CAS 107724-20-9
:(+)-Eplerenone
Description:
(+)-Eplerenone is a synthetic steroid and a selective aldosterone antagonist, primarily used in the treatment of hypertension and heart failure. It is characterized by its ability to block the effects of aldosterone, a hormone that regulates sodium and potassium levels in the body, thereby promoting diuresis and reducing blood pressure. The compound has a unique molecular structure that includes a lactone ring and a spiro structure, contributing to its specificity and potency. (+)-Eplerenone exhibits good oral bioavailability and is metabolized primarily in the liver, with a half-life that allows for once-daily dosing. Its pharmacological profile includes a favorable side effect profile compared to other diuretics, with a lower incidence of hyperkalemia. Additionally, it has been shown to improve outcomes in patients with heart failure post-myocardial infarction. Overall, (+)-Eplerenone represents an important therapeutic option in cardiovascular medicine, particularly for patients with conditions related to excess aldosterone.
Formula:C24H30O6
InChI:InChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1
InChI key:InChIKey=JUKPWJGBANNWMW-VWBFHTRKSA-N
SMILES:C[C@@]12[C@]34[C@]([C@]5([C@](C)(C[C@]3(O4)[H])[C@@]6(CC5)CCC(=O)O6)[H])([C@H](C(OC)=O)CC1=CC(=O)CC2)[H]
Synonyms:- Cgp 30083
- Epoxymexrenone
- Inspra
- Pregn-4-Ene-7,21-Dicarboxylic Acid 9,11-Epoxy-17-Hydroxy-3-Oxo Gamma-Lactone Methyl Ester
- Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, γ-lactone, 7-methyl ester, (7α,11α,17α)-
- Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, γ-lactone, methyl ester, (7α,11α,17α)-
- Sc 6110
- Sc 66110
- Selara
- Spiro[9,11-epoxy-9H-cyclopenta[a]phenanthrene-17(2H),2′(3′H)-furan], pregn-4-ene-7,21-dicarboxylic acid deriv.
- The Intermediates
- methyl (4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate
- methyl (4aS,4bR,5aR,6aS,7S,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate
- methyl (4aS,4bR,5aS,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate
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Eplerenone
CAS:Formula:C24H30O6Purity:>98.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:414.50EPLERENONE FOR PEAK IDENTIFICATION CRS
CAS:<p>EPLERENONE FOR PEAK IDENTIFICATION CRS</p>Formula:C24H30O6Color and Shape:PowderMolecular weight:414.4914EPLERENONE FOR SYSTEM SUITABILITY CRS
CAS:<p>EPLERENONE FOR SYSTEM SUITABILITY CRS</p>Formula:C24H30O6Color and Shape:PowderMolecular weight:414.4914Eplerenone
CAS:Adrenal cortical hormones and their derivatives nesoiFormula:C24H30O6Color and Shape:White Off-White Crystalline PowderMolecular weight:414.20424Eplerenone
CAS:<p>Eplerenone (CGP 30083) is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy of hypertension.</p>Formula:C24H30O6Purity:99.75% - ≥98%Color and Shape:White SolidMolecular weight:414.49Eplerenone
CAS:Formula:C24H30O6Purity:≥ 98.0%Color and Shape:White to off-white powderMolecular weight:414.49Eplerenone-d3
CAS:Controlled Product<p>Applications Selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.<br>References de Gasparo, M., et al.: J. Pharmacol. Exp. Ther., 240, 650 (1987), Delyani, J.A., et al.: Cardiovasc. Drug Rev., 19, 185 (2001), Burgess, E., et al.: Expert. Opin. Pharmacother., 5, 2573 (2004), Ravis, W.R., et al.: J. Clin. Pharmacol., 45, 810 (2005),<br></p>Formula:C24H27D3O6Color and Shape:NeatMolecular weight:417.51Eplerenone
CAS:<p>Applications Selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.<br>References de Gasparo, M., et al.: J. Pharmacol. Exp. Ther., 240, 650 (1987), Delyani, J.A., et al.: Cardiovasc. Drug Rev., 19, 185 (2001), Burgess, E., et al.: Expert. Opin. Pharmacother., 5, 2573 (2004), Ravis, W.R., et al.: J. Clin. Pharmacol., 45, 810 (2005),<br></p>Formula:C24H30O6Color and Shape:NeatMolecular weight:414.49Eplerenone - Bio-X ™
CAS:<p>Eplerenone is a drug known as an aldosterone antagonist. It is a type of potassium-sparing diuretic that is used to treat chronic heart failure and high blood pressure, particularly for patients with resistant hypertension due to elevated aldosterone. It does this by blocking the activity of the enzyme that produces aldosterone, which increases levels of sodium and water in the body. This leads to a decrease in blood pressure.</p>Formula:C24H30O6Purity:Min. 95%Color and Shape:PowderMolecular weight:414.49 g/mol
