CAS 109838-85-9

(R)-2,5-dihydro-3,6-dimethoxy-2-iso-propylpyrazine

Formula: C₉H₁₆N₂O₂

InChI: InChI=1/C9H16N2O2/c1-6(2)8-9(13-4)10-5-7(11-8)12-3/h6,8H,5H2,1-4H3/t8-/m1/s1

InChI key: FCFWEOGTZZPCTO-MRVPVSSYSA-N

SMILES: CC(C)[C@@H]1C(=NCC(=N1)OC)OC

Synonyms:

• (R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine
• (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine
• (2R)-3,6-dimethoxy-2-(propan-2-yl)-2,5-dihydropyrazine
• (2R)-2,5-Dihydro-2-isopropyl-3,6-dimethoxypyrazine
• 2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine
• (2R)-(-)-2,5-DIHYDRO-3,6-DIMETHOXY-2-ISOPROPYLPYRAZINE
• (2R)-2,5-Dihydro-3,6-dimethoxy-2-(1-methylethyl)pyrazine
• BISLACTIMETHER
• (2R)-(-)-2,5-DIHYDRO-3,6-DIMETHOXY-2-ISOPROPYLPYRAZINE, 98+%
• (2R)-3,6-DIMETHOXY-2-(1-METHYLETHYL)-2,5-DIHYDROPYRAZINE
• (R)-2,5-DIMETHOXY-3-ISOPROPYL-3,6-DIHYDROPYRAZINE
• zR{-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine
• SCHOELLKOPF-HARTWIG-REAGENT
• (2R)-(-)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine (aka (R )-Schollkopf reagent)
• (R)-2,5-DIHYDRO-3,6-DIMETHOXY-2-ISOPROPYLPIPERAZINE
• (-)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine
• (R)-Schollkopf Reagent
• Pyrazine, 2,5-dihydro-3,6-dimethoxy-2-(1-methylethyl)-, (2R)-(9CI)

(R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

CAS: 109838-85-9

Formula: C₉H₁₆N₂O₂

Purity: >95.0%(GC)

Color and Shape: Colorless to Yellow clear liquid

Molecular weight: 184.24

Ref: 3B-D3256

(R)-3-Isopropyl-2,5-dimethoxy-3,6-dihydropyrazine, 98%

CAS: 109838-85-9

(R)-3-Isopropyl-2,5-dimethoxy-3,6-dihydropyrazineChiral auxiliary for the synthesis of -amino acids. It is an inhibitor with antitumor activity. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer

Formula: C₉H₁₆N₂O₂

Purity: 98%

Color and Shape: Colorless to yellow to orang, Liquid

Molecular weight: 184.24

Ref: 02-H56077

(R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine

CAS: 109838-85-9

Formula: C₉H₁₆N₂O₂

Purity: 97%

Color and Shape: Liquid

Molecular weight: 184.2355

Ref: IN-DA0032ER

(R)-3-Isopropyl-2,5-dimethoxy-3,6-dihydropyrazine

CAS: 109838-85-9

(R)-3-Isopropyl-2,5-dimethoxy-3,6-dihydropyrazine

Formula: C₉H₁₆N₂O₂

Purity: >99%

Color and Shape: Liquid

Molecular weight: 184.23553

Ref: 54-OR925455

(R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine (>85% Purity)

Controlled Product

CAS: 109838-85-9

Stability Moisture Sensitive
Applications An inhibitor with antitumor activity.
References Plumb, J., et al.: Mol. Cancer Ther., 2, 721 (2003), de Ruijter, A., et al.: Biochem. J., 370, 737 (2003), Dey, P., et al.: Curr. Med. Chem., 13, 2909 (2006), Maiso, P., et al.: Cancer Res., 66, 5781 (2006), Paris, M., et al.: J. Med. Chem., 51, 1505 (2008),

Formula: C₉H₁₆N₂O₂

Purity: >85%

Color and Shape: Neat

Molecular weight: 184.24

Ref: TR-I824430

(R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine

CAS: 109838-85-9

(R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine and its enantiomer (S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine are also known as Schöllkopf chiral auxiliaries or Schöllkopf reagents, and are used to produce optically pure α-amino acids via asymmetric synthesis. The Schöllkopf reagent can be deprotonated at the prochiral α-carbon, and the resulting enolate is trapped with electrophiles to yield adducts with high (typically > 95% d.e.) diastereoselectivity. The enolate is essentially planar, and the steric bulk of the isopropyl group directs the incoming electrophile to attack from the opposite face, yielding trans adducts. A wide range of electrophiles including alkyl halides, alkyl sulfonates, acyl chlorides, aldehydes, ketones, epoxides, thioketones and enones can be used. Hydrolysis, typically under mild acidic conditions, yields the non-substituted amino acid with high (typically > 95 e.e.) enantiopurity.

Formula: C₉H₁₆N₂O₂

Purity: Min. 98%

Color and Shape: Colorless Yellow Clear Liquid

Molecular weight: 184.24 g/mol

Ref: 3D-FD04039

(R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

CAS: 109838-85-9

Purity: 96%

Color and Shape: Liquid

Molecular weight: 184.24

Ref: 10-F790908

(R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

CAS: 109838-85-9

(R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

Formula: C₉H₁₆N₂O₂

Purity: 97%

Molecular weight: 184.24

Ref: IN-DG47372