CAS 106627-54-7

N-Hydroxysulfosuccinimide sodium salt

Description:

N-Hydroxysulfosuccinimide sodium salt, commonly referred to as sulfo-NHS, is a water-soluble reagent widely used in bioconjugation and protein labeling applications. It is characterized by its ability to form stable amide bonds with primary amines, making it particularly useful for modifying proteins and other biomolecules. The compound features a sulfonic acid group, which enhances its solubility in aqueous solutions, and a hydroxysuccinimide moiety that facilitates the coupling reaction. Sulfo-NHS is often employed in the preparation of bioconjugates, such as antibodies or peptides, for use in various biochemical assays and therapeutic applications. Its reactivity is typically higher than that of traditional NHS esters, allowing for efficient conjugation under mild conditions. Additionally, the sodium salt form ensures compatibility with biological systems, minimizing potential interference in cellular environments. Overall, N-hydroxysulfosuccinimide sodium salt is a valuable tool in chemical biology and biochemistry for its specificity and efficiency in modifying biomolecules.

Formula: C₄H₄NNaO₆S

InChI: InChI=1/C4H5NO6S.Na/c6-3-1-2(12(9,10)11)4(7)5(3)8;/h2,8H,1H2,(H,9,10,11);/q;+1/p-1

SMILES: C1C(C(=O)N(C1=O)O)S(=O)(=O)O.[Na]

Synonyms:

• Sulfo-Nhs
• Sulfo-Nhs Sodium Salt
• Sulpho Nhs
• Nhss
• Nhss, Sodium Salt
• N-Hydroxysuccinimide Sulfonic Acid Sodium Salt
• N-Hydroxysulfosuccinimide
• Sodium 1-Hydroxy-2,5-Dioxopyrrolidine-3-Sulfonate
• 1-Hydroxy-2,5-Dioxopyrrolidine-3-Sulfonic Acid
• N-bydroxysulfosuccinimide sodium salt
• N-HYDROXYSULFOSUCCINIMIDE, SODIUM SALT

N-Hydroxysulfosuccinimide Sodium Salt

CAS: 106627-54-7

Formula: C₄H₄NNaO₆S

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 217.13

Ref: 3B-H1304

N-Hydroxysulfosuccinimide sodium salt, 97%

CAS: 106627-54-7

N-Hydroxysulfosuccinimide sodium salt is used as crosslinking agents for preparing hydrophilic active esters. It is also used to activate carboxylic acids to the more reactive succinimidyl esters for coupling, biotinylation and conjugation with fluorophores. Further, it acts as a hydrophilic ligand

Formula: C₄H₄NNaO₆S

Purity: 97%

Color and Shape: White to pale cream or pale yellow, Powder

Molecular weight: 217.13

Ref: 02-H52795

N-HYDROXYSULFOSUCCINIMIDE SODIUM SALT

CAS: 106627-54-7

Formula: C₄H₄NNaO₆S

Purity: 95%

Color and Shape: Solid

Molecular weight: 217.1324

Ref: IN-DA003T2L

N-Hydroxysulfosuccinimide sodium

CAS: 106627-54-7

N-Hydroxysulfosuccinimide sodium

Formula: C₄H₄NNaO₆S

Purity: ≥98%

Molecular weight: 217.13

Ref: 54-BUP18566

N-Hydroxysulfosuccinimide sodium

CAS: 106627-54-7

N-Hydroxysulfosuccinimide sodium is a non-cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis.

Formula: C₄H₄NNaO₆S

Purity: 98.26% - 98.73%

Color and Shape: White Crystalline Solid

Molecular weight: 217.13

Ref: TM-T16225

N-Hydroxysulfosuccinimide, sodium salt

CAS: 106627-54-7

N-Hydroxysulfosuccinimide, sodium salt

Formula: C₄H₄NO₆S·Na

Purity: 97%

Color and Shape: Pale yellow Solid-Powder

Molecular weight: 217.13243

Ref: 54-OR307159

N-Hydroxysulfosuccinimide sodium salt

CAS: 106627-54-7

Formula: C₄H₄NNaO₆S

Purity: ≥ 98.0%

Color and Shape: White, off-white or faint yellow powder

Molecular weight: 217.13

Ref: 7W-GE9186

N-Hydroxysulfosuccinimide Sodium Salt

CAS: 106627-54-7

Applications N-Hydroxysulfosuccinimide Sodium Salt is a hydrophilic ligand for the preparation of active esters, which can be used for crosslinking agents.
References Klibanov, A.L., et al.: Appl. Biochem. Biotechnol., 22, 45 (1989), Marcussen, J., et al.: Anal. Biochem., 198, 318 (1991), Verheul, A.F.M., et al.: Infect. Immun., 59, 843 (1991),

Formula: C₄H₄NO₆S·Na

Color and Shape: Neat

Molecular weight: 217.13

Ref: TR-H954000

N-Hydroxysulfosuccinimide sodium salt

CAS: 106627-54-7

N-Hydroxysulfosuccinimide sodium salt is derived from N-hydroxysulfosuccinimide (Sulfo-NHS), it is water and organic soluble and can be used in conjunction with carbodiimides, such as EDC, to activate carboxylic acids as N-hydroxysulfosuccinimide esters which react with amines to afford the corresponding amides. The N-hydroxysulfosuccinimide ester is longer lived than the carboxylic acid-EDC adduct and thus improves the coupling reaction efficiency. This method has been used to study protein-protein interactions by making zero-length cross-linked proteins, to tag markers onto proteins and can be carried out in both the solid or solution phase.

Formula: C₄H₄NNaO₆S

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 217.13 g/mol

Ref: 3D-FH24507

N-Hydroxysulfosuccinimide sodium salt

CAS: 106627-54-7

Formula: C₄H₄NNaO₆S

Purity: 99.0%

Color and Shape: Crystalline Powder,Powder

Molecular weight: 217.13

Ref: 10-F038186