CAS 107220-28-0

Cevimeline hydrochloride

Description:

Cevimeline hydrochloride is a synthetic compound primarily used as a medication to treat dry mouth, particularly in patients with Sjögren's syndrome. It acts as a muscarinic agonist, stimulating the salivary glands to increase saliva production. The substance is characterized by its chemical formula, which includes a chiral center, leading to specific stereoisomeric properties that contribute to its pharmacological activity. Cevimeline hydrochloride is typically administered orally and is known for its relatively good bioavailability. Its mechanism of action involves the activation of M3 muscarinic receptors, which are predominantly found in salivary glands, thereby promoting exocrine secretion. The compound is generally well-tolerated, though it may cause side effects such as sweating, nausea, and gastrointestinal disturbances. As with any medication, it is essential to consider contraindications and potential interactions with other drugs. Overall, Cevimeline hydrochloride represents a targeted therapeutic approach for alleviating symptoms associated with xerostomia.

Formula: C₁₀H₁₇NOS·ClH

InChI: InChI=1/C10H17NOS.ClH/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11;/h8-9H,2-7H2,1H3;1H/t8-,10-;/s2

InChI key: InChIKey=SURWTGAXEIEOGY-IJFDQORBNA-N

SMILES: C[C@@H]1O[C@@]2([C@@H]3CCN(C2)CC3)CS1.Cl

Synonyms:

• Af 102B
• Cevimeline hydrochloride
• Evoxac
• Fks 508
• Saligren
• Snd 5008
• Sni 2011
• Snk 508
• Spiro(1-azabicyclo(2.2.2)octane-3,5'-(1,3)oxathiolane), 2'-methyl-, hydrochloride, cis-
• Spiro(1-azabicyclo(2.2.2)octane-3,5'-(1,3)oxathiolane), 2'-methyl-, hydrochloride, trans-
• Spiro[1-azabicyclo[2.2.2]octane-3,5′-[1,3]oxathiolane], 2′-methyl-, hydrochloride (1:1), (2′R,3R)-rel-
• Spiro[1-azabicyclo[2.2.2]octane-3,5′-[1,3]oxathiolane], 2′-methyl-, hydrochloride, (2′R,3R)-rel-
• cis-(+-)-2'-Methylspiro(1-azabicyclo(2.2.2)octane-3,5'-(1,3)oxathiolane) hydrochloride
• cis-2-Methylspiro[1,3-oxathiolane-5,3′-quinuclidine] hydrochloride

Cevimeline Hydrochloride Salt

CAS: 107220-28-0

Formula: C₁₀H₁₈ClNOS

Purity: 91%

Color and Shape: Solid

Molecular weight: 235.7740

Ref: IN-DA007AU5

rel-(2R,3'R)-2-Methyl-1'-azaspiro[[1,3]oxathiolane-5,3'-bicyclo[2.2.2]octane] hydrochloride

CAS: 107220-28-0

rel-(2R,3'R)-2-Methyl-1'-azaspiro[[1,3]oxathiolane-5,3'-bicyclo[2.2.2]octane] hydrochloride

Formula: C₁₀H₁₈ClNOS

Purity: 91%

Molecular weight: 235.78

Ref: 54-OR1073972

Cevimeline HCl

CAS: 107220-28-0

Formula: C₁₀H₁₇NOS·HCl

Molecular weight: 199.31 36.46

Ref: 4Z-C-209021

Cevimeline hydrochloride

CAS: 107220-28-0

Cevimeline HCl is a muscarinic agonist enhancing salivary and sweat gland secretion.

Formula: C₁₀H₁₈ClOS

Color and Shape: Solid

Molecular weight: 235.77

Ref: TM-T20131

Cevimeline-d4 Hydrochloride Salt (Major)

Controlled Product

CAS: 107220-28-0

Applications A labelled muscarinic M1 and M3 receptor agonist. Sialagogue.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Masunaga, H., et al.: Eur. J. Pharmacol., 339, 1 (1997), Arisawa, H., et al.: Arzneim.-Forsch., 52, 14 (2002), Yasuda, H., et al.: Clin. Drug Invest., 22, 67 (2002), Ono, M., et al.: Am. J. Ophthalmol., 138, 6 (2004),

Formula: C₁₀H₁₄D₄ClNOS

Color and Shape: Neat

Molecular weight: 239.8

Ref: TR-C283502

rac,cis-Cevimeline Hydrochloride Salt

Controlled Product

CAS: 107220-28-0

Formula: C₁₀H₁₇NOS·ClH

Color and Shape: Neat

Molecular weight: 235.77

Ref: TR-C283500

Cevimeline hydrochloride

CAS: 107220-28-0

Ref: BE-RMCC180001

Cevimeline HCl

CAS: 107220-28-0

rel-(2R,3'R)-2-Methyl-1'-azaspiro[[1,3]oxathiolane-5,3'-bicyclo[2.2.2]octane] hydrochloride

Formula: C₁₀H₁₈ClNOS

Purity: 91% HPLC

Molecular weight: 235.77

Ref: IN-DG629877

Cevimeline hydrochloride

CAS: 107220-28-0

Cevimeline hydrochloride salt is a cholinergic drug that activates the muscarinic receptors in the salivary glands. It has been used for the treatment of dry mouth and xerostomia in patients with Sjögren's syndrome, diabetes, or following radiation therapy. Cevimeline hydrochloride has been shown to increase the production of saliva in animal models of Sjögren's syndrome by stimulating cAMP-dependent protein kinase A (PKA) activity. This drug also has anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis. Cevimeline hydrochloride salt can cause side effects such as eye disorders, skin cancer, and geriatric patients with adenosine A3 receptor antagonists. Benzalkonium chloride is an ingredient in cevimeline hydrochloride salt that acts as a preservative and antimicrobial agent.

Formula: C₁₀H₁₇NOS•HCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 235.77 g/mol

Ref: 3D-FC19916

Cevimeline HCl

CAS: 107220-28-0

Formula: C₁₀H₁₇NOSHCl

Molecular weight: 199.27 : 36.5

Ref: ST-EA-CP-C62001