 495.53g/mol

Ref: 54-OR1023238

WYE-354

CAS: 1062169-56-5

WYE-354

Purity: ≥95%

Molecular weight: 495.53g/mol

Ref: 54-BUP10653

WYE-354

CAS: 1062169-56-5

WYE-354 is a selective mTOR inhibitor (IC50=5 nM), targeting mTORC1/C2 over PI3Kα (>100x) and PI3Kγ (>500x), sparing P-AKT(T308).

Formula: C₂₄H₂₉N₇O₅

Purity: 97.86% - 99.61%

Color and Shape: Solid

Molecular weight: 495.53

Ref: TM-T6731

WYE 354

Controlled Product

CAS: 1062169-56-5

Formula: C₂₄H₂₉N₇O₅

Color and Shape: Neat

Molecular weight: 495.531

Ref: TR-W950000

mTOR Kinase Inhibitor II, WYE-354

CAS: 1062169-56-5

WYE-354 is a pyrimidine compound that inhibits mTOR kinase, the target of rapamycin. It has been shown to inhibit the production of pro-angiogenic factors and to be an immunosuppressant in vitro and in vivo. WYE-354 also reduces senescent cells, metabolic disorders, and prostate cancer cell growth. The drug increases autophagy levels and induces autophagy in vitro. This drug has not been tested on infectious diseases or autoimmune diseases as of yet.

Formula: C₂₄H₂₉N₇O₅

Purity: Min. 95%

Molecular weight: 495.53 g/mol

Ref: 3D-MSB16956