CAS 107724-20-9: (+)-Eplerenone

Description: (+)-Eplerenone is a synthetic steroid and a selective aldosterone antagonist, primarily used in the treatment of hypertension and heart failure. It is characterized by its ability to block the effects of aldosterone, a hormone that regulates sodium and potassium levels in the body, thereby promoting diuresis and reducing blood pressure. The compound has a unique molecular structure that includes a lactone ring and a spiro structure, contributing to its specificity and potency. (+)-Eplerenone exhibits good oral bioavailability and is metabolized primarily in the liver, with a half-life that allows for once-daily dosing. Its pharmacological profile includes a favorable side effect profile compared to other diuretics, with a lower incidence of hyperkalemia. Additionally, it has been shown to improve outcomes in patients with heart failure post-myocardial infarction. Overall, (+)-Eplerenone represents an important therapeutic option in cardiovascular medicine, particularly for patients with conditions related to excess aldosterone.

Formula: C₂₄H₃₀O₆

InChI: InChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1

InChI key: InChIKey=JUKPWJGBANNWMW-VWBFHTRKSA-N

SMILES: O=C1OC2(CC1)CCC3C4C(C(=O)OC)CC5=CC(=O)CCC5(C)C64OC6CC32C

Synonyms:

• Cgp 30083
• Epoxymexrenone
• Inspra
• Pregn-4-Ene-7,21-Dicarboxylic Acid 9,11-Epoxy-17-Hydroxy-3-Oxo Gamma-Lactone Methyl Ester
• Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, γ-lactone, 7-methyl ester, (7α,11α,17α)-
• Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, γ-lactone, methyl ester, (7α,11α,17α)-
• Sc 6110
• Sc 66110
• Selara
• Spiro[9,11-epoxy-9H-cyclopenta[a]phenanthrene-17(2H),2′(3′H)-furan], pregn-4-ene-7,21-dicarboxylic acid deriv.
• The Intermediates
• methyl (4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate
• methyl (4aS,4bR,5aR,6aS,7S,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate
• methyl (4aS,4bR,5aS,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate
• methyl (4aS,4bR,6aS,7R,9aS,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate

Eplerenone

CAS: 107724-20-9

• Formula: C₂₄H₃₀O₆
• Purity: >98.0%(HPLC)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 414.50

Eplerenone

CAS: 107724-20-9

• Purity: 95.0%
• Color and Shape: Solid
• Molecular weight: 414.49798583984375

Eplerenone for peak identification CRS

CAS: 107724-20-9

• Formula: C₂₄H₃₀O₆
• Color and Shape: Powder
• Molecular weight: 414.4914

Eplerenone for system suitability CRS

CAS: 107724-20-9

• Formula: C₂₄H₃₀O₆
• Color and Shape: Powder
• Molecular weight: 414.4914

Eplerenone CRS

CAS: 107724-20-9

Eplerenone

CAS: 107724-20-9

Adrenal cortical hormones and their derivatives nesoi

• Formula: C₂₄H₃₀O₆
• Color and Shape: White Off-White Crystalline Powder
• Molecular weight: 414.20424

Eplerenone

CAS: 107724-20-9

Eplerenone (CGP 30083) is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy …

• Formula: C₂₄H₃₀O₆
• Purity: 99.75% - ≥98%
• Color and Shape: White Solid
• Molecular weight: 414.49

Eplerenone

CAS: 107724-20-9

• Formula: C₂₄H₃₀O₆
• Color and Shape: White To Off-White Solid
• Molecular weight: 414.50

Eplerenone

CAS: 107724-20-9

• Molecular weight: 414.49g/mol

Eplerenone

CAS: 107724-20-9

• Formula: C₂₄H₃₀O₆
• Purity: ≥ 98.0%
• Color and Shape: White to off-white powder
• Molecular weight: 414.49

Eplerenone-d3

CAS: 107724-20-9

• Formula: C₂₄H₂₇D₃O₆
• Color and Shape: White To Off-White Solid
• Molecular weight: 417.52

Eplerenone

CAS: 107724-20-9

• Formula: C₂₄H₃₀O₆
• Color and Shape: Neat
• Molecular weight: 414.49

Eplerenone

CAS: 107724-20-9

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₂₄H₃₀O₆
• Color and Shape: White to light yellow, Crystalline powder
• Molecular weight: 414.50

Eplerenone

CAS: 107724-20-9

• Formula: C₂₄H₃₀O₆
• Color and Shape: Neat
• Molecular weight: 414.49

Eplerenone-13C-d3

CAS: 107724-20-9

• Formula: C₂₄H₂₇O₆D₃
• Molecular weight: 418.51

PEG (n=25)

CAS: 107724-20-9

• Formula: C₅₀H₁₀₂O₂₆
• Molecular weight: 1119.34

Eplerenone RS

CAS: 107724-20-9

• Color and Shape: White Solid Crystalline Powder

Eplerenone-d3

CAS: 107724-20-9

Applications Selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or …

• Formula: C₂₄H₂₇D₃O₆
• Color and Shape: Neat
• Molecular weight: 417.51

Eplerenone

CAS: 107724-20-9

Applications Selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or …

• Formula: C₂₄H₃₀O₆
• Color and Shape: Neat
• Molecular weight: 414.49

Eplerenone - Bio-X ™

CAS: 107724-20-9

Eplerenone is a drug known as an aldosterone antagonist. It is a type of potassium-sparing …

• Formula: C₂₄H₃₀O₆
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 414.49 g/mol