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Jakafi

CAS 1092939-17-7: Jakafi

Description:Jakafi, known generically as ruxolitinib, is a selective inhibitor of Janus kinases (JAK1 and JAK2) and is primarily used in the treatment of certain myeloproliferative neoplasms, such as polycythemia vera and myelofibrosis. It functions by modulating the immune response and reducing inflammation by inhibiting the signaling pathways of various cytokines. Ruxolitinib is administered orally and is characterized by its ability to improve symptoms related to these conditions, such as splenomegaly and constitutional symptoms. The substance has a molecular formula that reflects its complex structure, which includes a pyrrolo[2,3-d]pyrimidine core. Its pharmacokinetics indicate a moderate bioavailability, with metabolism primarily occurring in the liver via cytochrome P450 enzymes. Common side effects may include anemia, thrombocytopenia, and increased risk of infections due to its immunosuppressive properties. Overall, Jakafi represents a significant advancement in targeted therapies for hematological disorders.

Formula:C17H18N6·H3O4P

InChI:InChI=1S/C17H18N6.H3O4P/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16;1-5(2,3)4/h6,8-12,15H,1-5H2,(H,19,20,21);(H3,1,2,3,4)/t15-;/m1./s1

InChI key:InChIKey=JFMWPOCYMYGEDM-XFULWGLBSA-N

SMILES:N#CCC(N1N=CC(=C1)C=2N=CN=C3NC=CC32)C4CCCC4.O=P(O)(O)O

  • Synonyms:
  • (Betar)-Beta-Cyclopentyl-4-(7H-Pyrrolo(2,3-D)Pyrimidin-4-Yl)-1H-Pyrazole-1-Propanenitrile
  • 1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βR)-, phosphate (1:1)
  • INC 424 phosphate
  • INCB 018424 phosphate
  • Incb-018424
  • Jakafi
  • Jakavi
  • R-Incb018424
  • R-Ruxolitinib
  • Ruxolitinib (INCB 018424)
  • See more synonyms
  • Ruxolitinib phosphate
  • Ruxolitinib phosphate salt
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Found 7 products.

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Ref: 54-OR302722

1g421.00 €
5g1,307.00 €
100mg127.00 €
250mg179.00 €
Estimated delivery in United States, on Wednesday 5 Mar 2025
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Ruxolitinib Phosphate

CAS:1092939-17-7

Ref: 4Z-R-093001

5mgTo inquire
10mgTo inquire
25mgTo inquire
50mgTo inquire
100mgTo inquire
Estimated delivery in United States, on Wednesday 5 Mar 2025
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Ruxolitinib phosphate

CAS:1092939-17-7

Ref: TM-T3043

1g615.00 €
5mg52.00 €
10mg65.00 €
25mg82.00 €
50mg97.00 €
100mg145.00 €
200mg227.00 €
500mg418.00 €
1mL*10mM (DMSO)59.00 €
Estimated delivery in United States, on Tuesday 11 Mar 2025
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Ref: 7W-GW4048

5mg115.00 €
25mg194.00 €
100mg396.00 €
Estimated delivery in United States, on Tuesday 11 Mar 2025
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Ruxolitinib Phosphate Salt

CAS:1092939-17-7

Ref: 54-BIFK0028

10mg84.00 €
25mg125.00 €
50mg193.00 €
Estimated delivery in United States, on Tuesday 11 Mar 2025
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Ruxolitinib Phosphate

Controlled Product
CAS:1092939-17-7

Ref: TR-R702005

10mg156.00 €
100mg940.00 €
250mg1,654.00 €
Estimated delivery in United States, on Friday 14 Mar 2025
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Ruxolitinib phosphate

Controlled Product
CAS:1092939-17-7

Ref: 3D-FR167906

1g393.00 €
5g799.00 €
10g1,064.00 €
250mg186.00 €
500mg268.00 €
Estimated delivery in United States, on Tuesday 29 Apr 2025
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