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CAS 106627-54-7

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N-Hydroxysulfosuccinimide sodium salt

Description:
N-Hydroxysulfosuccinimide sodium salt, commonly referred to as sulfo-NHS, is a water-soluble reagent widely used in bioconjugation and protein labeling applications. It is characterized by its ability to form stable amide bonds with primary amines, making it particularly useful for modifying proteins and other biomolecules. The compound features a sulfonic acid group, which enhances its solubility in aqueous solutions, and a hydroxysuccinimide moiety that facilitates the coupling reaction. Sulfo-NHS is often employed in the preparation of bioconjugates, such as antibodies or peptides, for use in various biochemical assays and therapeutic applications. Its reactivity is typically higher than that of traditional NHS esters, allowing for efficient conjugation under mild conditions. Additionally, the sodium salt form ensures compatibility with biological systems, minimizing potential interference in cellular environments. Overall, N-hydroxysulfosuccinimide sodium salt is a valuable tool in chemical biology and biochemistry for its specificity and efficiency in modifying biomolecules.
Formula:C4H4NNaO6S
InChI:InChI=1/C4H5NO6S.Na/c6-3-1-2(12(9,10)11)4(7)5(3)8;/h2,8H,1H2,(H,9,10,11);/q;+1/p-1
InChI key:RPENMORRBUTCPR-UHFFFAOYSA-M
SMILES:C1C(C(=O)N(C1=O)O)S(=O)(=O)O.[Na]
Synonyms:
  • Sulfo-Nhs
  • Sulfo-Nhs Sodium Salt
  • Sulpho Nhs
  • Nhss
  • Nhss, Sodium Salt
  • N-Hydroxysuccinimide Sulfonic Acid Sodium Salt
  • N-Hydroxysulfosuccinimide
  • Sodium 1-Hydroxy-2,5-Dioxopyrrolidine-3-Sulfonate
  • 1-Hydroxy-2,5-Dioxopyrrolidine-3-Sulfonic Acid
  • N-bydroxysulfosuccinimide sodium salt
  • N-HYDROXYSULFOSUCCINIMIDE, SODIUM SALT
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