CAS 107724-20-9

(+)-Eplerenone

Description:

(+)-Eplerenone is a synthetic steroid and a selective aldosterone antagonist, primarily used in the treatment of hypertension and heart failure. It is characterized by its ability to block the effects of aldosterone, a hormone that regulates sodium and potassium levels in the body, thereby promoting diuresis and reducing blood pressure. The compound has a unique molecular structure that includes a lactone ring and a spiro structure, contributing to its specificity and potency. (+)-Eplerenone exhibits good oral bioavailability and is metabolized primarily in the liver, with a half-life that allows for once-daily dosing. Its pharmacological profile includes a favorable side effect profile compared to other diuretics, with a lower incidence of hyperkalemia. Additionally, it has been shown to improve outcomes in patients with heart failure post-myocardial infarction. Overall, (+)-Eplerenone represents an important therapeutic option in cardiovascular medicine, particularly for patients with conditions related to excess aldosterone.

Formula: C₂₄H₃₀O₆

InChI: InChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1

InChI key: InChIKey=JUKPWJGBANNWMW-VWBFHTRKSA-N

SMILES: C[C@@]12[C@]34[C@]([C@]5([C@](C)(C[C@]3(O4)[H])[C@@]6(CC5)CCC(=O)O6)[H])([C@H](C(OC)=O)CC1=CC(=O)CC2)[H]

Synonyms:

• Cgp 30083
• Epoxymexrenone
• Inspra
• Pregn-4-Ene-7,21-Dicarboxylic Acid 9,11-Epoxy-17-Hydroxy-3-Oxo Gamma-Lactone Methyl Ester
• Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, γ-lactone, 7-methyl ester, (7α,11α,17α)-
• Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, γ-lactone, methyl ester, (7α,11α,17α)-
• Sc 6110
• Sc 66110
• Selara
• Spiro[9,11-epoxy-9H-cyclopenta[a]phenanthrene-17(2H),2′(3′H)-furan], pregn-4-ene-7,21-dicarboxylic acid deriv.
• The Intermediates
• methyl (4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate
• methyl (4aS,4bR,5aR,6aS,7S,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate
• methyl (4aS,4bR,5aS,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate

Eplerenone

CAS: 107724-20-9

Formula: C₂₄H₃₀O₆

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 414.50

Ref: 3B-E0905

EPLERENONE FOR PEAK IDENTIFICATION CRS

CAS: 107724-20-9

EPLERENONE FOR PEAK IDENTIFICATION CRS

Formula: C₂₄H₃₀O₆

Color and Shape: Powder

Molecular weight: 414.4914

Ref: 41-Y0001706

EPLERENONE FOR SYSTEM SUITABILITY CRS

CAS: 107724-20-9

EPLERENONE FOR SYSTEM SUITABILITY CRS

Formula: C₂₄H₃₀O₆

Color and Shape: Powder

Molecular weight: 414.4914

Ref: 41-Y0001705

EPLERENONE CRS

CAS: 107724-20-9

EPLERENONE CRS

Ref: 41-Y0001704

Eplerenone

CAS: 107724-20-9

Adrenal cortical hormones and their derivatives nesoi

Formula: C₂₄H₃₀O₆

Color and Shape: White Off-White Crystalline Powder

Molecular weight: 414.20424

Ref: 45-1237553

Eplerenone

CAS: 107724-20-9

Eplerenone (CGP 30083) is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy of hypertension.

Formula: C₂₄H₃₀O₆

Purity: 99.75% - ≥98%

Color and Shape: White Solid

Molecular weight: 414.49

Ref: TM-T0083

Eplerenone

CAS: 107724-20-9

Eplerenone

Purity: 99%

Molecular weight: 414.49g/mol

Ref: 54-OR1027366

Eplerenone

CAS: 107724-20-9

Formula: C₂₄H₃₀O₆

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 414.49

Ref: 7W-GP0150

Eplerenone-d3

CAS: 107724-20-9

Formula: C₂₄H₂₇D₃O₆

Color and Shape: White To Off-White Solid

Molecular weight: 417.52

Ref: 4Z-E-132

Eplerenone

CAS: 107724-20-9

Eplerenone

Purity: ≥98%

Molecular weight: 414.49g/mol

Ref: 54-BUP11927

Eplerenone

CAS: 107724-20-9

Formula: C₂₄H₃₀O₆

Color and Shape: White To Off-White Solid

Molecular weight: 414.50

Ref: 4Z-E-133

Eplerenone

Controlled Product

CAS: 107724-20-9

Formula: C₂₄H₃₀O₆

Color and Shape: Neat

Molecular weight: 414.49

Ref: 04-C13179750

Eplerenone

CAS: 107724-20-9

Formula: C₂₄H₃₀O₆

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 414.498

Ref: 10-F093379

Eplerenone

Controlled Product

CAS: 107724-20-9

Formula: C₂₄H₃₀O₆

Color and Shape: Neat

Molecular weight: 414.49

Ref: 86-MM3530.00

Eplerenone-13C-d3

CAS: 107724-20-9

Formula: C₂₄H₂₇O₆D₃

Molecular weight: 418.51

Ref: 4Z-E-134

PEG (n=25)

CAS: 107724-20-9

Formula: C₅₀H₁₀₂O₂₆

Molecular weight: 1119.34

Ref: 4Z-E-134027

Eplerenone RS

CAS: 107724-20-9

Color and Shape: White Solid Crystalline Powder

Ref: 2K-1028100021

Eplerenone-d3

Controlled Product

CAS: 107724-20-9

Applications Selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.
References de Gasparo, M., et al.: J. Pharmacol. Exp. Ther., 240, 650 (1987), Delyani, J.A., et al.: Cardiovasc. Drug Rev., 19, 185 (2001), Burgess, E., et al.: Expert. Opin. Pharmacother., 5, 2573 (2004), Ravis, W.R., et al.: J. Clin. Pharmacol., 45, 810 (2005),

Formula: C₂₄H₂₇D₃O₆

Color and Shape: Neat

Molecular weight: 417.51

Ref: TR-E588777

Eplerenone

CAS: 107724-20-9

Applications Selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.
References de Gasparo, M., et al.: J. Pharmacol. Exp. Ther., 240, 650 (1987), Delyani, J.A., et al.: Cardiovasc. Drug Rev., 19, 185 (2001), Burgess, E., et al.: Expert. Opin. Pharmacother., 5, 2573 (2004), Ravis, W.R., et al.: J. Clin. Pharmacol., 45, 810 (2005),

Formula: C₂₄H₃₀O₆

Color and Shape: Neat

Molecular weight: 414.49

Ref: TR-E588775

Eplerenone

CAS: 107724-20-9

Aldosterone blocker

Formula: C₂₄H₃₀O₆

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 414.49 g/mol

Ref: 3D-FP22747