CAS 1094048-77-7

I-OMe-Tyrphostin AG 538

CAS: 1094048-77-7

I-OMe-Tyrphostin AG 538

Formula: C₁₇H₁₂INO₅

Purity: ≥95%

Molecular weight: 437.19

Ref: 54-BUP09174

TYRPHOSTIN I-OME-AG 538

CAS: 1094048-77-7

2-(3,4-Dihydroxybenzoyl)-3-(4-hydroxy-3-iodo-5-methoxyphenyl)prop-2-enenitrile is a high purity ion channel inhibitor with IC50 of 1.8 nM. It has been shown to inhibit the activity of voltage gated sodium channels in rat hippocampal neurons and human erythrocytes. The binding affinity of 2-(3,4-dihydroxybenzoyl)-3-(4-hydroxy-3-iodo-5 methoxyphenyl)prop-2 enenitrile for the nicotinic acetylcholine receptor (nAChR), as determined by competitive radioligand binding assay, is 21 pM. This compound also inhibits the activity of potassium channels and has been shown to bind to peptides and antibodies.

Formula: C₁₇H₁₂INO₅

Purity: Min. 95%

Molecular weight: 437.18 g/mol

Ref: 3D-UTB04877

I-OMe-Tyrphostin AG 538

CAS: 1094048-77-7

I-OMe-Tyrphostin AG 538: IGF-1R & PI5P4Kα inhibitor, ATP-competitive, IC50 of 1 µM, targets IGF-1R pathway, cytotoxic in nutrient-poor PANC1 cells.

Formula: C₁₇H₁₂INO₅

Purity: 98.8%

Color and Shape: Solid

Molecular weight: 437.19

Ref: TM-T11593