CAS 108050-54-0

tilmicosin

Description:

Tilmicosin is a semi-synthetic macrolide antibiotic primarily used in veterinary medicine, particularly for the treatment of respiratory infections in livestock, such as cattle and swine. It is derived from the fermentation of the bacterium *Streptomyces fradiae*. Tilmicosin exhibits a broad spectrum of activity against various Gram-positive bacteria and some Gram-negative bacteria, making it effective in combating infections caused by pathogens like *Mycoplasma* and *Pasteurella*. The compound works by inhibiting bacterial protein synthesis, thereby preventing the growth and reproduction of bacteria. Tilmicosin is typically administered via injection or in feed formulations, and it is known for its long half-life, allowing for less frequent dosing. However, it is important to note that tilmicosin can be toxic to certain animal species, particularly horses and humans, leading to potential safety concerns. As with all antibiotics, the use of tilmicosin should be managed carefully to prevent the development of antibiotic resistance.

Formula: C₄₆H₈₀N₂O₁₃

InChI: InChI=1/C46H80N2O13/c1-13-36-33(24-57-46-44(56-12)43(55-11)40(53)31(8)59-46)19-25(2)14-15-34(49)28(5)20-32(16-17-48-22-26(3)18-27(4)23-48)42(29(6)35(50)21-37(51)60-36)61-45-41(54)38(47(9)10)39(52)30(7)58-45/h14-15,19,26-33,35-36,38-46,50,52-54H,13,16-18,20-24H2,1-12H3/b15-14+,25-19+/t26-,27+,28-,29+,30-,31-,32+,33-,35-,36-,38+,39-,40-,41-,42-,43-,44-,45+,46-/m1/s1

InChI key: InChIKey=JTSDBFGMPLKDCD-XVFHVFLVSA-N

SMILES: O([C@H]1[C@@H](CCN2C[C@@H](C)C[C@@H](C)C2)C[C@@H](C)C(=O)/C=C/C(/C)=C/[C@H](CO[C@H]3[C@H](OC)[C@H](OC)[C@H](O)[C@@H](C)O3)[C@@H](CC)OC(=O)C[C@@H](O)[C@@H]1C)[C@H]4[C@H](O)[C@@H](N(C)C)[C@H](O)[C@@H](C)O4

Synonyms:

• 20-Deoxo-20-(3,5-Dimethyl-1-Piperidinyl)Desmycosin
• 4^A-O-De(2,6-dideoxy-3-C-methyl-α-<span class="text-smallcaps">L</span>-ribo-hexopyranosyl)-20-deoxo-20-[(3R,5S)-3,5-dimethyl-1-piperidinyl]tylosin
• 4A-O-De(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-20-deoxo-20-[(3R,5S)-3,5-dimethyl-1-piperidinyl]tylosin
• Antibiotic EL 870
• El 870
• Ly 177370
• Micotil
• Micotil 300
• Oxacyclohexadecane, tylosin deriv.
• Provitil
• Pulmotil
• Tilmicosin, Vetranal
• Tilmicosin  base
• Tylmicosine
• Tylosin, 4^A-O-de(2,6-dideoxy-3-C-methyl-α-<span class="text-smallcaps">L</span>-ribo-hexopyranosyl)-20-deoxo-20-[(3R,5S)-3,5-dimethyl-1-piperidinyl]-
• Tylosin, 4A-O-de(2,6-dideoxy-3-C-methyl-.alpha.-L-ribo-hexopyranosyl)-20-deoxo-20-(3R,5S)-3,5-dimethyl-1-piperidinyl-
• [(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-{[3,6-dideoxy-3-(dimethylamino)-beta-D-glucopyranosyl]oxy}-11-{2-[(3R,5S)-3,5-dimethylpiperidin-1-yl]ethyl}-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxooxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-2,3-di-O-methyl-beta-D-allopyranoside
• cis-Tilmicosin
• Tylosin, 4A-O-de(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-20-deoxo-20-[(3R,5S)-3,5-dimethyl-1-piperidinyl]-
• (11Z,13Z)-6-{[4-(diMethylaMino)-3,5-dihydroxy-6-Methyloxan-2-yl]oxy}-7-[2-(3,5-diMethylpiperidin-1-yl)ethyl]-16-ethyl-4-hydroxy-15-{[(5-hydroxy-3,4-diMethoxy-6-Methyloxan-2-yl)oxy]Methyl}-5,9,13-triMethyl-1-oxacyclohexadeca-11,13-diene-2,10-dione
• 20-Deoxy-20-(3,5-diMethylpiperidin-1-yl)-desMycosin, EL-870
• 20%Tilmicosin
• Tilmicosin,20-Deoxo-20-(3,5-dimethyl-1-piperidinyl)desmycosin
• TILMICOSIN
• 4'-O-De(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-20-deoxo-20-(3,5-dimethyl-1-piperidinyl)tyrosine [antibiotic]
• Tilmicosine
• Tilmicosin (250 mg)

