CAS 11006-33-0

phleomycin from streptomyces verticillus

Description:

Phleomycin is an antitumor antibiotic derived from the bacterium Streptomyces verticillus. It is characterized by its ability to induce DNA strand breaks, which contributes to its efficacy in cancer treatment. Phleomycin is a glycopeptide, consisting of a complex structure that includes a peptide backbone and a sugar moiety, which enhances its solubility and biological activity. The compound exhibits a broad spectrum of activity against various types of tumors, particularly germ cell tumors and lymphomas. Its mechanism of action involves binding to DNA and generating free radicals, leading to oxidative damage. Phleomycin is typically administered via injection and is known for its potential side effects, including pulmonary toxicity and skin reactions. Due to its unique properties, it is often used in combination with other chemotherapeutic agents to enhance therapeutic outcomes. The CAS number 11006-33-0 uniquely identifies phleomycin in chemical databases, facilitating research and clinical applications.

Formula: C₅₅H₈₆N₂₀O₂₁S₂

InChI: InChI=1/C51H75N17O21S2/c1-16-29(65-41(68-38(16)54)21(8-27(53)72)60-9-20(52)39(55)78)44(82)67-31(34(22-10-58-15-61-22)88-49-50(5,36(76)33(74)25(11-69)87-49)89-47-37(77)51(85,48(57)84)35(75)26(12-70)86-47)45(83)62-18(3)32(73)17(2)42(80)66-30(19(4)71)43(81)59-7-6-28-63-24(14-90-28)46-64-23(13-91-46)40(56)79/h10,13,15,17-18,20-21,24-26,30-37,47,49,60,69-70,73-77,85H,6-9,11-12,14,52H2,1-5H3,(H2,53,72)(H2,55,78)(H2,56,79)(H2,57,84)(H,58,61)(H,59,81)(H,62,83)(H,66,80)(H,67,82)(H2,54,65,68)/t17?,18?,20?,21?,24?,25-,26?,30?,31?,32?,33+,34?,35-,36-,37-,47-,49-,50-,51+/m0/s1

InChI key: QRBLKGHRWFGINE-UGWAGOLRSA-N

SMILES: CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)O[C@H]3[C@@]([C@H]([C@@H]([C@@H](O3)CO)O)O)(C)O[C@H]4[C@@H]([C@]([C@H](C(O4)CO)O)(C(=O)N)O)O)C(=O)NC(C)C(C(C)C(=O)NC(C(=O)C)C(=O)NCCC5=NC(CS5)C6=NC(=CS6)C(=O)N)O

Synonyms:

• 2'-{5-acetyl-15-(6-amino-2-{3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl}-5-methylpyrimidin-4-yl)-13-[{[(2R,3S,4S,5S,6S)-3-{[(2S,3R,4R,5S)-4-carbamoyl-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)-3-methyltetrahydro-2H-pyran-2-yl]oxy}(1H-imidazol-5-yl)methyl]-9-hydroxy-8,10-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazapentadec-1-yl}-4',5'-dihydro-2,4'-bi-1,3-thiazole-4-carboxamide (non-preferred name)
• Phleomycin
• Phleomycin Streptomyces verticillus
• phleomycin from streptomyces*verticillus
• PHLEOMYCIN USP/EP/BP
• phleomycincomplex
• ZEOCIN(TM)
• CL990-cin
• PHLEOMYCIN FROM STREPOMYCES VERTICILLUS,
• nsc616586
• hleoMycin froM streptoMyces verticillus

Phleomycin, 20 mg/ml in 5mM HEPES buffer, sterile-filtered

CAS: 11006-33-0

Phleomycin, 20mg/mL in 5mM HEPES buffer, sterile-filtered

Ref: 02-J67027

Phleomycin

CAS: 11006-33-0

Phleomycin is one of the anticancer glycopeptide antibiotics which cause DNA cleavage.

Formula: C₄₈H₆₉N₁₇O₂₀S₂

Purity: 98%

Color and Shape: Blue Solid

Molecular weight: 1268.29

Ref: TM-T21498

Phleomycin

CAS: 11006-33-0

Phleomycin

Formula: C₅₅H₈₄N₂₀O₂₁S₂

Color and Shape: Solid-Powder

Molecular weight: 1425.50685

Ref: 54-BI3852

Phleomycin

CAS: 11006-33-0

Formula: C₅₅H₈₅ClCuN₂₀O₂₁S₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 1525.5138

Ref: IN-DA00HBO1

Phleomycin, 1 pack = 1 vial

CAS: 11006-33-0

Phleomycin, 1 pack = 1 vial

Formula: C₅₅H₈₄N₂₀O₂₁S₂

Molecular weight: 1425.53

Ref: 54-BI3852A

Phleomycin

CAS: 11006-33-0

Formula: C₅₅H₈₅O₂₁N₂₀S₂Cu·HCl

Purity: ≥ 90% (HPLC)

Color and Shape: Blue, hygroscopic powder

Molecular weight: 1525

Ref: 7W-GA6020

Phleomycin (PLM) ex. Streptomyces verticillus for cell culture, Endotoxin (BET) 1.0EU/mg

CAS: 11006-33-0

Formula: C₅₁H₇₅N₁₇O₂₁S₂

Purity: 80-120%

Color and Shape: Blue, Powder

Molecular weight: 1326.37

Ref: SR-62374

Phleomycin HCl

CAS: 11006-33-0

Phleomycin HCl is an antibiotic compound derived from *Streptomyces verticillus*, which is known for its robust DNA-cleaving activity. As an antibiotic, it functions primarily by inducing breaks in DNA strands, thereby inhibiting DNA replication and transcription processes. This mechanism of action is particularly effective in targeting rapidly dividing cells, making Phleomycin a valuable tool in molecular biology.

Formula: C₅₅H₈₅O₂₁N₂₀S₂Cu•HCl

Color and Shape: Blue Powder

Molecular weight: 1,525 g/mol

Ref: 3D-AP156948

Phleomycin

CAS: 11006-33-0

Phleomycin is an antibiotic, which is derived from the bacterium *Streptomyces verticillus*. Its mode of action involves binding to DNA and inducing breaks by generating free radicals in the presence of oxygen and ferrous ions, leading to cell death. Phleomycin is prominently used in molecular biology applications as a selective agent in the generation of stable transfectants. It is particularly effective in selecting for cells that have integrated vectors conferring resistance, such as the Sh ble gene used in yeast, plant, and mammalian cell systems. Due to its potent DNA-cleaving ability, Phleomycin is valuable in studies requiring stringent selection pressure. Researchers commonly utilize it in experiments focusing on genetic modification and cellular resistance development.

Formula: C₅₁H₇₅N₁₇O₂₁S₂

Purity: Min. 95%

Molecular weight: 1,326.38 g/mol

Ref: 3D-AP106412