CAS 1088-11-5

2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-phenyl-

Description:

2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-phenyl- is a chemical compound belonging to the benzodiazepine class, which is characterized by its fused benzene and diazepine rings. This compound typically exhibits properties such as sedative, anxiolytic, and muscle relaxant effects, making it relevant in pharmacology. The presence of a chlorine atom at the 7-position and a phenyl group at the 5-position contributes to its unique chemical reactivity and biological activity. It is often studied for its potential therapeutic applications, particularly in the treatment of anxiety and sleep disorders. The compound's structure allows for interactions with the central nervous system, primarily through modulation of GABA receptors, which are crucial for inhibitory neurotransmission. Additionally, its solubility and stability can vary based on environmental conditions, influencing its bioavailability and efficacy. Safety and handling precautions are essential due to its pharmacological properties, and it is subject to regulatory controls in many jurisdictions.

Formula:C₁₅H₁₁ClN₂O

InChI:InChI=1/C15H11ClN2O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19)

InChI key:InChIKey=AKPLHCDWDRPJGD-UHFFFAOYSA-N

SMILES:ClC=1C=C2C(=NCC(=O)NC2=CC1)C3=CC=CC=C3

Synonyms:

1-Demethyldiazepam
7-Chloro-1,3-dihydro-1H-5-phenyl-2H-1,4-benzodiazepin-2-one
7-Chloro-1,3-dihydro-5-phenyl-1,4-benzodiazepin-2-one
7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazapin-2-one
7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one
7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-one
7-Chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
7-Chloro-5-phenyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one
7-Chloro-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one
7-Chloro-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one
7-Chloro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
7-Chloro-5-phenyl-2-oxo-1,2-dihydro-1,4-benzodiazepine
7-Chloro-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one
A 101
Calmday
Dealkylprazepam
Demethyldiazepam
Demoxazepam
Desalkylprazepam
Desmethyldiazepam
Dmdz
Madar
N-Demethyldiazepam
N-Deoxydemoxepam
N-Descyclopropylmethylprazepam
N-Desmethyldiazepam
N1-Desmethyldiazepam
N<sup>1</sup>-Desmethyldiazepam
Nordaz
Nordazepam
Nordiazepam
Norprazepam
Nsc 46078
Nsc 631619
Praxadium
Ro 5-2180
Sigma D 7282
Stilny
2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-phenyl-
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-phenyl-
DIAZEPAM, DESMETHYL (RO 5-2180, NORDIAZE P
7-Chloro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
N-Deoxydemoxapam
1,4-BENZODIAZEPIN-2-ONE,7-CHLORO-1,3-DIHYDRO-5-PHENYL-
NDD
Nordiazepam solution
Nordazepam CIV (50 mg) (7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one)
Methanol (test Nordiazepam,1.0mg/mL)
Ro 52180434
Chlordesmethyldiazepam
7-Chloro-1,3-dihydro-5-phenyl-
Clorazepate (break down)
1,3-Dihydro-7-Chloro-5-Phenyl-2H-1
DESMETHYLDIAZEPAM METHANOL SOLUTION
Diazepam EP impurity A
Desmethyldiazepam solution
1,3-Dihydro-7-Chloro-5-Phenyl-2H-1,4-Benzodiazepine-2-One
DESMETHYLDIAZEPAM--DEA SCHEDULE IV ITEM
NDZ
7-chloro-1,3-dihydro-5-phenyl-2h-4-benzodiazepin-2-one
See more synonyms

Found 13 products.

