CAS 106400-81-1

Lometrexol

Description:

Lometrexol is a chemical compound classified as an antifolate, primarily known for its role in cancer treatment, particularly in the context of leukemia and other malignancies. It functions by inhibiting dihydrofolate reductase (DHFR), an enzyme critical for DNA synthesis and cell proliferation, thereby impeding the growth of rapidly dividing cancer cells. Lometrexol is characterized by its structural similarity to folate, which allows it to effectively compete with natural substrates for binding to DHFR. This compound is typically administered in a clinical setting and has been studied for its potential in combination therapies to enhance the efficacy of other anticancer agents. Its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are essential for determining appropriate dosing regimens. Additionally, like many chemotherapeutic agents, Lometrexol may exhibit side effects, necessitating careful monitoring of patients during treatment. Overall, Lometrexol represents a significant advancement in targeted cancer therapy, contributing to the broader field of oncology pharmacology.

Formula: C₂₁H₂₅N₅O₆

InChI: InChI=1/C21H25N5O6/c22-21-25-17-14(19(30)26-21)9-12(10-23-17)2-1-11-3-5-13(6-4-11)18(29)24-15(20(31)32)7-8-16(27)28/h3-6,12,15H,1-2,7-10H2,(H,24,29)(H,27,28)(H,31,32)(H4,22,23,25,26,30)/t12-,15+/m1/s1

Synonyms:

• Lometrexolum
• Lometrexolum [INN-Latin]
• Unii-6P3Avy8A7Q
• L-Glutamic acid, N-(4-(2-((6R)-2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-d)pyrimidin-6-yl)ethyl)benzoyl)-
• L-Glutamic acid, N-(4-(2-(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-d)pyrimidin-6-yl)ethyl)benzoyl)-, (R)-
• N-(4-{2-[(6R)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl}benzoyl)-L-glutamic acid

Lometrexol

CAS: 106400-81-1

Lometrexol

Purity: ≥95%

Molecular weight: 443.45g/mol

Ref: 54-BUP09563

Lometrexol hydrate

CAS: 106400-81-1

Formula: C₂₁H₂₅N₅O₆

Molecular weight: 443.45

Ref: 7W-GP3541

Lometrexol Hydrate

Controlled Product

CAS: 106400-81-1

Applications It is an antifolate which inhibits glycinamide ribonucleotide formyltransferase (GARFT), an enzyme essential for de novo purine synthesis. Lometrexol has activity against tumors which are refractory to other drugs, notably Methotrexate.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gibbs, D., et al.: Cancer Res., 65, 11721 (2005), Gangjee, A., et al.: J. Med. Chem., 48, 5329 (2005), Hilgenbrink, A., et al.: J. Pharm. Sci., 94, 2135 (2005),

Formula: C₂₁H₂₅N₅O₆·xH₂O

Color and Shape: Neat

Molecular weight: 443.45 + x(18.02)

Ref: TR-L469465

Lometrexol Hydrate

CAS: 106400-81-1

Lometrexol is an anti-cancer drug that belongs to the class of polymerase chain inhibitors. It inhibits the proliferation of cancer cells by binding to intracellular targets and interfering with DNA synthesis. Lometrexol is used to treat bowel disease, such as ulcerative colitis and Crohn's disease, which are caused by inflammation in the colon. Lometrexol has also been shown to have anti-inflammatory properties. The compound has been shown to inhibit transfer reactions in vitro, and low potency against infectious diseases. Lometrexol Hydrate is a prodrug that is hydrolyzed in vivo to lometrexol.

Formula: C₂₁H₂₅N₅O₆·xH₂O

Purity: Min. 95%

Molecular weight: 443.45 g/mol

Ref: 3D-GEA40081

Lometrexol

CAS: 106400-81-1

Lometrexol (LY 264618) is an antifolate that inhibits GARFT, blocks purine synthesis, induces apoptosis, and has anticancer properties.

Formula: C₂₁H₂₅N₅O₆

Purity: 97.76% - 99.56%

Color and Shape: Solid

Molecular weight: 443.45

Ref: TM-T15826