CAS 1088-11-5
:2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-phenyl-
Description:
2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-phenyl- is a chemical compound belonging to the benzodiazepine class, which is characterized by its fused benzene and diazepine rings. This compound typically exhibits properties such as sedative, anxiolytic, and muscle relaxant effects, making it relevant in pharmacology. The presence of a chlorine atom at the 7-position and a phenyl group at the 5-position contributes to its unique chemical reactivity and biological activity. It is often studied for its potential therapeutic applications, particularly in the treatment of anxiety and sleep disorders. The compound's structure allows for interactions with the central nervous system, primarily through modulation of GABA receptors, which are crucial for inhibitory neurotransmission. Additionally, its solubility and stability can vary based on environmental conditions, influencing its bioavailability and efficacy. Safety and handling precautions are essential due to its pharmacological properties, and it is subject to regulatory controls in many jurisdictions.
Formula:C15H11ClN2O
InChI:InChI=1/C15H11ClN2O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19)
InChI key:InChIKey=AKPLHCDWDRPJGD-UHFFFAOYSA-N
SMILES:ClC=1C=C2C(=NCC(=O)NC2=CC1)C3=CC=CC=C3
Synonyms:- 1-Demethyldiazepam
- 7-Chloro-1,3-dihydro-1H-5-phenyl-2H-1,4-benzodiazepin-2-one
- 7-Chloro-1,3-dihydro-5-phenyl-1,4-benzodiazepin-2-one
- 7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazapin-2-one
- 7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one
- 7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-one
- 7-Chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
- 7-Chloro-5-phenyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one
- 7-Chloro-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one
- 7-Chloro-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one
- 7-Chloro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
- 7-Chloro-5-phenyl-2-oxo-1,2-dihydro-1,4-benzodiazepine
- 7-Chloro-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one
- A 101
- Calmday
- Dealkylprazepam
- Demethyldiazepam
- Demoxazepam
- Desalkylprazepam
- Desmethyldiazepam
- Dmdz
- Madar
- N-Demethyldiazepam
- N-Deoxydemoxepam
- N-Descyclopropylmethylprazepam
- N-Desmethyldiazepam
- N1-Desmethyldiazepam
- N<sup>1</sup>-Desmethyldiazepam
- Nordaz
- Nordazepam
- Nordiazepam
- Norprazepam
- Nsc 46078
- Nsc 631619
- Praxadium
- Ro 5-2180
- Sigma D 7282
- Stilny
- 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-phenyl-
- 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-phenyl-
- DIAZEPAM, DESMETHYL (RO 5-2180, NORDIAZE P
- 7-Chloro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
- N-Deoxydemoxapam
- 1,4-BENZODIAZEPIN-2-ONE,7-CHLORO-1,3-DIHYDRO-5-PHENYL-
- NDD
- Nordiazepam solution
- Nordazepam CIV (50 mg) (7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one)
- Methanol (test Nordiazepam,1.0mg/mL)
- Ro 52180434
- Chlordesmethyldiazepam
- 7-Chloro-1,3-dihydro-5-phenyl-
- Clorazepate (break down)
- 1,3-Dihydro-7-Chloro-5-Phenyl-2H-1
- DESMETHYLDIAZEPAM METHANOL SOLUTION
- Diazepam EP impurity A
- Desmethyldiazepam solution
- 1,3-Dihydro-7-Chloro-5-Phenyl-2H-1,4-Benzodiazepine-2-One
- DESMETHYLDIAZEPAM--DEA SCHEDULE IV ITEM
- NDZ
- 7-chloro-1,3-dihydro-5-phenyl-2h-4-benzodiazepin-2-one
- See more synonyms
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 12 products.
Desmethyldiazepam (Nordazepam), 1mg/ml in Methanol
CAS:Controlled ProductColor and Shape:Single SolutionNordiazepam-d5 (phenyl-d5)
CAS:Controlled ProductPurity:99 atom % DColor and Shape:White SolidMolecular weight:275.757-Chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one (Nordazepam)
CAS:Controlled ProductColor and Shape:NeatNordazepam
CAS:Controlled Product<p>Applications The primary metabolite of Diazepam. A ligand for the GABAA receptor benzodiazepine modulatory site. Anxiolytic.Controlled substance (depressant).<br>References Klotz, U., et al.: Br. J. Clin. Pharmacol., 7, 119 (1979), Konishi, M., et al.: J. Pharm. Sci., 67, 1777 (1978), Andreoli, V., et al.: Arzneim.-Forsch., 27, 436 (1977), Miller, R.P., et al.: Toxicol. Appl. Pharmacol., 25, 453 (1973), Margolis, J., et al.: Drug Metab. Dispos., 31, 606 (2003),<br></p>Formula:C15H11ClN2OColor and Shape:White To Light YellowMolecular weight:270.71Desmethyl diazepam
CAS:Controlled Product<p>Diazepam is a long-acting benzodiazepine drug that is used for the treatment of a variety of conditions, such as anxiety, insomnia, muscle spasms, and alcohol withdrawal. Diazepam has been shown to have anti-convulsant properties. The hydroxyl group on diazepam's side chain is converted to an ester in order to make it more lipid soluble and therefore more readily absorbed by the body. This conversion occurs partially through the action of enzymes found in the liver microsomes of rats and humans. Desmethyldiazepam (DMDZ) is formed from diazepam by the enzyme monoamine oxidase (MAO). DMDZ has similar pharmacological properties to its parent compound but with a shorter duration of action.<br>Maternal blood levels of DMDZ are higher than those found in serum or plasma, which may be due to differences in protein binding between these two compartments.</p>Formula:C15H11ClN2OPurity:Min. 98 Area-%Color and Shape:PowderMolecular weight:270.71 g/molNordazepam (1.0 mg/mL in Methanol)
CAS:Controlled ProductFormula:C15H11ClN2OColor and Shape:Single SolutionMolecular weight:270.71Nordazepam CIV (7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one)
CAS:Controlled ProductAlprazolam(inn), camazepam (inn), chlordiazepoxide (inn), clonazepam (inn), clorazepate & other heterocyclic compounds with nitro atom(s) onlyFormula:C15H11ClN2OColor and Shape:Light Yellow White PowderMolecular weight:270.05599