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Nordiazepam-d5 (phenyl-d5)
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 1088-11-5
Purity:99 atom % D
Color and Shape:White Solid
Molecular weight:275.75
Ref: 3U-D7149
50mg
1,880.00€
VAT not included
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Nordazepam (Nordiazepam) 0.1 mg/ml in Methanol
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 1088-11-5
Formula:C₁₅H₁₁ClN₂O
Color and Shape:Colourless
Molecular weight:270.71
Ref: 61-AMP0023.02-02
1ml
80.00€
VAT not included
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Desmethyldiazepam (Nordazepam)
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 1088-11-5
Formula:C₁₅H₁₁ClN₂O
Color and Shape:White To Light Yellow
Molecular weight:270.71
Ref: 61-FOR0023.02
10mg
182.00€
VAT not included
50mg
620.00€
VAT not included
100mg
1,116.00€
VAT not included
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Desmethyldiazepam (Nordazepam), 1mg/ml in Methanol
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 1088-11-5
Formula:C₁₅H₁₁ClN₂O
Color and Shape:Single Solution
Molecular weight:270.71
Ref: LP-DIA-108-1LM
1ml
51.00€
VAT not included
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Desmethyldiazepam (Nordazepam)
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 1088-11-5
Formula:C₁₅H₁₁ClN₂O
Molecular weight:270.71
Ref: LP-DIA-108
10mg
165.00€
VAT not included
50mg
564.00€
VAT not included
100mg
930.00€
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Desmethyldiazepam (Nordazepam)
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 1088-11-5
Color and Shape:Neat
Ref: LP-DIA8
10mg
To inquire
50mg
To inquire
100mg
To inquire
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7-Chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one (Nordazepam)
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 1088-11-5
Formula:C₁₅H₁₁ClN₂O
Color and Shape:Neat
Molecular weight:270.71
Ref: 86-MM0023.02
25mg
516.00€
VAT not included
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Nordazepam (Nordiazepam) 1.0 mg/ml in Methanol
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 1088-11-5
Formula:C₁₅H₁₁ClN₂O
Color and Shape:Colourless
Molecular weight:270.71
Ref: 61-AMP0023.02-01
1ml
92.00€
VAT not included
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Nordazepam
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 1088-11-5
Applications The primary metabolite of Diazepam. A ligand for the GABAA receptor benzodiazepine modulatory site. Anxiolytic.Controlled substance (depressant).
References Klotz, U., et al.: Br. J. Clin. Pharmacol., 7, 119 (1979), Konishi, M., et al.: J. Pharm. Sci., 67, 1777 (1978), Andreoli, V., et al.: Arzneim.-Forsch., 27, 436 (1977), Miller, R.P., et al.: Toxicol. Appl. Pharmacol., 25, 453 (1973), Margolis, J., et al.: Drug Metab. Dispos., 31, 606 (2003),
Formula:C₁₅H₁₁ClN₂O
Color and Shape:Neat
Molecular weight:270.71
Ref: TR-D291595
5mg
106.00€
VAT not included
25mg
289.00€
VAT not included
100mg
850.00€
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Diazepam EP Impurity A
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 1088-11-5
Formula:C₁₅H₁₁ClN₂O
Molecular weight:270.71
Ref: ST-EA-CP-D18001
10mg
799.00€
VAT not included
25mg
1,477.00€
VAT not included
50mg
1,938.00€
VAT not included
100mg
2,289.00€
VAT not included
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Nordazepam (1.0 mg/mL in Methanol)
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 1088-11-5
Formula:C₁₅H₁₁ClN₂O
Color and Shape:Single Solution
Molecular weight:270.71
Ref: TR-KIT0645
5x1ml
112.00€
VAT not included
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Nordazepam
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 1088-11-5
Alprazolam(inn), camazepam (inn), chlordiazepoxide (inn), clonazepam (inn), clorazepate & other heterocyclic compounds with nitro atom(s) only
Formula:C₁₅H₁₁ClN₂O
Color and Shape:Light Yellow White Powder
Molecular weight:270.05599
Ref: 45-1468400
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Desmethyl diazepam
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 1088-11-5
Diazepam is a long-acting benzodiazepine drug that is used for the treatment of a variety of conditions, such as anxiety, insomnia, muscle spasms, and alcohol withdrawal. Diazepam has been shown to have anti-convulsant properties. The hydroxyl group on diazepam's side chain is converted to an ester in order to make it more lipid soluble and therefore more readily absorbed by the body. This conversion occurs partially through the action of enzymes found in the liver microsomes of rats and humans. Desmethyldiazepam (DMDZ) is formed from diazepam by the enzyme monoamine oxidase (MAO). DMDZ has similar pharmacological properties to its parent compound but with a shorter duration of action. Maternal blood levels of DMDZ are higher than those found in serum or plasma, which may be due to differences in protein binding between these two compartments.
Formula:C₁₅H₁₁ClN₂O
Purity:Min. 98 Area-%
Color and Shape:Powder
Molecular weight:270.71 g/mol
Ref: 3D-FD21258
25mg
Discontinued
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Discontinued product