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CAS 110764-78-8

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Cytidine, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

Description:
Cytidine, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] is a complex nucleoside derivative primarily used in the field of molecular biology and biochemistry, particularly in the synthesis of oligonucleotides. This compound features a cytidine base, which is a nucleoside composed of a pyrimidine base (cytosine) and a ribose sugar, modified with various functional groups that enhance its stability and reactivity. The presence of the N-benzoyl group and the bis(4-methoxyphenyl)phenylmethyl moiety contributes to its lipophilicity and solubility in organic solvents, making it suitable for various synthetic applications. The 2′-O-methyl modification provides resistance to enzymatic degradation, while the phosphoramidite group allows for efficient coupling during oligonucleotide synthesis. Overall, this compound is characterized by its structural complexity, functional versatility, and utility in the development of nucleic acid-based technologies.
Formula:C47H54N5O9P
InChI:InChI=1S/C47H54N5O9P/c1-32(2)52(33(3)4)62(59-30-14-28-48)61-42-40(60-45(43(42)57-7)51-29-27-41(50-46(51)54)49-44(53)34-15-10-8-11-16-34)31-58-47(35-17-12-9-13-18-35,36-19-23-38(55-5)24-20-36)37-21-25-39(56-6)26-22-37/h8-13,15-27,29,32-33,40,42-43,45H,14,30-31H2,1-7H3,(H,49,50,53,54)/t40-,42-,43-,45-,62?/m1/s1
InChI key:InChIKey=JFFSFQRVIPPCBC-VKBHKTMGSA-N
SMILES:C(OC[C@@H]1[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](OC)[C@@H](O1)N2C(=O)N=C(NC(=O)C3=CC=CC=C3)C=C2)(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6
Synonyms:
  • 2'-OMe-Bz-C Phosphoramidite
  • Cytidine, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • Cytidine, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
  • N-Blocked-5'-O-Dmt-2'-O-Me Ced Cytosine Phosphoramidite
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