Tilmicosin

CAS: 108050-54-0

Antibiotics nesoi

Formula: C₄₆H₈₀N₂O₁₃

Color and Shape: White Off-White Powder

Molecular weight: 868.56604

Ref: 45-1667370

Tilmicosin

CAS: 108050-54-0

Tilmicosin (EL-870), a macrolide antibiotic, treats bovine and ovine respiratory diseases in animals.

Formula: C₄₆H₈₀N₂O₁₃

Purity: 97.84% - 99.5%

Color and Shape: Solid

Molecular weight: 869.13

Ref: TM-T0777

Tilmicosin

CAS: 108050-54-0

Formula: C₄₆H₈₀N₂O₁₃

Purity: ≥ 85.0% (anhydrous basis)

Color and Shape: White to off-white powder

Molecular weight: 869.13

Ref: 7W-GP6895

Tilmicosin

CAS: 108050-54-0

Tilmicosin

Purity: ≥95%

Molecular weight: 869.13g/mol

Ref: 54-BUP19943

Tilmicosin

CAS: 108050-54-0

Tilmicosin

Purity: ≥98%

Molecular weight: 869.13g/mol

Ref: 54-BUP18452

Tilmicosin 100 µg/mL in Acetonitrile

CAS: 108050-54-0

Formula: C₄₆H₈₀N₂O₁₃

Color and Shape: Single Solution

Molecular weight: 869.13

Ref: 04-A17582000AL-100

Tilmicosin

Controlled Product

CAS: 108050-54-0

Formula: C₄₆H₈₀N₂O₁₃

Color and Shape: Neat

Molecular weight: 869.13

Ref: 04-C17582000

Tilmicosin

CAS: 108050-54-0

Formula: C₄₆H₈₀N₂O₁₃

Color and Shape: White To Off-White Solid

Molecular weight: 869.15

Ref: 4Z-T-193001

Tilmicosin, 85%

CAS: 108050-54-0

Applications Macrolide antibiotic structurally related to tylosin. Antibacterial.
References Debono, M., et al.: J. Antibiot., 42, 1253 (1989), Ose, E.E., et al.: Vet. Rec., 123, 367 (1988), Morck, D.W., et al.: J. Am. Vet. Med. Assoc., 202, 273 (1993),

Formula: C₄₆H₈₀N₂O₁₃

Purity: 85%

Color and Shape: White To Off-White

Molecular weight: 869.13

Ref: TR-T440500

Tilmicosin-d3

Controlled Product

CAS: 108050-54-0

Applications Tilmicosin-d3 is the labeled analogue of Tilmicosin (T440500), a macrolide antibiotic structurally related to tylosin. Antibacterial.
References Debono, M., et al.: J. Antibiot., 42, 1253 (1989); Ose, E.E., et al.: Vet. Rec., 123, 367 (1988); Morck, D.W., et al.: J. Am. Vet. Med. Assoc., 202, 273 (1993)

Formula: C₄₆H₇₇D₃N₂O₁₃

Color and Shape: White To Off-White

Molecular weight: 872.15

Ref: TR-T440502

Tilmicosin - Bio-X ™

CAS: 108050-54-0

Tilmicosin is a macrolide antibiotic that is used in veterinary medicine. It is used to treat bovine respiratory disease and inhibits bacterial growth by binding to the 50S ribosomal subunit of the bacteria resulting in reduced protein synthesis.

Formula: C₄₆H₈₀N₂O₁₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 869.13 g/mol

Ref: 3D-BT166387

Tilmicosin

CAS: 108050-54-0

Tilmicosin is a macrolide antibiotic with action on bacterial protein synthesis inhibition and is used for treating respiratory infections in cattle and sheep.

Formula: C₄₆H₈₀N₂O₁₃

Purity: Min. 85 Area-%

Color and Shape: White Powder

Molecular weight: 869.13 g/mol

Ref: 3D-AD31127