CAS 1092939-17-7

Jakafi

Description:

Jakafi, known generically as ruxolitinib, is a selective inhibitor of Janus kinases (JAK1 and JAK2) and is primarily used in the treatment of certain myeloproliferative neoplasms, such as polycythemia vera and myelofibrosis. It functions by modulating the immune response and reducing inflammation by inhibiting the signaling pathways of various cytokines. Ruxolitinib is administered orally and is characterized by its ability to improve symptoms related to these conditions, such as splenomegaly and constitutional symptoms. The substance has a molecular formula that reflects its complex structure, which includes a pyrrolo[2,3-d]pyrimidine core. Its pharmacokinetics indicate a moderate bioavailability, with metabolism primarily occurring in the liver via cytochrome P450 enzymes. Common side effects may include anemia, thrombocytopenia, and increased risk of infections due to its immunosuppressive properties. Overall, Jakafi represents a significant advancement in targeted therapies for hematological disorders.

Formula: C₁₇H₁₈N₆·H₃PO₄

InChI: InChI=1S/C17H18N6.H3O4P/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16;1-5(2,3)4/h6,8-12,15H,1-5H2,(H,19,20,21);(H3,1,2,3,4)/t15-;/m1./s1

InChI key: InChIKey=JFMWPOCYMYGEDM-XFULWGLBSA-N

SMILES: [C@H](CC#N)(N1C=C(C2=C3C(=NC=N2)NC=C3)C=N1)C4CCCC4.P(=O)(O)(O)O

Synonyms:

• (Betar)-Beta-Cyclopentyl-4-(7H-Pyrrolo(2,3-D)Pyrimidin-4-Yl)-1H-Pyrazole-1-Propanenitrile
• 1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βR)-, phosphate (1:1)
• INC 424 phosphate
• INCB 018424 phosphate
• Incb-018424
• Jakafi
• Jakavi
• R-Incb018424
• R-Ruxolitinib
• Ruxolitinib (INCB 018424)
• Ruxolitinib phosphate
• Ruxolitinib phosphate salt
• INC424
• INCB018424;INCB-018424;INCB 018424
• (betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile phosphate
• Ruxolitinib phosphate(INCB018424)
• Beta-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(Betar)-1H-pyrazole-1-propanenitrile, phosphate
• (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile
• INCB018424 PHOSPHATE;INCB 018424 PHOSPHATE;INCB-018424 PHOSPHATE;RUXOLITINIB
• phosphenoperoxoic acid compound with (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- 1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile and dihydrogen (1:1:1)
• (R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosph
• Ruxolitinib (INCB-18424) phosphate
• Ruxolitinib Phosphate (INC-424, INCB-18424, INCB-018424, Jakafi and Jakavi)
• (R)-3-(4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate
• INCB018424 (phosphate)
• Ruxolitinib phosphate ISO 9001：2015 REACH
• (3R)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile phosphate
• Jakafi (ruxolitinib)
• INCB 018424(Ruxolitinib Phosphate)
• RUXOLITINIB(INCB018424) PHOSPHATE
• Ruxotinib phosphate
• 10-dimethoxyptercarpan
• (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile phosphoric acid
• Ruxolitinib phosphate, >=98%
• (βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazole-1-propanenitrile Phosphate

Ruxolitinib phosphate

CAS: 1092939-17-7

Ruxolitinib phosphate

Purity: ≥98%

Molecular weight: 404.36g/mol

Ref: 54-BUP17785

Ruxolitinib Phosphate

CAS: 1092939-17-7

Formula: C₁₇H₁₈N₆·H₃O₄P

Color and Shape: White To Off-White Solid

Molecular weight: 306.37 97.99

Ref: 4Z-R-093001

(R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate

CAS: 1092939-17-7

(R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate

Purity: 98%

Molecular weight: 404.36g/mol

Ref: 54-OR302722

Ruxolitinib Phosphate Salt

CAS: 1092939-17-7

Ruxolitinib Phosphate Salt

Formula: C₁₇H₁₈N₆·H₃O₄P

Purity: >99%

Color and Shape: white solid

Molecular weight: 404.36g/mol

Ref: 54-BIFK0028

Ruxolitinib phosphate

CAS: 1092939-17-7

Ruxolitinib phosphate (INCB18424 phosphate) is a JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM. Cost-effective and quality-assured.

Formula: C₁₇H₂₁N₆O₄P

Purity: 98% - >99.99%

Color and Shape: Solid

Molecular weight: 404.36

Ref: TM-T3043

Ruxolitinib . phosphate salt

CAS: 1092939-17-7

Ref: 7W-GW4048

Ruxolitinib Phosphate

Controlled Product

CAS: 1092939-17-7

Applications The phosphate salt of Ruxolitinib (R702000). Ruxolitinib is a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor used in the treatment of myeloproliferative neoplasms and psoriasis.
References Shilling, A.D. et al.: Drug Metab. Disp., 38, 2023 (2010); Mesa, R.A.: IDrugs, 13, 394 (2010); Campas-Moya, C.: Drugs Fut., 35, 457 (2010);

Formula: C₁₇H₁₈N₆·H₃O₄P

Color and Shape: Off White Solid

Molecular weight: 404.36

Ref: TR-R702005

Ruxolitinib phosphate

CAS: 1092939-17-7

Purity: 99%

Molecular weight: 404.367

Ref: 10-F979379

Ruxolitinib phosphate

Controlled Product

CAS: 1092939-17-7

Ruxolitinib is a janus tyrosine kinase inhibitor active specifically on sub-types JAK1 and JAK2 with IC50 values in the nanomolar range. JAK1 and JAK2 are kinases involved in the regulation of hematopoiesis. Clinically applied to the treatment of intermediate and high-risk myelofibrosis, ruxolitinib is usually well tolerated by patients.

Formula: C₁₇H₁₈N₆•H₃O₄P

Purity: Min. 95%

Molecular weight: 404.36 g/mol

Ref: 3D-FR167906